Aims and Objectives: The practice of self-medication may lead to lack of clinical evaluation by a trained medical professional and delay in effective therapy. This study was aimed to find the prevalence of self-medication and identify the common causes of illness/symptoms that necessitate self-medication awareness and develop perception regarding methods to prevent the growing trend of self-medication and associated factors among population those who visit a community outreach programme in Madurai, India. Material and Methods: A cross-sectional, questionnaire-based survey in which a semi-structured questionnaire was used to collect data. A total of 238 participants were included in the study with respect to the final sample size. Data were analysed using SPSS software with a significance level of 0.05, and statistical relationship between the variables was analysed using chi-square test. Results: The prevalence of self-medication is 69.32 per cent. Headache (59.6%), fever (60%), cough (51%) and toothache (25%) were the most common symptoms for self-medication. The most commonly used drugs/substances were analgesics (65.54%), warm saline (38.23%) and hot drinks (27.73%). The most common reason for resorting to self-medication practice was previous experience of successfully treating a similar illness. The majority of the participants (56.97%) were in their third-fourth decade of life. The association of self-medication with characteristics such as male gender, urban locality, and upper-and lower-middle class was statistically significant at a p-value of 0.005. Conclusion: Self-medication practices were quite high in this study, and these practices were also prevalent among the educated people. The physicians and health professionals have to spend some extra time in educating patients regarding the same. Improved knowledge and understanding about self-medication may result in rationale use and thus limit emerging microbial antibiotic resistance issues.