How the availability of information affects the responsibility of the researcher?As a forum for the publication of high-quality original research in Physiology and related disciplines, Acta Physiologica is, by its very nature, dedicated to the responsible advancement of scientific progress-and its communication. However, search terms such as "responsible research" entered into the journal homepage search field will retrieve 0 results. For a quick coffee break, let us sit back and consider for a moment concepts of scientific progress, its drivers, pitfalls and mechanisms of motivation and control.How are we, as authors, publishers and readers, implementing concepts of high-quality, responsible research and the dissemination of its results into our everyday actions?Epistemology distinguishes science "from other domains of human culture by its progressive nature". 1 Research theorists are working on the main questions defining scientific progress, or rather, scientific change; watching, dissecting and analyzing how it happens, in a strikingly similar manner to how other disciplines, such as the life sciences, investigate their subject matters. Does knowledge grow, for example, in spurts and stalls, or is it a continuous, cumulative process?Nisbet 2 famously argued that the latter view characterizes the Modern Age: Knowledge is driven by a gradual accumulation of data, facts or information, to which consecutive generations of researchers contribute. The famous philosophers of Enlightenment trusted the process to move mankind ever further toward discovering, ultimately, the truth. Thomas Kuhn, in the 1960s, coined the term "paradigm shifts," when he contradicted this view: periodic revolutions, in his opinion, characterized scientific progress, while truth is not objective, but a consensus, based on what is known at a given point in time. 3 Stop here for a second and imagine how simple yet important it is to communicate this: While knowledge gained in a responsible, reproducible process underlies all evidencebased decision-making, there is never "the truth" to be found, only consensus, which changes, and even more rapidly so whenever a lot of resources and efforts are invested, as was the case during the 2020/21 pandemic.