Pequi oil (Caryocar brasilense Cambess.) nanoemulsion alters cell proliferation and damages key organelles in triple-negative breast cancer cells in vitro

Ombredane, Alicia Simalie; Silva, Lídia R A; Araújo, Victor Hugo Sousa; Costa, Patricia; Silva, Lucas C; Sampaio, Marina Carvalho; Lima, Milena C F; Veiga, Valdir Florêncio da; Vieira, Ivo José Curcino; Azevedo, Ricardo Bentes; Joanitti, Graziella Anselmo

doi:10.1016/j.biopha.2022.113348

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…In terms of scientific publications, several studies have addressed the content of bioactive compounds and their therapeutic potential, including both complementary approaches as well as conventional treatments. For example, a nanoemulsion of Pequi ( Caryocar brasilense Cambess ) oil has shown promising in vitro results as a complementary therapeutic approach to be employed along with conventional breast cancer treatment [ 101 ] ( Table 2 ). In vitro analysis also demonstrated the potential of ethanolic extract of pequi to promote oxidative protection in human coronary artery endothelial cells [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

“…PeNE showed a dose- and time-dependent cytotoxic effect with IC50 lower than free pequi oil after 48 h of exposure (p < 0.001). These promising results highlight the use of PeNE as a potential complementary therapeutic approach to be employed alongside conventional breast cancer treatments in the future [ 101 ] Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana The study evaluated the antiproliferative activity, antioxidant potential, and the chemical profile obtained from the whole fruit and leaves of Garcinia gardneriana. The content of carotenoids in the fruit and leaves were expressive.…”

Section: Resultsmentioning

confidence: 99%

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Exotic fruits patents trends: An overview based on technological prospection with a focus on Amazonian

Rodrigues,

Nunes,

Hodel

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exotic fruits patents trends: An overview based on technological prospection with a focus on Amazonian

Rodrigues,

Nunes,

Hodel

et al. 2023

Heliyon

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“…Nanodroplet characterization is considered a relevant prior step to ensure their suitability for in vitro and in vivo studies [ 27 ]. The obtained PeNE showed spherical or quasi-spherical morphologies with hydrodynamic diameters <200 nm, which is in the range expected for phosphatidylcholine-based nanoemulsions (150–300 nm) [ 28 ]. In addition, it was possible to obtain a nanoemulsion suspension with monodisperse nanodroplets (PDI < 0.260) [ 27 ] and negative zeta potential.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models

et al. 2022

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Pequi oil (Caryocar brasiliense) contains bioactive compounds capable of modulating the inflammatory process; however, its hydrophobic characteristic limits its therapeutic use. The encapsulation of pequi oil in nanoemulsions can improve its biodistribution and promote its immunomodulatory effects. Thus, the objective of the present study was to formulate pequi oil-based nanoemulsions (PeNE) to evaluate their biocompatibility, anti-inflammatory, and antinociceptive effects in in vitro (macrophages—J774.16) and in vivo (Rattus novergicus) models. PeNE were biocompatible, showed no cytotoxic and genotoxic effects and no changes in body weight, biochemistry, or histology of treated animals at all concentrations tested (90–360 µg/mL for 24 h, in vitro; 100–400 mg/kg p.o. 15 days, in vivo). It was possible to observe antinociceptive effects in a dose-dependent manner in the animals treated with PeNE, with a reduction of 27 and 40% in the doses of 100 and 400 mg/kg of PeNE, respectively (p < 0.05); however, the treatment with PeNE did not induce edema reduction in animals with carrageenan-induced edema. Thus, the promising results of this study point to the use of free and nanostructured pequi oil as a possible future approach to a preventive/therapeutic complementary treatment alongside existing conventional therapies for analgesia.

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“…Interestingly, nanoemulsion of Zingiber ottensii EO has been found to exhibit stronger anticancer properties against MCF-7 cells compared to free EO (Panyajai et al, 2022). Similarly, nanoemulsion containing EO from the Brazilian plant Caryocar brasiliense demonstrated enhanced cytotoxicity in 4T1 cells than EO alone (Ombredane et al, 2022). Han et al showed that β-elemene administered in nanoemulsion inhibited tumor metastasis to lung and liver and prolonged the survival of mice carrying 4T1 mouse TNBC tumor xenograft (Han et al, 2021).…”

Section: Eos In Nanoemulsionmentioning

confidence: 99%

Essential oils and their nanoformulations for breast cancer therapy

Thalappil,

Singh,

Carcereri de Prati

et al. 2023

Phytotherapy Research

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Breast Cancer (BC) is the most prevalent type of cancer in the world. Current treatments include surgery, radiation, and chemotherapy but often are associated with high toxicity to normal tissues, chemoresistance, and relapse. Thus, developing novel therapies which could combat these limitations is essential for effective treatment. In this context, phytochemicals are increasingly getting popular due to their safety profile, ability to efficiently target tumors, and circumvent limitations of existing treatments. Essential Oils (EOs) are mixtures of various phytochemicals which have shown potential anticancer activity in preclinical BC models. However, their clinical translation is limited by factors such as high volatility, low stability, and poor solubility. Nanotechnology has facilitated their encapsulation in a variety of nanostructures and proven to overcome these limitations. In this review, we have efficiently summarized the current knowledge on the anticancer effect of EOs and constituents in both in in vitro and in in vivo BC models. Further, we also provide a descriptive account on the potential of nanotechnology in enhancing the anti‐BC activity of EOs and their constituents. The papers discussed in this review were selected using the keywords “antiproliferative Essential Oils in breast cancer,” “anticancer activity of Essential Oil in breast cancer,” and “cytotoxicity of Essential Oils in breast cancer” performed in PubMed and ScienceDirect databases.

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Pequi oil (Caryocar brasilense Cambess.) nanoemulsion alters cell proliferation and damages key organelles in triple-negative breast cancer cells in vitro

Cited by 6 publications

References 38 publications

Exotic fruits patents trends: An overview based on technological prospection with a focus on Amazonian

Exotic fruits patents trends: An overview based on technological prospection with a focus on Amazonian

Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models

Essential oils and their nanoformulations for breast cancer therapy

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