Perceived Anxiety, Coping, and Autonomic Function in Takotsubo Syndrome Long after the Acute Event

Lazzeroni, Davide; Ciracì, Chiara; Oggioni, Carlotta; Saccò, Melissa; Ziveri, Valentina; Paglialonga, Letizia; Bini, Matteo; Moderato, Luca; Brambilla, Lorenzo; Coruzzi, Paolo; Cruciani, Gianluca; Lingiardi, Vittorio; Tanzilli, Annalisa; Galli, Federica

doi:10.3390/life12091376

Cited by 4 publications

(20 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A larger proportion of TTS patients had psychiatric disorders and neurological diseases compared with ACS patients 35 . Another study corroborates that ACS patients were less often affected by psychological disorders compared with TTS patients 15 . Similarly, another study found a higher frequency of TDP patients with emotionally triggered TTS compared with patients who had had an MI 18 .…”

Section: Risk Factorsmentioning

confidence: 64%

“…35 Another study corroborates that ACS patients were less often affected by psychological disorders compared with TTS patients. 15 Similarly, another study found a higher frequency of TDP patients with emotionally triggered TTS compared with patients who had had an MI. 18 Ugo et al found that anxiety disorders were more prevalent in TTS patients, with depressive disorders being more prevalent in ACS patients.…”

Section: Takotsubo Syndrome Vs Acute Coronary Syndrome Pathophysiologymentioning

confidence: 93%

“…Black arrows highlight where the TTS and ACS pathology is within the heart structure. The diagram depicts the apical ballooning subtype of TTS, but there are others identified 15 …”

Section: Risk Factorsmentioning

confidence: 99%

“…The overarching factor for TTS development is stress; physical or psychological. 15 Biologically, stress manifests as a rise in hormones such as cortisol and catecholamines. 16,17 Stress preceding TTS may be acute or from chronic events and may coincide.…”

Section: Stressmentioning

confidence: 99%

“…25 Studies have found that generally, patients with dysfunctional psychological coping mechanisms were found to be at an increased risk of TTS. 15 Furthermore, TDP is itself associated with maladaptive coping. 24 Likewise, individuals with preexisting mental health problems such as depression and anxiety were more prone to TTS compared with their counterparts.…”

Section: Stressmentioning

confidence: 99%

See 4 more Smart Citations

An update on takotsubo syndrome

Alim,

Shah,

Zahera

et al. 2023

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

Takotsubo syndrome (TTS) can be described as an acute, transiently occurring form of heart failure. It typically causes systolic dysfunction of the left ventricle (LV). Perhaps what is of most significance is the reversible nature of TTS, with many patients achieving recovery within a few weeks to months. TTS can be referred to by other names, attributed to its various precipitants, as well as the structural manifestations of the syndrome. Physical and emotional stressors have been identified as the most common of causes, hence the terms ‘stress cardiomyopathy’ and ‘broken heart syndrome’. Precipitants can range from psychological, and hormonal, to molecular mechanisms. The symptoms of TTS can coalesce with other conditions and hence give rise to many differential diagnoses. Most patients present with dyspnoea and chest pain. The latter also presents in acute coronary syndrome (ACS); thus, ACS is a common differential diagnosis for TTS. The coronavirus disease 2019 (COVID-19) pandemic saw a drastic increase in mental health concerns which have persisted beyond this period. Further studies into personality disorders and their potential predisposition to COVID-19 and thus TTS would advance our understanding of the neuropsychiatric triggers of TTS. There is also a need for a single sensitive and specific diagnostic test for TTS as its diagnosis relies on the culmination of clinical presentation, echocardiography, cardiac catheterization, and cardiovascular magnetic resonance imaging (CMR).

show abstract

Section: Risk Factorsmentioning

confidence: 64%

Section: Takotsubo Syndrome Vs Acute Coronary Syndrome Pathophysiologymentioning

confidence: 93%

“…Black arrows highlight where the TTS and ACS pathology is within the heart structure. The diagram depicts the apical ballooning subtype of TTS, but there are others identified 15 …”

Section: Risk Factorsmentioning

confidence: 99%

Section: Stressmentioning

confidence: 99%

Section: Stressmentioning

confidence: 99%

See 3 more Smart Citations

An update on takotsubo syndrome

Alim,

Shah,

Zahera

et al. 2023

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

show abstract

Heart rate variability alterations in takotsubo syndrome and related association with psychological factors: a systematic review and meta-analysis

