Percentage of positive biopsy cores, preoperative prostate‐specific antigen (PSA) level, pT and Gleason score as predictors of PSA recurrence after radical prostatectomy: a multi‐institutional outcome study in Japan

Yokomizo, Akira; Murai, Masaru; Baba, Shirō; Ogawa, Osamu; Tsukamoto, Taiji; Niwakawa, Masashi; Tobisu, Ken Ichi; Kinukawa, Naoko; Naito, Seiji

doi:10.1111/j.1464-410x.2006.06379.x

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…When measured in the RP specimen, the expression of VEGF‐A could help to identify patients at high risk of tumour recurrence. Currently the main postoperative factors that predict the risk of recurrence are the Gleason score, the pathological stage, and the surgical margin status [11,12]. VEGF‐A expression in the RP specimen could be an additional factor for predicting outcome; it could be considered before indicating an adjuvant treatment.…”

Section: Discussionmentioning

confidence: 99%

The expression of vascular endothelial growth factor is associated with the risk of cancer progression after radical prostatectomy

Peyromaure¹,

Camparo

Badoual³

et al. 2007

BJU International

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OBJECTIVE To analyse the prognostic value of vascular endothelial growth factor (VEGF) in men with clinically localized prostate cancer. PATIENTS AND METHODS Paraffin wax‐embedded sections from the radical prostatectomy (RP) specimens of 40 men operated for clinically localized prostate cancer were used to build tissue microarrays. Of these patients, 17 had cancer progression and bone metastases after RP (group 1), and 23 remained free‐of‐tumour recurrence after RP (group 2). VEGF‐A expression was examined in the RP specimens using immunohistochemistry. RESULTS The groups had similar tumour characteristics in terms of prostate‐specific antigen level, Gleason score, and pathological stage. VEGF‐A expression was significantly higher in group 1 than in group 2 (P = 0.046). In logistic regression analysis, VEGF‐A expression was the most significant predictive factor of cancer progression after RP. CONCLUSION VEGF‐A expression in prostate cancer tissue is associated with the risk of cancer progression after RP. These results suggest that VEGF‐A expression has a prognostic impact in clinically localized prostate cancer.

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Section: Discussionmentioning

confidence: 99%

The expression of vascular endothelial growth factor is associated with the risk of cancer progression after radical prostatectomy

Peyromaure¹,

Camparo

Badoual³

et al. 2007

BJU International

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“…The 5-year progression-free, and biochemical relapse-free survival rates according to the risk group were 100%, 90.8% in the low-risk group, 98.3%, 75.7% in the intermediate-risk group and 93.6%, 67.6% in the high-risk group. 100 The author also mentioned that the survival result is comparable to T1-T2 patients who had a radical prostatectomy in Japan, 101 indicating that EBRT is a promising option in low and intermediate risk patients in Asia. However, consensus has not been reached on the practice and management of postoperative RT for patients with Prostate cancer in Japan yet.…”

Section: Treatmentmentioning

confidence: 99%

Prostate cancer in East Asia: evolving trend over the last decade

Zhu

Wang

et al. 2015

Asian J Androl

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Prostate cancer is now becoming an emerging health priority in East Asia. Most of our current knowledge on Prostate cancer has been generated from studies conducted in Western population; however, there is considerable heterogeneity of Prostate cancer between East and West. In this article, we reviewed epidemiologic trends, risk factors, disease characteristics and management of Prostate cancer in East Asian population over the last decade. Growing evidence from East Asia suggests an important role of genetic and environmental risk factors interactions in the carcinogenesis of Prostate cancer. Exposure to westernized diet and life style and improvement in health care in combination contribute substantially to the increasing epidemic in this region. Diagnostic and treatment guidelines in East Asia are largely based on Western knowledge. Although there is a remarkable improvement in the outcome over the last decade, ample evidence suggests an inneglectable difference in diagnostic accuracy, treatment efficacy and adverse events between different populations. The knowledge from western countries should be calibrated in the Asian setting to provide a better race-based treatment approach. In this review, we intend to reveal the evolving trend of Prostate cancer in the last decade, in order to gain evidence to improve Prostate cancer prevention and control in East Asia.

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“…These results suggest that the detection of prostate cancer at a repeat biopsy does not predict a favorable outcome. Rather, several studies have indicated that the number or percentage of positive biopsy cores may be an important predictor of a favorable outcome [ 4 - 7 ].…”

Section: Introductionmentioning

confidence: 99%