Per- and Polyfluoroalkyl (PFAS) Disruption of Thyroid Hormone Synthesis
Semiha Kevser Bali,
Rebecca Martin,
Nuno M. S. Almeida
et al.
Abstract:Per- and polyfluoroalkyl
substances (PFAS) are a group of environmental
pollutants that have been linked to a variety of health problems in
humans, including the disruption of thyroid functions. Herein, for
the first time, the impact of PFAS on thyroid hormone synthesis is
shown. Mid- to long-chain PFAS impact thyroid hormone synthesis by
changing the local hydrogen bond network as well as the required orientation
of hormonogenic residues, stopping the production of thyroxine (T4).
Furthermore, the toxic effec… Show more
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