Cruciani,

Cavicchioli,

Tanzilli

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

Psychological factors may have a precipitant role in takotsubo syndrome (TS). Aberrant Heart Rate Variability (HRV) has been reported in TS, suggesting inflexibility of the autonomous nervous system. Nevertheless, results on HRV alterations and their link with psychological factors in TS are conflicting. This work aimed to systematically explore whether TS may be associated with HRV alterations and their association with specific psychological profiles in TS patients. A literature search was conducted across databases (Pubmed, Scopus, PsycInfo, Web of Science) and empirical studies including TS patients which were evaluated in one or more HRV indices were retrieved. HRV and psychological outcomes were extracted. 10 empirical studies with 194 TS patients were included. Results showed significant alteration of HRV in TS patients, with indices compared to controls, and a progressive increase over time. Nevertheless, retrieved data presented mixed results, as also shown by a large heterogeneity in the meta-analytic findings. 2 studies found significant relationships between HRV alterations and trait—rather than state—psychological outcomes (i.e., coping strategies and emotional arousal), pointing to the need to explore the role of psychological vulnerabilities, rather than single traumatic stressors, in the association between HRV and TS.

show abstract

Psychological features of patients with Takotsubo syndrome: cross-sectional study

et al. 2023

View full text Add to dashboard Cite

Objective. We aimed to assess the psychological state and personality-adaptive potential in patients with Takotsubo syndrome (TS), and to use the results to construct a prognostic model for the risk of developing the disease. Materials and methods. A total of 38 patients with TS were examined 1014 days after the disease onset. The mean age of the men was 63.814.73 years, and the women, 33 (86.8%) years. The control group included 40 people; their average age was 66.610.4 years, of which 39 (97.5%) were women. Their psychological state and stress resistance were assessed using the following tests and questionnaires: G. Eysenck's personality questionnaire; the hardiness survey; the N.V. Kirsheva and N.V. Ryabchikov personality stress resistance self-test; the scale of perceived stress; the PSM-25 LemurTessierFillion psychological stress measure; the SpielbergerKhanin anxiety scale; the Hamilton Anxiety Scale; the Hospital Anxiety and Depression scale; the Beck Depression Scale; and the MontgomeryAsberg depression rating scale. Results. G. Eysenck's personality questionnaire showed that patients with TS had a higher level of neuroticism (14.63.7 and 11.44.1, respectively; p 0.01) and tendency to introversion (9.43.3 and 12.43.5, respectively; p 0.001) than the control group. According to the SpielbergerKhanin psychometric scale, reactive anxiety was higher in the TS group (46.49.1 and 37.011.4, respectively; p 0.0001), and there was also a tendency toward personal anxiety (45.17.3 and 41.811.1, respectively; p 0.05). For all three analyzed scales designed to assess internal anxiety, it was found that in patients with TS, this component of the psyche was more pronounced (HARS: 21.84.8 and 16.15.4, respectively; p 0.0001; HADS: 13.13.6 and 7.43.0, respectively; p 0.0001). Depression, ranging from mild to severe, was more common in patients with TS, according to all questionnaires (HADS: 100% and 40%, respectively; p 0.05; BDI: 73.7% and 27%, respectively; p 0.05; MADRS: 97.4% and 62.5%, respectively, p 0.05). According to the hardiness test, the TS group had low indicators of overall hardiness (71.418.0 and 82.619.7, respectively; p 0.05), involvement (32.59.1 and 36.88.9, respectively; p 0.05), and control (23.37.3 and 29.27.8, respectively; p 0.01) compared to the control group. Stress resistance was also significantly lower in patients with TS (38.96.4 and 34.17.3, respectively; p 0.001). Based on the data from the questionnaires and scales, using the classification tree method, an integral model for predicting the development of TS with a high predictive value (96%) was built. Conclusion. Anxiety and depressive disorders make a significant contribution to the development of TS. Personality traits like introversion, neuroticism, and increased susceptibility to stress with low stress resistance and hardiness also play a role. This suggests the need for timely diagnosis of psychological disorders and their correction in people with this personality type, especially postmenopausal women. Prompt intervention may help prevent or reduce the risk of developing the disease.

show abstract

Perceived Anxiety, Coping, and Autonomic Function in Takotsubo Syndrome Long after the Acute Event

Cited by 4 publications

References 49 publications

An update on takotsubo syndrome

An update on takotsubo syndrome

Heart rate variability alterations in takotsubo syndrome and related association with psychological factors: a systematic review and meta-analysis

Psychological features of patients with Takotsubo syndrome: cross-sectional study

Contact Info

Product

Resources

About