Abstract:Sepsis constitutes a major cause of death in intensive care units. Patients present a dysregulated response to infection, which progresses through different pro/anti-inflammatory phases. The lack of tools to monitor their response constrains the therapeutic approaches. Here, we evaluated a test based on plasma protein fingerprints acquired by MALDI-TOF-mass spectrometry and supervised/unsupervised algorithms to discriminate the different immunological stages of sepsis in lipopolysaccharide-induced murine model… Show more
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