“…These changes seem to occur within 10 years after arrival, but are often most dramatic in recently arrived individuals (Newbold, 2005); this phenomenon is not restricted to young people but occurs also in adults (Kalyoncu & Stålenheim, 1992). This immunomodulation by cultural adaptation—which goes together with changes in disease susceptibility—seems to be a universal phenomenon for various inflammatory diseases, including asthma and allergies (Grüber et al , 2002; Kalyoncu & Stålenheim, 1992), autoimmune diseases (Bodansky et al , 1992), obesity and type 2 diabetes (Creatore et al , 2010), depression (Casimir et al , 2010) and cancer (Pinheiro et al , 2009). The disease spectrum is similar to that associated with altered gut microbiota, as discussed above.…”