Peptoids for biomaterials science

Lau, King Hang Aaron

doi:10.1039/c3bm60269a

Cited by 70 publications

(60 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, peptidebased SAMs, 217,218 peptoid-based SAMs 219 and peptoid-based polymer brushes 36,[220][221][222][223][224][225] have recently been found to be highly effective as antifouling macroscopic surface coatings. Indeed, peptidebased SAMs, 217,218 peptoid-based SAMs 219 and peptoid-based polymer brushes 36,[220][221][222][223][224][225] have recently been found to be highly effective as antifouling macroscopic surface coatings.…”

Section: Peptides and Peptoidsmentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

View full text Add to dashboard Cite

Nonspecific protein adsorption and/or microbial adsorption on biomedical materials adversely affects the efficacy of a range of biomedical systems, from implants and biosensors to nanoparticles. To address this problem, antibiofouling polymers can be coated on biomedical devices or built into nanoparticles to confer protein and/or microbial repellent properties. The current review provides an overview of the range of synthetic polymers currently used to this end and explores their biomedical potential. The most widely-used antifouling polymer, poly(ethylene glycol) (PEG) is reviewed alongside several promising alternatives, including zwitterionic polymers, poly(hydroxyfunctional acrylates), poly(2-oxazoline)s, poly (vinylpyrrolidone), poly(glycerol), peptides and peptoids. For each material, notable applications for both nanomedicine and macroscopic surface coatings are highlighted.

show abstract

Section: Peptides and Peptoidsmentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

View full text Add to dashboard Cite

show abstract

“…Peptoids are a highly designable, 26 biologically active, 27,28 and efficiently synthesized 29,30 class of bioinspired polymer, with N-substituted side chains appended from a glycine backbone. [31][32][33][34][35][36][37][38] Relative to C α --5-substituted peptides, N-substitution in peptoids eliminates backbone chirality and backbone hydrogen bonding, facilitating extended planar configurations stabilized by multiple weak interactions. 24,39,40 At the air-water interface, peptoids containing an alternating sequence of polar and non-polar monomers organize into a monolayer via adsorption from solution.…”

mentioning

confidence: 99%

Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets

et al. 2014

View full text Add to dashboard Cite

Organic two-dimensional nanomaterials are of growing importance, yet few general synthetic methods exist to produce them in high yields and to precisely functionalize them. We previously developed an efficient hierarchical supramolecular assembly route to peptoid bilayer nanosheets, where the organization of biomimetic polymer sequences is catalyzed by an air-water interface. Here we determine at which stages of assembly the nanoscale and atomic-scale order appear. We used X-ray scattering, grazing incidence X-ray scattering at the air-water interface, electron diffraction, and a recently developed computational coarse-grained peptoid model to probe the molecular ordering at various stages of assembly. We found that lateral packing and organization of the chains occurs during the formation of a peptoid monolayer, prior to its collapse into a bilayer. Identifying the structure-determining step enables strategies to influence nanosheet order, to predict and optimize production yields, and to further engineer this class of material. More generally, our results provide a guide for using fluid interfaces to catalytically assemble 2D nanomaterials.

show abstract

“…83 Peptoids can also be easily generated to be compatible with various biotic and abiotic enviroments, 83,87 and a wide range of solvents. 15,83 Thus, peptoids represent a unique opportunity for functionalizing and assembly of inorganic NPs towards a variety of applications.…”

Section: N-substituted Glycine Oligomers -Peptoids -As Mediatorsmentioning

confidence: 99%

Aggregation of inorganic nanoparticles mediated by biomimetic oligomers

Tigger-Zaborov

Maayan

2015

Org. Biomol. Chem.

View full text Add to dashboard Cite

Assemblies of nanoparticles (NPs) have been broadly used for the construction of materials with unique spectroscopic and chiral properties for applications in various scientific disciplines such as sensing, bio-nanotechnology and medicine. Mediating the aggregation of NPs by synthetic biomimetic oligomers, namely, DNA, PNA, peptides and peptide mimics, rather than by small organic molecules has been shown to produce interesting supramolecular structures and enable the combination of the biocompatibility of the mediators and the spectroscopic properties of the NPs. Yet, the key to using this powerful approach for designing new functional materials is to understand the NPs aggregation patterns induced by biopolymers and biomimetic oligomers. Herein we describe the important developments in this field, from early studies to recent work with an emphasis on synthetic methods and tools for controlled assembly of metal NPs by biomimetic polymers and oligomers.

show abstract

Peptoids for biomaterials science

Cited by 70 publications

References 83 publications

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets

Aggregation of inorganic nanoparticles mediated by biomimetic oligomers

Contact Info

Product

Resources

About