Per3 VNTR polymorphism and chronic heart failure

Abstract

Aims. The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF). Methods. The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. Results. No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (P g =0.30, P a =0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; P g =0.87, P a =0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found. Conclusion. Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.

Possible Association ofPER2/PER3Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer

“…No significant difference was observed in allele periodicities of PER3 VNTR between the obese and the nonobese individuals (Bienertova-Vasku et al, 2014). In addition, there was no significant difference between chronic heart failure patients and controls regarding PER3 VNTR allele and genotype frequencies (Lipkova et al, 2014a). Geng et al (2015) found a moderate increase in risk of cancer among individuals with the PER3 VNTR 5 allele compared to individuals with the 4 allele in a meta-analysis.…”

Associations of PER3 polymorphisms with clopidogrel resistance among Chinese Han people treated with clopidogrel

“…33 Furthermore, the PER3 clock gene is part of the circadian clock transcription/translation feedback loop and encodes a protein involved in sleep regulation. 17 PER3 has been studied concerning heart tissue and heart diseases, 21,[34][35][36] and SNPs of the PER3 gene have been confirmed to play an important role in the endocrine system and psychological disease progression. For example, effects on depression and anxiety symptoms 37 and melaton in treatment, 38 analysis of Graves' disease susceptibility, 39 and even effects on tumors such as breast cancer 40 have been proven in previous studies.…”