Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis

Gao, Xu; Ni, Wanze; Zhu, Shuang; Wu, Yanxin; Y, Cui; Ma, Junrong; Liu, Yanhua; Qiao, Jinlong; Ye, Yan-Bin; Pan, Yang; Liu, Chaoqun; Zeng, Fangfang

doi:10.1016/j.envres.2021.111632

Cited by 77 publications

(54 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our opinion, several things should be considered before recommending SM/DBT. First, the lack of RCT designs is concerning, especially when considering Zeng et al's (2021) results were entirely attenuated when dropping non-paired studies, even though the sample size remained in the tens of thousands. So it's not a matter of lack of statistical power when limiting the metaanalysis only to paired designs.…”

Section: Bringing Home the Bacon And The Breastmilkmentioning

confidence: 99%

Current Resources for Evidence-Based Practice, January 2022

Bovbjerg¹,

Horan²

2022

Journal of Obstetric, Gynecologic & Neonatal Nursing

View full text Add to dashboard Cite

show abstract

Section: Bringing Home the Bacon And The Breastmilkmentioning

confidence: 99%

Current Resources for Evidence-Based Practice, January 2022

Bovbjerg¹,

Horan²

2022

Journal of Obstetric, Gynecologic & Neonatal Nursing

View full text Add to dashboard Cite

show abstract

“…Another study reported there was an inverse association between maternal blood lead levels and eGFR in overweight children at 8-12 years of age [67]. Epidemiological studies revealed that maternal exposure to polycyclic aromatic hydrocarbon, per-and polyfluoroalkyl substances, phthalates, polycyclic aromatic hydrocarbon, and PM 2.5 /PM 10 associated with preterm birth and LBW [68][69][70][71][72], are both risk factors related to a low nephron number.…”

Section: Environmental Chemicalsmentioning

confidence: 99%

The First Thousand Days: Kidney Health and Beyond

Hsu

Tain

2021

Healthcare

View full text Add to dashboard Cite

The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure to chemicals, substance abuse, medication use, infection, and exogenous stress. In the current review, we summarize environmental risk factors reported thus far in clinical and experimental studies relating to the programming of kidney disease, and systematize the knowledge on common mechanisms underlying renal programming. The aim of this review is to discuss the primary and secondary prevention actions for enhancing kidney health from pregnancy to age 2. The final task is to address the potential interventions to target renal programming through updating animal studies. Together, we can enhance the future of global kidney health in the first 1000 days of life.

show abstract

“…So far, there is lack of information about the BP and renal outcomes in children born to mothers exposed to PFOA, PFNA, or PAHs. However, maternal exposure to these chemicals have been linked to preterm birth, low birth weight (LBW), and intrauterine growth retardation (IUGR) (85)(86)(87). It is noteworthy that these risk factors related to reduced nephron number (70,71) as well as kidney disease and hypertension in later life (11,72,88,89).…”

Section: Epidemiological Evidencementioning

confidence: 99%

“…As we mentioned earlier, prior research has demonstrated that reduced nephron number, in relation to LBW and preterm birth, may result in hypertension and kidney disease in later life ( 11 , 72 , 88 , 89 ). Epidemiological studies demonstrated that maternal exposure to PFOA, PFNA, PAHs, phthalates, and PM 2.5 /PM 10 associated with preterm birth and LBW ( 76 , 85 – 87 , 90 ), both are risk factors related to reduced nephron number. Therefore, the role of these chemicals on nephron number in kidney disease and hypertension of developmental origins is still awaiting discovery but is certainly a subject of great interest.…”

Section: Prenatal Environmental Chemical Exposure On Renal Programmingmentioning

confidence: 99%

Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension

Hsu

Tain

2021

Front. Endocrinol.

View full text Add to dashboard Cite

Chronic kidney disease (CKD) and hypertension are becoming a global health challenge, despite developments in pharmacotherapy. Both diseases can begin in early life by so-called “developmental origins of health and disease” (DOHaD). Environmental chemical exposure during pregnancy can affect kidney development, resulting in renal programming. Here, we focus on environmental chemicals that pregnant mothers are likely to be exposed, including dioxins, bisphenol A (BPA), phthalates, per- and polyfluoroalkyl substances (PFAS), polycyclic aromatic hydrocarbons (PAH), heavy metals, and air pollution. We summarize current human evidence and animal models that supports the link between prenatal exposure to environmental chemicals and developmental origins of kidney disease and hypertension, with an emphasis on common mechanisms. These include oxidative stress, renin-angiotensin system, reduced nephron numbers, and aryl hydrocarbon receptor signaling pathway. Urgent action is required to identify toxic chemicals in the environment, avoid harmful chemicals exposure during pregnancy and lactation, and continue to discover other potentially harmful chemicals. Innovation is also needed to identify kidney disease and hypertension in the earliest stage, as well as translating effective reprogramming interventions from animal studies into clinical practice. Toward DOHaD approach, prohibiting toxic chemical exposure and better understanding of underlying mechanisms, we have the potential to reduce global burden of kidney disease and hypertension.

show abstract

Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis

Cited by 77 publications

References 55 publications

Current Resources for Evidence-Based Practice, January 2022

Current Resources for Evidence-Based Practice, January 2022

The First Thousand Days: Kidney Health and Beyond

Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension

Contact Info

Product

Resources

About