The article defines the dominant criteria for the functional symbiosis of macro-regional and local-regional systems with a large number of producers of tourism products. A macroeconomic model was developed for calculating the integrated index of international cooperation of the country in the European geoeconomic space of the tourism industry based on standardized variable indicators. A detailed analysis of the development of the tourism industry in Ukraine was carried out, with the determination of the scope of tourist flows in the pre-war period and during the war period. The forecast dynamics of the development of the potential of international cooperation of Ukraine in the geo-economic space of macro-regional systems of Europe are provided.