Peptidomics for discovery, bioavailability and monitoring of dairy bioactive peptides

Sánchez-Rivera, Laura; Martínez-Maqueda, Daniel; Cruz-Huerta, Elvia; Miralles, Beatriz; Recio, Isidra

doi:10.1016/j.foodres.2014.01.069

Cited by 126 publications

(97 citation statements)

References 135 publications

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“…The HRE values in the three REE-Fe groups were significantly higher (p < 0.05) than that in the blank group, and the high-dose group had the highest HRE value. The results showed that the REE-Fe had better bioavailability than FeSO 4 or Fe-Gly, which indicates the tripeptide can promote the absorption of iron [31].…”

Section: Hb Hct and Hre Levels Of Ratsmentioning

confidence: 94%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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Section: Hb Hct and Hre Levels Of Ratsmentioning

confidence: 94%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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“…[5][6][7] However, advances in mass spectrometric (MS) analysis have allowed greater capability in the identication of peptides within complex mixtures and also identication of a large number of peptide sequences in an automated manner, for reviews, see: ref. [8][9][10][11]. Nevertheless, challenges such as the reliable identication of short peptide sequences (<5 amino acid residues) are still an issue for a more comprehensive understanding of dietary BAP structures.…”

Section: Richard (Dick) J Fitzgerald Is a Professor In The Life Sciementioning

confidence: 99%

Learnings from quantitative structure–activity relationship (QSAR) studies with respect to food protein-derived bioactive peptides: a review

Nongonierma

Fitzgerald

2016

RSC Adv.

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“…Processing techniques in laboratory and on industrial scale are now being developed for the extraction, fractionation and isolation of main proteins from milk [54][55][56][57], with particular attention to modern non-thermal, clean and green methodologies [58]. It is worth stressing, as already demonstrated by several studies, that each time a nutraceutical with potential health benefits is needed for a functional food, a specific enzymatic hydrolysis of milk proteins should be planned [59,60].…”

Section: Methodology Toward Innovative Aspectsmentioning

confidence: 99%

Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

Lucarini¹

2017

Beverages

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Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.Keywords: bioactive peptides; milk; nutraceuticals; bioavailability; biorefinery Bioactive Components of Milk: Focus on BPsMilk provides a wide range of biologically active compounds that protect humans against diseases and pathogens such as immunoglobulins, antimicrobial proteins and peptides, oligosaccharides, lipids, as well as many other components at low concentrations with significant potential health benefits [1] (Figure 1). Among these compounds, proteins play a key role as nutrients and as promoters of the physiological function and health role as source of Bioactive Peptides (BPs) [ Abstract: Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.

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Peptidomics for discovery, bioavailability and monitoring of dairy bioactive peptides

Cited by 126 publications

References 135 publications

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Learnings from quantitative structure–activity relationship (QSAR) studies with respect to food protein-derived bioactive peptides: a review

Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

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