PERBANDINGAN PROSES PENYEMBUHAN TULANG ANTARA IMPLANTASI HIDROKSIAPATIT NANOKRISTALIN  DAN HIDROKSIAPATIT MIKROKRISTALIN (Kajian pada tulang tibia kelinci

Pascawinata, Andries; Prihartiningsih, Prihartiningsih; Dwirahardjo, Bambang

doi:10.33854/jbdjbd.45

Cited by 3 publications

(5 citation statements)

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“…Compared to nano-HA, microcrystalline HA has a low level of solubility, so it is not easily absorbed. Based on a study conducted by Pascawinata et al 14 , when implanted in bone defects, this HA can be well covered and even partially replaced by new bone. However, the resorption process takes a long time and is still seen in the experimental animal after nine months.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoblasts and osteoclasts that adhere more to the nanocrystalline HA accelerate the healing process of bone injuries. 14 As well as the particle size, tooth graft powder also contains some beneficial components for cell proliferation. Ninety percent of the organic components of teeth are type I collagen and contain growth factors such as IGF-II, BMP2, and bone-like TGF-beta.…”

Section: Discussionmentioning

confidence: 99%

“…BMP2 is present in the enamel and is potentially osteoinductive. 14 Cementum and dentin have other growth factors, including plateletderived growth factor, IGF, and fibroblast growth factor. According to research, autogenous demineralized dentin matrix is chemotactic for osteoprogenitor cells and osteoblasts, encouraging the faster process of bone repair in bone defects.…”

Section: Discussionmentioning

confidence: 99%

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The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Kumala,

Fauzia,

Junivianti

2023

Dent. J.

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Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Kumala,

Fauzia,

Junivianti

2023

Dent. J.

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“…Osteoblasts will secrete TGF-β1 during the proliferation stage, and then TGF-β1 will again stimulate osteoblasts through the autocrine effect [11]. Level of ALP in the treatment group was higher than in the control group because hydroxyapatite has good quality of osteoconduction, osteoinduction, and osteointegration [28]. Hydroxyapatite gel in the socket will stimulate the release of cytokines from endothelial cells through inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Kamadjaja¹,

Tumali²,

Laksono³

et al. 2020

Recent Advances in Biology and Medicine

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Tooth extraction can cause 1.5-2 mm (vertical) and 40-50% (horizontal) alveolar bone resorption to occur for 6 months after extraction and will continue if it is not treated. Alveolar bone resorption will affect the retention, stability, and comfort in the use of dentures because adequate alveolar bone volume and structure of alveolar ridge are very important to obtain optimal function and prosthetic reconstruction. Currently, there are techniques and materials that can be used to minimize bone resorption. Preservation of alveolar ridges with crab shell-based hydroxyapatite can minimize bone resorption because it has good biocompatibility, osteoconduction, and osteoinduction. The aim of this study is to prove the effectiveness of hydroxyapatite from crab shells in increasing the area of bone trabeculae, transforming growth factor-beta 1(TGF-β1), and alkaline phosphatase (ALP). This laboratory research is an experimental laboratory work with a post-test group design. Crab shell-based hydroxyapatite gel (Portunus pelagicus) was given after the post-tooth socket extraction of the left lower central incisor of Wistar rats, observing the area of trabeculae, TGF-β1, and ALP on the 14th day and 28th day. Hydroxyapatite is made from the calcination process of crab shells using a furnace at 1000°C for 2 h followed by sifting to powder. The powder is added with carrageenan and distilled water so that it becomes a gel preparation. The results of this study were analyzed using the One-way ANOVA test with IBM SPSS version 20. The area of trabeculae, TGF-β1, and ALP between the control group and the treatment group showed p<0.05, which means there were significant differences between the groups. The study showed that hydroxyapatite from the crab shell (P. pelagicus) can increase the area of trabeculae, TGF-β1, and ALP in the post-extraction socket of Wistar rat’s teeth.

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“…The attachment of osteoblasts and osteoclasts is known to occur more in nanocrystalline HA than conventional HA [35]. Pascawinata et al (2013) study showed more and faster bone healing in defects implanted using nanocrystalline HA than conventional HA and defects left blank [36]. The advantages of nanocrystalline HA as bone graft material are its closer contact with the surrounding tissue, its faster absorption, and the high number of molecules on its surface.…”

Section: Ha Nanocrystallinementioning

confidence: 97%

Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin on Bone Graft Materials for Alveolar Bone Preservation

Pascawinata

Bakar

2022

Open Access Maced J Med Sci

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Alveolar bone resorption is one of post-extraction complications with a reduction in the dimensions and quality of the alveolar bone, which will make it challenging to install dental implants in the future. The resorption can be prevented by preserving the alveolar bone using bone grafts. Nanocrystalline hydroxyapatite (HA) is a widely developed material as a bone graft. However, there are still some limitations because it only has osteoconductive properties. The addition of injectable platelet-rich fibrin to HA can increase this material’s osteoinductive, antibacterial, and anti-inflammatory properties, making it suitable for use as bone graft material for the preservation of alveolar bone.

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PERBANDINGAN PROSES PENYEMBUHAN TULANG ANTARA IMPLANTASI HIDROKSIAPATIT NANOKRISTALIN DAN HIDROKSIAPATIT MIKROKRISTALIN (Kajian pada tulang tibia kelinci

Cited by 3 publications

References 0 publications

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin on Bone Graft Materials for Alveolar Bone Preservation

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