Peptides

Döhren, Hans von

doi:10.1002/9780470054581.eib474

Cited by 2 publications

(3 citation statements)

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“…Bacteriocins are antimicrobial compounds that inhibit or inactivate microorganisms that are usually, but not always, closely related to the producer strain (Cleveland et al, 2001). In recent decades, a great interest has been shown in the bacteriocins as natural preservatives, and they have been extensively studied, especially those produced by LAB (lactic acid bacteria) because of their potential applications as food additives in dairy and meat products (Sobrino‐Lopez and Martin‐Belloso, 2008). Antimicrobial peptides have received increasing attention because of their efficiency for the biological control of spoilage and pathogenic organisms, and they present potential applications in food (O'Sullivan et al, 2002; Deegan et al, 2006) and clinical (Fontana et al, 2006; Oh et al, 2006) fields.…”

Section: Introductionmentioning

confidence: 99%

“…The genus Bacillus includes a number of bacteriocinogenic species including Bacillus subtilis, Bacillus cereus, Bacillus thuringiensis and Bacillus coagulans, among others (Cherif et al, 2001;Bizani and Brandelli, 2002). Bacillus species produce a large number of antimicrobial peptides representing several different basic chemical structures (von Dö hren, 1995). Bacteriocins or BLS (bacteriocin-like substances) from the genus Bacillus have been characterized, such as thuricin 7 (Cherif et al, 2001), thuricin 439A and thuricin 439B (Ahern et al, 2003), cerein 7A and 7B (Oscá riz et al, 2007), cerein 8A (Bizani et al, 2005) and subtilosin A (Kawulka et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the in vitro cytotoxicity of the antimicrobial peptide P34

Vaucher

Motta

Brandelli

2010

Cell Biology International

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The in vitro cytotoxicity of the antimicrobial peptide P34 was evaluated in different eukaryotic cells. The food-grade bacteriocin nisin was also analysed for comparison. Vero cells were treated with different concentrations (0.02-2.5 microg x ml(-1)) of antimicrobial peptide P34 and nisin. Cell viability and plasma membrane integrity were checked by MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide], NRU (Neutral Red dye uptake) and LDH (lactate dehydrogenase) assays. The EC50 values of the peptide P34 in MTT and NRU assays were 0.60 and 1.25 microg x ml(-1) respectively, while values of nisin found were 0.50 and 1.04 microg x ml(-1). In the LDH assay, the EC50 values were 0.65 and 0.62 microg x ml(-1) for P34 and nisin, respectively. The peptide P34 revealed similar haemolytic activity on human erythrocytes (5.8%) when compared with nisin (4.9%). The effects on viability, motility and acrosomal exocytosis of human sperm were also evaluated. Nisin and P34 showed similar effects on sperm parameters. The evaluation of cytotoxicity of antimicrobial peptides is a critical step to guarantee their safe use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the in vitro cytotoxicity of the antimicrobial peptide P34

Vaucher

Motta

Brandelli

2010

Cell Biology International

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“…The inter-rater reliability was 0.73 (range 0.67–1.00) [ 27 ]. Seventeen potentially relevant conference abstracts were identified, and authors were contacted for further details to enable assessment of eligibility, of which eight responded with additional information [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Nine remain unclassified (see Supplementary S2 , for papers awaiting classification).…”

Section: Resultsmentioning

confidence: 99%

Social Isolation and Social Support Influence Health Service Utilisation and Survival after a Cardiovascular Disease Event: A Systematic Review

Freak‐Poli

Phyo

et al. 2023

IJERPH

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Both cardiovascular disease (CVD) and social health carry high health and economic burdens. We undertook a systematic review to investigate the association between social isolation, low social support, and loneliness with health service utilisation and survival after a CVD event among people living in Australia and New Zealand. Four electronic databases were systematically searched for the period before June 2020. Two reviewers undertook the title/abstract screen. One reviewer undertook a full-text screen and data extraction. A second author checked data extraction. Of 756 records, 25 papers met our inclusion criteria. Included studies recruited 10–12,821 participants, aged 18–98 years, and the majority were males. Greater social support was consistently associated with better outcomes on four of the five themes (discharge destination, outpatient rehabilitation attendance, rehospitalisation and survival outcomes; no papers assessed the length of inpatient stay). Positive social health was consistently associated with better discharge designation to higher independent living. As partner status and living status did not align with social isolation and social support findings in this review, we recommend they not be used as social health proxies. Our systematic review demonstrates that social health is considered in cardiac care decisions and plays a role in how healthcare is being delivered (i.e., outpatient, rehabilitation, or nursing home). This likely contributes to our finding that lower social support is associated with high-intensity healthcare services, lower outpatient rehabilitation attendance, greater rehospitalisation and poorer survival. Given our evidence, the first step to improve cardiac outcomes is acknowledging that social health is part of the decision-making process. Incorporating a formal assessment of social support into healthcare management plans will likely improve cardiac outcomes and survival. Further research is required to assess if support person/s need to engage in the risk reduction behaviours themselves for outpatient rehabilitation to be effective. Further synthesis of the impact of social isolation and loneliness on health service utilisation and survival after a CVD event is required.

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Peptides

Cited by 2 publications

References 148 publications

Evaluation of the in vitro cytotoxicity of the antimicrobial peptide P34

Evaluation of the in vitro cytotoxicity of the antimicrobial peptide P34

Social Isolation and Social Support Influence Health Service Utilisation and Survival after a Cardiovascular Disease Event: A Systematic Review

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