Perceived Stress and Surgical Wound Cytokine Patterns

Lucas, Valentina; McCain, Nancy L.; Elswick, R. K.; Pozez, Andrea L.

doi:10.1097/psn.0000000000000223

Cited by 6 publications

(5 citation statements)

References 76 publications

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“…Vacuum, drainage, or other external devices were used in 124 of the 280 (44%) studies and thus were the most frequently used methods of sample collection 22–27,29–146 ; the vast majority of sample collections using this method (75%, 103/138), were from surgical wounds (Figure 2B). Three other frequently used methods were extraction from absorbent material (31%, 86/280),…”

Section: Resultsmentioning

confidence: 99%

Wound fluid sampling methods for proteomic studies: A scoping review

Harvey

Mellody

Cullum

et al. 2022

Wound Repair Regeneration

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Understanding why some wounds are hard to heal is important for improving care and developing more effective treatments. The method of sample collection used is an integral step in the research process and thus may affect the results obtained. The primary objective of this study was to summarise and map the methods currently used to sample wound fluid for protein profiling and analysis. Eligible studies were those that used a sampling method to collect wound fluid from any human wound for analysis of proteins. A search for eligible studies was performed using MEDLINE, Embase and CINAHL Plus in May 2020. All references were screened for eligibility by one reviewer, followed by discussion and consensus with a second reviewer.Quantitative data were mapped and visualised using appropriate software and summarised via a narrative summary. After screening, 280 studies were included in this review. The most commonly used group of wound fluid collection methods were vacuum, drainage or use of other external devices, with surgical wounds being the most common sample source. Other frequently used collection methods were extraction from absorbent materials, collection beneath an occlusive dressing and direct collection of wound fluid. This scoping review highlights the variety of methods used for wound fluid collection. Many studies had small sample sizes and short sample collection periods; these weaknesses have hampered the discovery and validation of novel biomarkers. Future research should aim to assess the reproducibility and feasibility of sampling and analytical methods for use in larger longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

Wound fluid sampling methods for proteomic studies: A scoping review

Harvey

Mellody

Cullum

et al. 2022

Wound Repair Regeneration

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“…In women with breast cancer who underwent surgical organ reconstruction after mastectomy, the cytokine profile assessed on the day of surgery and two days later was diverse, i.e., the levels of some immunosuppressive cytokines were higher at the beginning, and subsequently decreased significantly. It should be emphasized that in case of some cytokines evaluated in the WF, their concentration was significantly influenced by the level of stress of the examined patients [242]. Increased stress levels reduce the number of macrophages (CD68 + ), leukocytes (CD45 + ) and Langerhans cells (CD1a + ) and significantly limit the activity of immune cells in the skin by regulating the expression of HLA antigens, which is associated with impaired wound healing.…”

Section: Wound Healingmentioning

confidence: 99%

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance

2020

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Background Tumor initiation and subsequent progression are usually long-term processes, spread over time and conditioned by diverse aspects. Many cancers develop on the basis of chronic inflammation; however, despite dozens of years of research, little is known about the factors triggering neoplastic transformation under these conditions. Molecular characterization of both pathogenetic states, i.e., similarities and differences between chronic inflammation and cancer, is also poorly defined. The secretory activity of tumor cells may change the immunophenotype of immune cells and modify the extracellular microenvironment, which allows the bypass of host defense mechanisms and seems to have diagnostic and prognostic value. The phenomenon of immunosuppression is also present during chronic inflammation, and the development of cancer, due to its duration, predisposes patients to the promotion of chronic inflammation. The aim of our work was to discuss the above issues based on the latest scientific insights. A theoretical mechanism of cancer immunosuppression is also proposed. Conclusions Development of solid tumors may occur both during acute and chronic phases of inflammation. Differences in the regulation of immune responses between precancerous states and the cancers resulting from them emphasize the importance of immunosuppressive factors in oncogenesis. Cancer cells may, through their secretory activity and extracellular transport mechanisms, enhance deterioration of the immune system which, in turn, may have prognostic implications.

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“…There is evidence pointing to a close relationship between stress, behavior, the immune system, and cancer development and progression; this stress response to specific stimuli may initiate a chain of events leading up to a variety of adverse health effects. 5 , 6 , 7…”

Section: Introductionmentioning

confidence: 99%

“…4 There is evidence pointing to a close relationship between stress, behavior, the immune system, and cancer development and progression; this stress response to specific stimuli may initiate a chain of events leading up to a variety of adverse health effects. [5][6][7] Serum cortisol is a biochemical marker of acute and chronic stress and has been used as such, either alone or together with specific questionnaires in clinical and epidemiological studies. 8 The experience of cancer by some individuals causes dysregulation of the HPA axis, leading to changes in cortisol circadian rhythm, which may accelerate tumor progression and reduce the quality of life (QOL).…”

mentioning

confidence: 99%

Nighttime salivary cortisol as a biomarker of stress and an indicator of worsening quality of life in patients with head and neck cancer: A cross‐sectional study

Cruz

Reis

OLIVEIRA

et al. 2022

Health Science Reports

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Background Head and neck cancer (HNC) is a generic term defined on an anatomical–topographic basis to describe malignant tumors located in the oral cavity, pharynx, larynx, and thyroid. A situation commonly presented by individuals with cancer is stress, with evidence indicating a close relationship between stress, behavior, and the immune system with the development and progression of cancer. Aim To assess the association between stress levels and quality of life among individuals with HNC. Methods This was a cross‐sectional study involving 72 HNC patients. The University of Washington Quality of Life Questionnaire was used to assess the quality of life, while the Perceived Stress Scale and salivary cortisol were used to evaluate stress levels. Results A negative association was found between quality of life and stress levels as indicated by both the PSS and nighttime salivary cortisol. Nighttime salivary cortisol showed the best accuracy estimated by the area under the receiver operating characteristic curve, slightly better than that of PSS. Conclusion Among the time points for saliva sampling, nighttime cortisol was found to have the best accuracy, which was similar to that of the PSS, for the detection of patients with the worst quality of life.

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Perceived Stress and Surgical Wound Cytokine Patterns

Cited by 6 publications

References 76 publications

Wound fluid sampling methods for proteomic studies: A scoping review

Wound fluid sampling methods for proteomic studies: A scoping review

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance

Nighttime salivary cortisol as a biomarker of stress and an indicator of worsening quality of life in patients with head and neck cancer: A cross‐sectional study

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