Per- and polyfluoroalkyl substances (PFAS) in livestock and game species: A review

Death, Clare; Bell, Cameron P. M.; Champness, David; Milne, Charles M.; Reichman, Suzie M.; Hagen, Tarah

doi:10.1016/j.scitotenv.2020.144795

Cited by 126 publications

(89 citation statements)

References 101 publications

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“…Indeed, a slow dissolution process could lead to a slow accumulation and metabolization as well as to an increase in the half-life of PFCs (due to the replacement of consumed PFC by newly dissolved PFC). In this context it is important to highlight that, in addition to the high absorption rate of PFCs in organic matter dispersed in water and aquatic species, the ubiquity and persistence of PFCs in water, e.g., about 40 and 90 years for perfluorooctanoic acid (PFOA) and PFOS, respectively, make these molecules difficult to eradicate [62,63]. Inside an aquatic organism, the half-life can depend on the type of metabolism and is more sensitive to the type of functional groups.…”

Section: Solubility Persistence and Aquatic Half-life Of Pfcsmentioning

confidence: 99%

“…Inside an aquatic organism, the half-life can depend on the type of metabolism and is more sensitive to the type of functional groups. For instance, the presence of sulfonic or carboxylic acid moieties can increase the half-life of the substance (regardless of the carbon chain length) [63]. The half-life, is also affected by the type of isomer, as seen for PFOA's and perfluorononanoic acid's (PFNA) isomers in rainbow trout [64].…”

Section: Solubility Persistence and Aquatic Half-life Of Pfcsmentioning

confidence: 99%

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Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Savoca

Pace

2021

IJMS

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This review is a survey of recent advances in studies concerning the impact of poly- and perfluorinated organic compounds in aquatic organisms. After a brief introduction on poly- and perfluorinated compounds (PFCs) features, an overview of recent monitoring studies is reported illustrating ranges of recorded concentrations in water, sediments, and species. Besides presenting general concepts defining bioaccumulative potential and its indicators, the biodistribution of PFCs is described taking in consideration different tissues/organs of the investigated species as well as differences between studies in the wild or under controlled laboratory conditions. The potential use of species as bioindicators for biomonitoring studies are discussed and data are summarized in a table reporting the number of monitored PFCs and their total concentration as a function of investigated species. Moreover, biomolecular effects on taxonomically different species are illustrated. In the final paragraph, main findings have been summarized and possible solutions to environmental threats posed by PFCs in the aquatic environment are discussed.

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Section: Solubility Persistence and Aquatic Half-life Of Pfcsmentioning

confidence: 99%

Section: Solubility Persistence and Aquatic Half-life Of Pfcsmentioning

confidence: 99%

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Savoca

Pace

2021

IJMS

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“…PFAS contamination of food may occur via irrigation and biosolid application in agriculture (Ghisi et al 2019) and home food production (Huset and Barry 2018) or farmed and hunted animals (Death et al 2021), resulting in additional human exposure. Ramakrishnan et al (2021) documented the presence of PFAS even within organic farming systems and produce production.…”

Section: Introductionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances Presence, Pathways, and Cycling through Drinking Water and Wastewater Treatment

et al. 2022

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“…Among them, perfluoroalkyl carboxylates (PFCAs) are a subset of PFAS compounds that do not undergo further degradation, hence they are often considered as the end-stage metabolites of the related precursor chemistries [2]. PFCAs are persistent due to chemical stability [3][4][5] and some of them can be detected in humans at low parts per billion levels [6][7][8]. Although the exact exposure routes have not been identified in the general population, dietary ingestion (food or water) has been suggested as the primary source of exposure to certain PFAS compounds [9].…”

Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP

Ruggiero

Miller

Idowu

et al. 2021

Livers

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Na+/taurocholate cotransporting polypeptide (NTCP) is important for the enterohepatic circulation of bile acids, which has been suggested to contribute to the long serum elimination half-lives of perfluoroalkyl substances in humans. We demonstrated that some perfluoroalkyl sulfonates are transported by NTCP; however, little was known about carboxylates. The purpose of this study was to determine if perfluoroalkyl carboxylates would interact with NTCP and potentially act as substrates. Sodium-dependent transport of [3H]-taurocholate was measured in human embryonic kidney cells (HEK293) stably expressing NTCP in the absence or presence of perfluoroalkyl carboxylates with varying chain lengths. PFCAs with 8 (PFOA), 9 (PFNA), and 10 (PFDA) carbons were the strongest inhibitors. Inhibition kinetics demonstrated competitive inhibition and indicated that PFNA was the strongest inhibitor followed by PFDA and PFOA. All three compounds are transported by NTCP, and kinetics experiments revealed that PFOA had the highest affinity for NTCP with a Km value of 1.8 ± 0.4 mM. The Km value PFNA was estimated to be 5.3 ± 3.5 mM and the value for PFDA could not be determined due to limited solubility. In conclusion, our results suggest that, in addition to sulfonates, perfluorinated carboxylates are substrates of NTCP and have the potential to interact with NTCP-mediated transport.

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Per- and polyfluoroalkyl substances (PFAS) in livestock and game species: A review

Cited by 126 publications

References 101 publications

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Per- and Polyfluoroalkyl Substances Presence, Pathways, and Cycling through Drinking Water and Wastewater Treatment

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP

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