Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling

Kim, Mikyung; Custodio, Raly James Perez; Lee, Hyun Jun; Sayson, Leandro Val; Ortiz, Darlene Mae; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon

doi:10.1007/s12035-022-02845-z

Cited by 10 publications

(3 citation statements)

References 60 publications

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“…Besides, 40hz light icker stimulation induced cognition-related genes, including Arc and Per2. The Arc gene (also known as Arg3.1) is a main player in both synaptic plasticity processes that could sustain learning and memory-related cognitive processes [40]; the Per2 gene KO mice exhibited impaired spatial working memory indicating that Per2 expression levels might in uence spatial working memory performance [41], con rming that the 40hz light icker mechanism may be related to the regulation of cognitive function in CCH mice.…”

Section: Discussionmentioning

confidence: 98%

Effect of 40hz Light Flicker on Cognitive Impairment and Transcriptome of Hippocampus in Right Unilateral Common Carotid Artery Occlusion Mice

Niu,

Yu,

et al. 2023

Preprint

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Vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) seriously affects the living quality in elderly patients. However, there has been no effective treatment to control this disease. This study investigated the potential neuroprotective effect of the 40hz light flicker in a mouse model of CCH. CCH was induced in male C57 mice by right unilateral common carotid artery occlusion (rUCCAO), leading to chronic brain injury. The mice underwent 40hz light flicker stimulation for 30 days after surgery. The results showed that 40hz light flicker treatment ameliorated the memory deficits after rUCCAO and alleviated the damage to neurons in the frontal lobe and hippocampus. Light flicker administration at 40hz decreased IL-1β and TNF-α levels in the frontal lobe and hippocampus, although immunohistochemistry found that it did not exert angiogenesis in mice with rUCCAO. Gene expression profiling revealed that the induction of genes was mainly enriched in inflammatory-related pathways. Our findings demonstrate that 40hz light flicker can suppress cognitive impairment caused by rUCCAO and that this effect is may be invovled in the attenuation of neuroinflammation.

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Section: Discussionmentioning

confidence: 98%

Effect of 40hz Light Flicker on Cognitive Impairment and Transcriptome of Hippocampus in Right Unilateral Common Carotid Artery Occlusion Mice

Niu,

Yu,

et al. 2023

Preprint

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show abstract

“…In addition, 40 Hz light flicker stimulation induced cognition-related genes, including Arc and Per2. The Arc gene (also known as-Arg3.1) is a main player in both synaptic plasticity processes that can sustain learning and memory-related cognitive processes 42 ; Per2 KO mice exhibited impaired spatial working memory, indicating that Per2 expression levels might influence spatial working memory performance 43 , confirming that the 40 Hz light flicker is beneficial to cognitive function in CCH mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of 40 Hz light flicker on cognitive impairment and transcriptome of hippocampus in right unilateral common carotid artery occlusion mice

Niu,

Yu,

et al. 2023

Sci Rep

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Vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) seriously affects the quality of life of elderly patients. However, there is no effective treatment to control this disease. This study investigated the potential neuroprotective effect of the 40 Hz light flicker in a mouse model of CCH. CCH was induced in male C57 mice by right unilateral common carotid artery occlusion (rUCCAO), leading to chronic brain injury. The mice underwent 40 Hz light flicker stimulation for 30 days after surgery. The results showed that 40 Hz light flicker treatment ameliorated memory deficits after rUCCAO and alleviated the damage to neurons in the frontal lobe and hippocampus. Light flicker administration at 40 Hz decreased IL-1β and TNF-α levels in the frontal lobe and hippocampus, but immunohistochemistry showed that it did not induce angiogenesis in mice with rUCCAO. Gene expression profiling revealed that the induction of genes was mainly enriched in inflammatory-related pathways. Our findings demonstrate that 40 Hz light flicker can suppress cognitive impairment caused by rUCCAO and that this effect may be involved in the attenuation of neuroinflammation.

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“…Previous studies have shown that the core‐clock genes Clock , Bmal1 , and Per1/2 are involved in regulating behavioral outputs within the CNS (Snider et al, 2018 ; Vadnie & McClung, 2017 ). For example, mice with a Clock deletion exhibited altered reward‐related behavior and impulsivity, pointing to other mood or behavioral changes such as hyperactivity (Spencer et al, 2012 ), while Per2 knockout mice displayed impairments in spatial learning and memory, and elevated expression of Drd1 gene (Kim et al, 2022 ). Bmal1 knockout mice showed altered circadian patterns of locomotor activity and behavioral changes such as impairment to habitual adaptation (Kondratova et al, 2010 ).…”

Section: A Link Between the Circadian Clock And Agingmentioning

confidence: 99%

Circadian regulation in aging: Implications for spaceflight and life on earth

et al. 2023

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Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as “red flag” risks among astronauts during and after a long‐term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space‐related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus on the four most affected systems: visual, cardiovascular, central nervous, and musculoskeletal systems. In this review, we briefly introduce the regulatory role of the circadian clock in specific cellular processes followed by alterations in those processes due to aging. We next summarize the known molecular alterations associated with spaceflight, highlighting involved clock‐regulated genes in space flown Drosophila, nematodes, small mammals, and astronauts. Finally, we discuss common genes that are altered in terms of their expression due to aging on Earth and spaceflight. Altogether, the data elaborated in this review strengthen our hypothesis regarding the timely need to include circadian dysregulation as an emerging hallmark of aging on Earth and beyond.

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Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling

Cited by 10 publications

References 60 publications

Effect of 40hz Light Flicker on Cognitive Impairment and Transcriptome of Hippocampus in Right Unilateral Common Carotid Artery Occlusion Mice

Effect of 40hz Light Flicker on Cognitive Impairment and Transcriptome of Hippocampus in Right Unilateral Common Carotid Artery Occlusion Mice

Effect of 40 Hz light flicker on cognitive impairment and transcriptome of hippocampus in right unilateral common carotid artery occlusion mice

Circadian regulation in aging: Implications for spaceflight and life on earth

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