Perceived neuropsychological impairment inversely related to self‐reported health and employment in multiple sclerosis

D'hooghe, Marie B; Cock, Alexander De; Benedict, Ralph H. B.; Gielen, Jeroen; Remoortel, Ann Van; Eelen, Piet; Merhaegen, A. Van; Keyser, Jacques De; D’haeseleer, Miguel; Peeters, Erika; Nagels, Guy

doi:10.1111/ene.14012

Cited by 18 publications

(32 citation statements)

References 28 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most notably, cognitive improvement was not accompanied by a self‐awareness of this positive cognitive change. In keeping with previous research (D'hooghe et al., 2019), we showed that depression influenced how participants perceived their own cognitive abilities, but this does not differ according to cannabis use or abstention.…”

Section: Discussionsupporting

confidence: 92%

Impaired awareness: Why people with multiple sclerosis continue using cannabis despite evidence to the contrary

et al. 2021

View full text Add to dashboard Cite

Background: With widespread moves toward legalization of cannabis, increasing numbers of people with multiple sclerosis (pwMS) are using the drug. Emerging MS-related data show that cannabis can cause or exacerbate cognitive dysfunction.Objective: To understand why people with MS continue using cannabis despite adverse cognitive consequences. It was hypothesized that lack of awareness, a component of metacognition, could explain this decision, in part.Method: Forty pwMS who smoked cannabis almost daily were assigned by odd-even case number selection to either a cannabis continuation (CC) or cannabis withdrawal (CW) group. Both groups were followed for 28 days. All participants completed, at baseline and day 28, the brief repeatable battery of neuropsychological tests (BRNB) in MS for measures of processing speed, memory and executive function; Modified fatigue impact scale (mFIS) for self-report indices of cognitive functioning. Results:No significant baseline differences between the groups on the BRNB and mFIS. At day 28, significant improvement within group was seen on all measures of the BRNB, but only in the CW group (p = .0001 for all indices). A repeat measure ANOVA did not find any significant group (CC vs. CW) × time (baseline and day 28) interactions for the self-report cognitive measures on the mFIS. Cannabis abstainers did report less ability to function away from home. All 19 participants in the CW group reverted to using cannabis on study completion despite being informed individually of their cognitive improvement. Conclusions and relevance:The inability of pwMS to accurately appraise their memory and executive function can help explain, in part, why they continue to smoke cannabis despite objective evidence of the deleterious cognitive side effects of this behavior.

show abstract

Section: Discussionsupporting

confidence: 92%

Impaired awareness: Why people with multiple sclerosis continue using cannabis despite evidence to the contrary

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For a more detailed description of the methods used, we refer to previous publications on this data set. 14,16…”

Section: Methodsmentioning

confidence: 99%

“…For a more detailed description of the methods used, we refer to previous publications on this data set. 14,16 Patients were included if there was a full data set for the screening for depression, EDSS, MSNQ and SDMT scores. One missing value in the MSNQ was imputed by the mean item score.…”

Section: Methodsmentioning

confidence: 99%

“…10-13,15 These observations resulted in the interpretation that elevated scores obtained with the patient-report version are rather explained by depression whereas the informant-report version is considered a sensitive and validated screening tool for CI. 11 Regardless of its link with depression, the impact of subjective cognitive complaints in MS may be substantial, taking into consideration its associations with reduced employment and work performance, 16-17 health-related quality of life, 16 health-promoting behaviours 16,18 and reduced thalamic and cortical grey matter volumes. 19…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13]15 These observations resulted in the interpretation that elevated scores obtained with the patient-report version are rather explained by depression whereas the informant-report version is considered a sensitive and validated screening tool for CI. 11 Regardless of its link with depression, the impact of subjective cognitive complaints in MS may be substantial, taking into consideration its associations with reduced employment and work performance, [16][17] health-related quality of life, 16 health-promoting behaviours 16,18 and reduced thalamic and cortical grey matter volumes. 19 While Kurtzke Expanded Disability Status Scale (EDSS) 20 scores were not taken into account when selecting questions for the MSNQ, 10 later studies included patients with a wide variety of neurological disability, with EDSS scores ranging from 0 to 9.5 and median EDSS values ranging between 2.5 and 5.0.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Correlates of patient-reported cognitive performance with regard to disability

