“…Chemesthetic sensitivity in the mucosae of the human face (nasal, ocular, and oral) is mediated by C and A delta fibers primarily from the trigeminal nerve, although in the case of oral chemesthesis, the glossopharyngeal and vagus nerves also contribute (see reviews in Doty and Cometto-Muñiz, 2003;Doty et al, 2004;Rentmeister-Bryant and Green, 1997). The ion-channels and receptors involved are expressed by a class of peripheral neurons called polymodal nociceptors since they can respond to chemical, thermal, and mechanical stimuli (Belmonte et al, 2004).…”