Percent body fat, fractures and risk of osteoporosis in women

Wyshak, Grace

doi:10.1007/s12603-010-0110-1

“…It is well-known that lipid metabolism has a close relationship with bone metabolism. The body fat percentage is positively associated with osteoporotic fracture, which leads to the emerging of an effective alternative tool for screening and assessing risk of osteoporosis by estimating body fat percentage from age, height, and weight (Wyshak, 2010 ). Biochemical analysis showed that higher level of lipids in blood is accompanied with the osteoporotic postmenopausal women (Li et al, 2015 ), while lipid-lowering drug, such as statin, could increase bone mineral density in patients and in rodents (Parhami et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats

Xi

¹

,

Sham

²

,

Chan

³

et al. 2018

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The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metabolites and the associated metabolic pathways that contribute to the beneficial effects of SWR on bone in vivo. Aged female Sprague Dawley rats (9 months old) were either sham-operated or ovariectomized for 12 weeks, before receiving treatment for another 12 weeks with the following treatment groups (n = 12 each): vehicle (Sham), vehicle (OVX), Premarin (130 μg/kg) or low (57 mg/kg), medium (114 mg/kg), and high (228 mg/kg) doses of SWR. The results showed that SWRH significantly suppressed bone loss, improved bone micro-architecture and increased bone strength on tibia without stimulating uterus weight gain in OVX rats. Premarin exerted similar bone protective effects as SWRH but elicited uterotrophic effects in OVX rats. The metabolic profiles of serum samples were analyzed by using ultra-performance liquid chromatography quadrupole time-of flight mass spectrometry and gas chromatography time-of flight mass spectrometry, and the metabolites that were significantly altered were identified by multivariate statistical analysis. Our study indicated that SWRH effectively restored the changes of 26 metabolites induced by estrogen-deficiency in OVX rats, which related to lipids, amino acids, tryptophan metabolisms, and anti-oxidative system. A subsequent validation showed that the serum level of superoxide dismutase and catalase were indeed up-regulated, while the serotonin level in a tryptophan hydroxylase 1 (TPH1) high expressing cells (rats RBL-2H3 cells) was down regulated after treatment with SWR. The results also suggested that the gut-microbiota may play an important role on the bone protective effects of SWR. The current study provides insight for understanding the unique mechanism of actions of SWR that might be involved in achieving bone protective effects in vivo.

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“…However they have a limitation of their use in spine. DEXA and bone densitometer enable early diagnosis of this disorder [3][4][5][6] . Recent studies on osteoporosis traced out the related factors for loss of Bone mineral density.…”

Section: Introductionmentioning

confidence: 99%

Correlation of anthropometric measurements with bone mineral density in south Indian population

Annamalai¹,

Lal²

2018

Int. J. Orthop. Sci.

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There is no data or very limited data available about the relation between anthropometric measurements like weight and height, and bone mineral density based on sex and age of South Indian population. Identifying persons at risk of sustaining osteoporotic fractures is crucial for the prevention of fracture. Therefore the present was undertaken for the identification, prevention and timely treatment of osteoporosis. The study population consisted of 350 patients (both male and female patients). The study was conducted during the period of January 2016 to November 2017. Patients with risk factors for osteoporosis as per WHO criteria were included for the study. Patients with Osteomyelitis, fracture, tumor pathology or trauma in bone were excluded from the study. Out of 350 patients, 110 were male subjects (31.5%) and 240 females (72.2%). Correlation analysis was used to investigate the continuous variables related with bone mineral density (BMD). Data were analyzed by means of SPSS version 16.0 using t-test and one way ANOVA. There is high prevalence of osteoporosis among men and women of this population. It can be concluded that certain anthropometric parameters (BMI and weight) can considerably affect one's risk of developing osteoporosis. Therefore, weight and BMI can be used as to screen those at risk of developing osteoporosis and its related complication.

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“…In osteoporosis, bone is normal but reduced in density (bone mass per unit volume of bone tissue). DEXA (Dual Energy X-ray absorptiometry) is the gold standard in quantitatively estimating bone mineral density [3][4][5] . Ultrasonic densitometers do not have a risk of radiation, are portable and there are reports to show that the sensitivity is similar to DEXA.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

Int. J. Orthop. Sci.

0

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There is no data or very limited data available about the relation between anthropometric measurements like weight and height, and bone mineral density based on sex and age of South Indian population. Identifying persons at risk of sustaining osteoporotic fractures is crucial for the prevention of fracture. Therefore the present was undertaken for the identification, prevention and timely treatment of osteoporosis. The study population consisted of 350 patients (both male and female patients). The study was conducted during the period of January 2016 to November 2017. Patients with risk factors for osteoporosis as per WHO criteria were included for the study. Patients with Osteomyelitis, fracture, tumor pathology or trauma in bone were excluded from the study. Out of 350 patients, 110 were male subjects (31.5%) and 240 females (72.2%). Correlation analysis was used to investigate the continuous variables related with bone mineral density (BMD). Data were analyzed by means of SPSS version 16.0 using t-test and one way ANOVA. There is high prevalence of osteoporosis among men and women of this population. It can be concluded that certain anthropometric parameters (BMI and weight) can considerably affect one's risk of developing osteoporosis. Therefore, weight and BMI can be used as to screen those at risk of developing osteoporosis and its related complication.

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Percent body fat, fractures and risk of osteoporosis in women

Cited by 7 publications

References 39 publications

A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats

A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats

Correlation of anthropometric measurements with bone mineral density in south Indian population

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