Laethem

Cock

Schependom

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The inconsistent association of patient−reported Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) scores with performance−based cognitive tests in MS could be related to the degree of disability, due to certain MSNQ−questions assuming some self−dependence and intact instrumental ADLs. Objectives: To test whether the relation between subjective and objective cognitive performance could be moderated by physical disability as measured by the Expanded Disability Status Scale (EDSS), we assessed the correlation between MSNQ and Symbol Digit Modalities Test (SDMT) scores in different EDSS groups. Methods: From 288 MS patients who completed the patient−report MSNQ and a two−question screening tool for depression, we also collected SDMT and EDSS scores. We analysed correlations in the total group and three EDSS subgroups: Low 0.0 − 3.0, Medium 3.5 − 6.0 and High 6.5 − 9.5. Results: We found a significant and negative correlation between patient−reported MSNQ scores and SDMT scores in the low EDSS (r = −.225, p = .044), but not in the medium and high EDSS groups, and significant positive correlations between MSNQ and depression in all subgroups. Conclusions: Our data suggest that the patient−report MSNQ has potential as a measure of cognition in patients with low EDSS-scores but not in the medium and high EDSS ranges.

show abstract

Klinische Umsetzbarkeit der kognitiven Screeningbatterie BICAMS bei Patienten mit Multipler Sklerose: Ergebnisse der Machbarkeitsstudie in Deutschland

Penner

Filser

Bätge³

et al. 2021

Nervenarzt

View full text Add to dashboard Cite

Zusammenfassung Hintergrund Patienten mit Multipler Sklerose (MS) leiden in 40–70 % der Fälle unter kognitiven Störungen. Der kognitive Status gilt erwiesenermaßen als Prädiktor für Berufsfähigkeit und frühzeitige Berentung. Eine regelmäßige Erfassung der kognitiven Leistungsfähigkeit ist somit dringend indiziert. Zielsetzung Die deutsche Fassung der international empfohlenen BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) -Batterie wurde auf Praktikabilität in der klinischen Routine neurologischer Praxen in Deutschland multizentrisch überprüft. Material und Methoden Medizinische Fachangestellte (MFAs) wurden hinsichtlich der Durchführung und Auswertung von BICAMS geschult. Alle ausgewerteten Testbögen wurden von unabhängigen neuropsychologischen Experten überprüft. Ergebnisse Insgesamt 1606 BICAMS-Datensätze wurden in 65 Zentren erhoben. Von diesen konnten 1573 analysiert werden. 49,7 % der erhobenen Datensätze wurden inklusive aller Auswerteschritte korrekt durchgeführt. Bei den anderen 50,3 % fanden sich Durchführungs‑, Auswerte- oder Transformationsfehler. Nach Bereinigung der Stichprobe durch fehlerbehaftete Fälle ergaben sich Werte der Interrater-Reliabilität pro Testverfahren in Höhe von ICC $$\geq$$ ≥ 0,953. Diskussion Grundsätzlich ist BICAMS für den Einsatz im klinischen Alltag sehr zu empfehlen. Es bleibt allerdings zu betonen, dass obgleich die Interrater-Reliabilität für die final bereinigte Stichprobe sehr hoch war, im Gesamtdatensatz 50,3 % Durchführungs‑, Auswerte- oder Transformationsfehler gefunden wurden. Daraus lässt sich die Notwendigkeit ableiten, nichtpsychologisches Personal noch eingehender in der Anwendung und Auswertung von BICAMS durch Experten zu schulen und zu supervidieren.

show abstract

Perceived neuropsychological impairment inversely related to self‐reported health and employment in multiple sclerosis

Cited by 18 publications

References 28 publications

Impaired awareness: Why people with multiple sclerosis continue using cannabis despite evidence to the contrary

Impaired awareness: Why people with multiple sclerosis continue using cannabis despite evidence to the contrary

Correlates of patient-reported cognitive performance with regard to disability

Klinische Umsetzbarkeit der kognitiven Screeningbatterie BICAMS bei Patienten mit Multipler Sklerose: Ergebnisse der Machbarkeitsstudie in Deutschland

Contact Info

Product

Resources

About