Perceived fatigue in multiple sclerosis: The importance of highlighting its impact on quality of life, social network and cognition

Eizaguirre, María Bárbara; Ciufia, Natalia; Roman, María Sol; Canyazo, Carlos Martínez; Alonso, Ricardo; Silva, Berenice; Pita, Cecilia; Garcea, Orlando; Vanotti, Sandra

doi:10.1016/j.clineuro.2020.106265

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…The mean age of the study population was 40 AE 10.5 years (range 18-60), the mean EDSS score was 2.43 AE 1.87 and the disease duration 10 AE 7 years. 32 In a study validating the Finnish version of FSS from 2017 Rosti-Otaj€ arvi and colleagues found a prevalence of fatigue of 65% (FSS !4). The mean age of the study population was 54 AE 11.4 years and the mean patient assessed EDSS score 4.0 AE 2.5.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of fatigue in contemporary patients with multiple sclerosis

Broch¹,

Simonsen²,

Flemmen

et al. 2021

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Objective The prevalence of multiple sclerosis (MS)-related fatigue may have changed due to new diagnostic criteria and new disease modifying drugs. We aimed to assess the prevalence of fatigue in a contemporary MS cohort, and to explore associations between fatigue and clinical and demographic factors. Methods This is a cross-sectional study of the MS population in three Norwegian counties. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC). We also assessed self-reported anxiety, depression and daytime sleepiness. Results The response rate was 64% (1599/2512). The mean age of the participants was 52 ± 13 years, median EDSS was 2.5 (IQR 1.5-3.0) and median disease duration from onset was 16 years (IQR 8-25). We found a prevalence of fatigue of 81%. Women had a higher prevalence of fatigue than men (83% vs 78%, p = 0.02). The prevalence increased with age (p < 0.001) and with increasing disease severity (p < 0.001), but in multivariate analyses, only sex and disease severity remained independent determinants of fatigue. Anxiety, depression, and daytime sleepiness were more prevalent in patients with fatigue than in those without fatigue (all p-values < 0.001). Conclusion The prevalence of fatigue is high in contemporary patients with MS. Fatigue is associated with female sex and level of disability, as well as with anxiety, depression and excessive daytime sleepiness.

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Section: Discussionmentioning

confidence: 99%

High prevalence of fatigue in contemporary patients with multiple sclerosis

Broch¹,

Simonsen²,

Flemmen

et al. 2021

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…This may explain why pwMS with these symptoms in particular are seeking more PPS, especially when bother from these symptoms in particular reaches a level that cannot be managed with support from other sources such as friends and family, MS peers, MS nurses and MS charities and organisations (Morris-Bankole and Ho, 2022). It is therefore of little surprise that higher levels of fatigue in pwMS has been linked to lower health related quality of life and having less friends in social networks (Eizaguirre et al, 2020). Similarly, depression and psychological distress have been found to be amongst factors that have the strongest impact on subjective well-being in pwMS (Yalachkov et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Psychotherapy and professional psychological support in multiple sclerosis: Uncovering patients’ patterns of access and preferences

Morris-Bankole¹,

Ho²

2023

Multiple Sclerosis and Related Disorders

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“…Fatigue was quantified in 7 out of 17 studies (Rasova et al, 2005;Tavazzi et al, 2018;Akbar et al, 2020;Boffa et al, 2020;Peran et al, 2020;Stellmann et al, 2020;Zuber et al, 2020), and is another element that should be assessed in patients undergoing neuromotor rehabilitation. Fatigue is one of the most common and disabling symptoms affecting pwMS, negatively impacting quality of life and disease evolution (Eizaguirre et al, 2020;Vaughn et al, 2020), as well as reducing overall physical activity. Fatigue has a neuroimaging correlate, being associated with altered FC within the sensorimotor networks, and hyperactivation of different brain regions, such as the primary motor area (Bertoli and Tecchio, 2020).…”

Section: Other Factorsmentioning

confidence: 99%

Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis: A Systematic Review on MRI Markers of Functional and Structural Changes

et al. 2021

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Background: Motor rehabilitation is routinely used in clinical practice as an effective method to reduce progressive disability gain in multiple sclerosis (MS), but rehabilitation approaches are typically unstandardized, and only few studies have investigated the impact of rehabilitation on brain neuroplasticity.Objective: To summarize and critically analyze studies applying MRI markers of functional connectivity and structural changes to assess the effect of motor rehabilitation on brain neuroplasticity in MS.Methods: Literature search was performed using PubMed and EMBASE, selecting studies having as a subject motor rehabilitation and advanced MRI techniques investigating neuroplasticity in adult patients affected by MS.Results: Seventeen out of 798 papers were selected, of which 5 applied structural MRI (4 diffusion tensor imaging, 1 volumetric measurements), 7 applied functional fMRI (5 task-related fMRI, 2 resting-state fMRI) whereas the remaining 5 applied both structural and functional imaging.Discussion: The considerable data heterogeneity and the small sample sizes characterizing the studies limit interpretation and generalization of the results. Overall, motor rehabilitation promotes clinical improvement, paralleled by positive adaptive brain changes, whose features and extent depend upon different variables, including the type of rehabilitation approach. MRI markers of functional and structural connectivity should be implemented in studies testing the efficacy of motor rehabilitation. They allow for a better understanding of neuroplastic mechanisms underlying rehabilitation-mediated clinical achievements, facilitating the identification of rehabilitation strategies tailored to patients' needs and abilities.

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Perceived fatigue in multiple sclerosis: The importance of highlighting its impact on quality of life, social network and cognition

Cited by 12 publications

References 29 publications

High prevalence of fatigue in contemporary patients with multiple sclerosis

High prevalence of fatigue in contemporary patients with multiple sclerosis

Psychotherapy and professional psychological support in multiple sclerosis: Uncovering patients’ patterns of access and preferences

Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis: A Systematic Review on MRI Markers of Functional and Structural Changes

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