“…They are also the second most common drug class through which Americans are initiated into illicit drug use; while 2.4 million Americans over the age of 12 were initiated into illicit drug use through marijuana in 2013, 1.5 million people reported that the first drug they ever tried was a PO (SAMHSA, 2014). Research has found that young adults frequently use POs nonmedically with peers in social settings (e.g., at parties, while hanging out with friends) and young people report using POs to reduce anxiety, facilitate social interactions, enhance sexual experiences, and intensify the effects of other substances (Mateu-Gelabert, Guarino, Jessell, & Teper, 2015; McCabe, Cranford, Boyd, & Teter, 2007; Silva, Kecojevic, & Lankenau, 2013). When taken in large doses or in combination with other substances (e.g., benzodiazepines, alcohol), the effects of POs may lead to drowsiness, impaired judgment, incapacitation, loss of consciousness, and overdose (Frank etal., 2015; Jones, Mogali, & Comer, 2012; Lipman, 2010; Mateu-Gelabert et al, 2015).…”