Background:The reference point cumulative air kerma (K a,r ) is a commonly used dose quantity for establishing substantial radiation dose levels (SRDLs) that can provide guidance for patient dose management actions following fluoroscopically guided procedures. However, the K a,r may not correlate well with the patient peak skin dose (D skin,max ) because the relationship between K a,r and D skin,max may vary widely due to clinical variations. Therefore, it may be prudent for institutions to establish different K a,r -based SRDL values based on the clinical procedure type. Purpose: The present study investigates the relationship between K a,r and D skin,max for different clinical services and how that variation may overestimate or underestimate the need for patient follow-up. Additionally, the study suggests a possible framework for establishing K a,r SRDLs based on the clinical data analysis. Methods: A retrospective analysis was performed for fluoroscopically guided interventions exceeding 5 Gy K a,r . For each procedure, the patient D skin,max was estimated and the ratio of D skin,max to K a,r (DKR) was calculated. Results were pooled into one of three clinical service categories: body interventions (n = 33), cardiac interventions (n = 81), or neurological (neuro) interventions (n = 44). The distributions in K a,r , D skin,max , and DKR were analyzed in aggregate and by the clinical service category. Results: The median K a,r values for procedures exceeding 5 Gy were 6.0 Gy (95% CI [5.6, 6.4]) for body interventions, 5.8 Gy (95% CI [5.5, 6.0]) for cardiac interventions, and 6.3 Gy (95% CI [5.9, 6.6]) for neuro interventions. D skin,max for the same procedure data sets were 5.0 Gy (95% CI [4.4, 5.6]) for body interventions, 5.5 Gy (95% CI [5.2, 5.8]) for cardiac interventions, and 3.7 Gy (95% CI [3.4, 4.0]) for neuro interventions. This resulted in median DKR values of 0.81 for body interventions, 0.91 for cardiac interventions, and 0.59 for neuro interventions.Conclusions: This study illustrates the need to understand the relationship between the reported K a,r and the patient D skin,max for different types of interventional procedures. This is especially important when an institution uses K a,r as the parameter for establishing an SRDL threshold to identify patients who may require clinical follow-up. The implications of this research and a guide for how to implement these findings are elaborated on in the Discussion.