Peptides for Health Benefits 2019

Martínez‐Villaluenga, Cristina; Hernández-Ledesma, Blanca

doi:10.3390/ijms21072543

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…Proteins have high-fat content in animals and can cause diseases such as hypertension and cardiac disease if consumed in large quantities. Plant proteins, on the other hand, have no associated fat and no side effects [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Biologically Synthesized Peptides Show Remarkable Inhibition Activity against Angiotensin‐Converting Enzyme: A Promising Approach for Peptide Development against Autoimmune Diseases

Mujtaba

Jahan

Jamal

et al. 2022

BioMed Research International

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Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role in immune functions. ACE is elevated in immune cells in inflammatory diseases including atherosclerosis, granuloma, chronic kidney disease, and also autoimmune diseases, like multiple sclerosis, rheumatoid arthritis, and type I diabetes. No significant information prevails in the literature regarding the isolation, identification, and profiling of potential ACE inhibitory peptides. In the present study, indigenous crop varieties like seeds (peanut, corn, oat, sunflower, chickpea, parsley, cottonseed, papaya, sesame, and flaxseed) were used to evaluate their ACE inhibition activity. Variables including hydrolysis time, enzyme-to-substrate ratio (E/S), pH, and temperature were standardized to acquire the most suitable and optimum ACE inhibition activity. Seeds of cotton, chickpea, and peanuts displayed remarkably maximum ACE inhibition activity than other plants. The study disclosed that maximum ACE inhibitory activity (86%) was evaluated from cottonseed at pH 8.0, temperature of 45°C, hydrolysis time of 2 hrs, and enzyme to the substrate (E/S) ratio of 1 : 5 followed by peanuts (76%) and chickpea (55%). SDS-PAGE confirmed that vicilin protein is present in cottonseed and peanut seed while cruciferin and napin proteins are present in chickpeas. LC-MS/MS analysis disclosed potential novel peptides in hydrolyzed cottonseed that can be ascribed as potential ACE inhibitors which have never been reported and studied earlier. The current study further showed that cottonseed peptides due to their promising ACE inhibitory activity can be a valuable source in the field of ACE inhibitor development.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Biologically Synthesized Peptides Show Remarkable Inhibition Activity against Angiotensin‐Converting Enzyme: A Promising Approach for Peptide Development against Autoimmune Diseases

Mujtaba

Jahan

Jamal

et al. 2022

BioMed Research International

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show abstract

“…These foods not only contain basic nutrients but are also rich in probiotics, antioxidants, polyphenols, bioactive compounds, and beneficial fatty acids and are known as functional foods. Their promising therapies and regulatory functions with active compounds may become a powerful tool against synthetic drugs [ 15 ], but a lot of studies are still needed to understand their roles. Hence, promoting healthy dietary intake has become a central part of the world health organization’s plan of action to prevent and monitor NCDs [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Food-Derived Opioid Peptides in Human Health: A Review

Tyagi

Daliri

Ofosu

et al. 2020

IJMS

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World Health Organization data suggest that stress, depression, and anxiety have a noticeable prevalence and are becoming some of the most common causes of disability in the Western world. Stress-related disorders are considered to be a challenge for the healthcare system with their great economic and social impact. The knowledge on these conditions is not very clear among many people, as a high proportion of patients do not respond to the currently available medications for targeting the monoaminergic system. In addition, the use of clinical drugs is also associated with various side effects such as vomiting, dizziness, sedation, nausea, constipation, and many more, which prevents their effective use. Therefore, opioid peptides derived from food sources are becoming one of the safe and natural alternatives because of their production from natural sources such as animals and plant proteins. The requirement for screening and considering dietary proteins as a source of bioactive peptides is highlighted to understand their potential roles in stress-related disorders as a part of a diet or as a drug complementing therapeutic prescription. In this review, we discussed current knowledge on opioid endogenous and exogenous peptides concentrating on their production, purification, and related studies. To fully understand their potential in stress-related conditions, either as a drug or as a therapeutic part of a diet prescription, the need to screen more dietary proteins as a source of novel opioid peptides is emphasized.

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“…Peptides have been receiving great attention for their ability to establish specific and high-affinity interactions with endogenous receptors ( Martinez-Villaluenga and Hernandez-Ledesma, 2020 ). In fact, bioactive peptides can act as hormones, neurotransmitters, and antimicrobial agents in vivo , with reported beneficial effects on blood pressure and lipid metabolism as well as anticancer, immunomodulatory, analgesic, antioxidant and anti-inflammatory activity ( Tinoco and Saghatelian, 2011 ; Cicero et al, 2017 ).…”

Section: Aquaglyceroporin Modulators With Pharmacological Actionmentioning

confidence: 99%

Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases

Pimpão

Wragg

Casini

et al. 2022

Front. Mol. Biosci.

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Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol and other small uncharged solutes across cell membranes, have been recognized for their important role in human physiology and their involvement in multiple disorders, mostly related to disturbed energy homeostasis. Aquaglyceroporins dysfunction in a variety of pathological conditions highlighted their targeting as novel therapeutic strategies, boosting the search for potent and selective modulators with pharmacological properties. The identification of selective inhibitors with potential clinical applications has been challenging, relying on accurate assays to measure membrane glycerol permeability and validate effective functional blockers. Additionally, biologicals such as hormones and natural compounds have been revealed as alternative strategies to modulate aquaglyceroporins via their gene and protein expression. This review summarizes the current knowledge of aquaglyceroporins’ involvement in several pathologies and the experimental approaches used to evaluate glycerol permeability and aquaglyceroporin modulation. In addition, we provide an update on aquaglyceroporins modulators reported to impact disease, unveiling aquaglyceroporin pharmacological targeting as a promising approach for innovative therapeutics.

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Peptides for Health Benefits 2019

Abstract: In recent years, peptides have received increased interest in pharmaceutical, food, cosmetics and various other fields [...]

Cited by 17 publications

References 36 publications

[Retracted] Biologically Synthesized Peptides Show Remarkable Inhibition Activity against Angiotensin‐Converting Enzyme: A Promising Approach for Peptide Development against Autoimmune Diseases

[Retracted] Biologically Synthesized Peptides Show Remarkable Inhibition Activity against Angiotensin‐Converting Enzyme: A Promising Approach for Peptide Development against Autoimmune Diseases

Food-Derived Opioid Peptides in Human Health: A Review

Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases

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