Per- and polyfluoroalkyl substances (PFASs) in the blood of police and Beagle dogs from Harbin, China: Concentrations and associations with hematological parameters

You, Dan; Chang, Xiaochen; Guo, Linlin; Xie, Wei; Huang, Shuping; Li, Xiang; Chai, Hongliang; Wang, Yajun

doi:10.1016/j.chemosphere.2022.134367

Cited by 8 publications

(12 citation statements)

References 49 publications

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“…For example, PFNA and perfluorodecanoic acid (PFDA) were both significantly associated with an increase in cholesterol while PFOA and PFOS were significantly associated with a decrease in cholesterol. 51 Only 2 of the species measured, 6:2 chlorinated polyfluorinated ether sulfonate and PFDA, were associated with significant differences Figure 3-Major organs affected by PFAS can differ depending on species and sex. To date, PFAS has been linked to developmental delays, liver damage, immune suppression, some cancers, and disruption of the endocrine system in humans.…”

Section: Pfas Levels and Increased Liver Enzymes (Aspartate Aminotran...mentioning

confidence: 99%

“…However, work has been done examining the amount and types of PFAS in dog sera. A study 51 conducted with laboratory beagles and police dogs in China found a number of PFAS species in all of the sera tested. The average concentration of PFAS was 3.553 ng/ml with PFOA the most common PFAS found, followed by PFBA and PFOS.…”

Section: Are Serum Pfas Levels In Dogs and Cats Comparable To Humans?mentioning

confidence: 99%

“…PFAS exposure in companion animals may impact body condition scores, blood chemistry levels, fetal development, as well as multiple body systems (hepatic, respiratory, immunological, amongst others). 18,50,51,53,54 To date, PFAS has been significantly linked to changes in kidney and liver function in both dogs 51 and cats 20,54 and has been positivily associated with obesity, 20 pleural effusion, 20 and altered thyroid function 20,50,54 in cats (Figure 3).…”

Section: Can Dog and Cat Exposure To Pfas Be Diagnosed From Blood Che...mentioning

confidence: 99%

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Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets

Brake

Wilkins

Kaneene

2023

ajvr

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One of the important human health benefits of keeping pets may be to serve as an early warning system for indoor childhood exposure to toxic chemicals such as per- and polyfluoroalkyl substances (PFAS). The stain-resistant properties and environmental stability of PFAS make them a preferred choice for protective coatings and lubricants, and they have been used for years in various manufacturing and industrial processes around the world. Although the use of PFAS has arguably improved many commercial products, they have been linked to adverse health outcomes such as developmental delays, liver damage, immune suppression, disruption of endocrine and reproductive systems, and some cancers. The current body of literature suggests that serum PFAS levels in dogs and cats are analogous to their human counterparts and that household pets experience similar changes in blood chemistry markers. The proximity of small children and household pets to PFAS-treated carpets and floors, in addition to their tendency to put things into their mouths, potentially allows pets to serve as sentinels for household PFAS exposure. To assess the suitability of pets as indicators for exposure, researchers need to understand the most likely sources of PFAS exposure for household pets and identify the biomarkers of biological effects in those animals. Understanding these parameters may alert veterinary clinicians to potential sources of contamination in the home and ultimately protect the lives of the children and animals who live there.

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Section: Pfas Levels and Increased Liver Enzymes (Aspartate Aminotran...mentioning

confidence: 99%

Section: Are Serum Pfas Levels In Dogs and Cats Comparable To Humans?mentioning

confidence: 99%

Section: Can Dog and Cat Exposure To Pfas Be Diagnosed From Blood Che...mentioning

confidence: 99%

See 1 more Smart Citation

Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets

Brake

Wilkins

Kaneene

2023

ajvr

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“…High PFOS levels were detected among dogs in a veterinary clinic in Japan, but the health status and history of these animals and the effect of PFOS on their health were not evaluated. 35 A study 41 of police dogs exposed to PFAS-containing firefighting foams and laboratory Beagles exposed to PFAS in their diet found dose-dependent alterations in amylase (increased) and cholesterol (decreased). There were also links between PFAS exposure and certain blood chemistry parameters such as the albuminto-globulin ration, BUN, ALP, and creatinine.…”

Section: Adverse Health Effectsmentioning

confidence: 99%

“…There were also links between PFAS exposure and certain blood chemistry parameters such as the albuminto-globulin ration, BUN, ALP, and creatinine. 41 With additional research, possible associations between PFAS and certain disease states might be discovered, which would prove beneficial to veterinarians and clients in understanding the etiology of health conditions in pets.…”

Section: Adverse Health Effectsmentioning

confidence: 99%

Current per- and polyfluoroalkyl substance (PFAS) research points to a growing threat in animals

Brake

Langfeldt

Kaneene

et al. 2023

javma

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Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals that are colorless, odorless, and oil and water repellent. Their widespread use in manufacturing and industrial processes has resulted in environmental contamination found across the world. Exposure to PFAS can lead to a variety of adverse human health outcomes such as increased cholesterol, liver damage, immune suppression, and disruption of endocrine and reproductive systems. Exposure to this family of chemicals is considered a significant public health threat. Though nearly every human and animal around the world has been exposed, most of what is known regarding health effects and toxicological processes of PFAS in animals stems from human epidemiological and laboratory animal studies. Discoveries of PFAS contamination on dairy farms and concerns for companion animals have increased interest in PFAS research related to our veterinary patients. In the limited studies published to date, PFAS has been demonstrated in serum, liver, kidneys, and milk of production animals and has been linked to changes in liver enzymes, cholesterol levels, and thyroid hormones in dogs and cats. This is further addressed in the companion Currents in One Health by Brake et al, AJVR, April 2023. There is a gap in understanding the routes of exposure, absorption of PFAS, and adverse health effects among our veterinary patients. The purpose of this review is to summarize the current literature on PFAS in animals and discuss the implications for our veterinary patients.

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Poly- and perfluoroalkyl substances (PFASs) in amphibians and reptiles – exposure and health effects

Gonkowski,

Ochoa-Herrera

2024

Aquatic Toxicology

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Per- and polyfluoroalkyl substances (PFASs) in the blood of police and Beagle dogs from Harbin, China: Concentrations and associations with hematological parameters

Cited by 8 publications

References 49 publications

Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets

Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets

Current per- and polyfluoroalkyl substance (PFAS) research points to a growing threat in animals

Poly- and perfluoroalkyl substances (PFASs) in amphibians and reptiles – exposure and health effects

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