Peptides for biopharmaceutical applications

Agyei, Dominic; Tan, Kei Xian; Pan, Sharadwata; Udenigwe, Chibuike C.; Danquah, Michael K.

doi:10.1016/b978-0-08-100736-5.00009-0

Cited by 13 publications

(12 citation statements)

References 88 publications

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“…The challenge of overcoming the limitations of peptides has driven the scientific community to search for solutions, such as peptide engineering via amino acid substitution, peptide conjugation, new formulations, and alternative delivery strategies [ 10 ]. Peptide engineering is based on the replacement of amino acids with d -amino acids to improve stability and half-life, to which N-acetylation and C-amidation are applied [ 22 ].…”

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

“…Daptomycin is one of these lipopeptides, which is produced from natural lipidation and is widely used to treat diseases caused by Gram-positive bacteria. Another example of natural lipidation is surfactin, which exhibits antimicrobial, antiviral, and antitumor activities [ 22 , 25 ]. Some of the peptides on the market that have gone through synthetic lipidation are liraglutide (Victoza ® ) and insulin detemir (Levemir ® ) [ 24 ].…”

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

“…Cycling, N-methylation, and lactamic bridges have improved the permeability, stability, potency, and solubility of peptides [ 22 ]. An alternative use of peptides to improve its potency and selectivity is the synergy of peptides with each other and with other conventional drugs.…”

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

“…New formulation strategies to protect peptides from degradation include the addition of protease inhibitors. The incorporation of salt, sugar, and heparin in the formulations improves bioavailability, solubility, and stability in vivo [ 22 ]. Another type of formulation is hydrogels.…”

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

“… Peptide limitations and how to overcome them. [ 10 , 22 , 23 , 26 , 27 ]. On the left side there are four limitations to working with peptides which are in red.…”

Section: Figurementioning

confidence: 99%

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Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides

2020

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Peptides are naturally produced by all organisms and exhibit a wide range of physiological, immunomodulatory, and wound healing functions. Furthermore, they can provide with protection against microorganisms and tumor cells. Their multifaceted performance, high selectivity, and reduced toxicity have positioned them as effective therapeutic agents, representing a positive economic impact for pharmaceutical companies. Currently, efforts have been made to invest in the development of new peptides with antimicrobial and anticancer properties, but the poor stability of these molecules in physiological environments has triggered a bottleneck. Therefore, some tools, such as nanotechnology and in silico approaches can be applied as alternatives to try to overcome these obstacles. In silico studies provide a priori knowledge that can lead to the development of new anticancer peptides with enhanced biological activity and improved stability. This review focuses on the current status of research in peptides with dual antimicrobial–anticancer activity, including advances in computational biology using in silico analyses as a powerful tool for the study and rational design of these types of peptides.

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Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

Section: Efforts To Overcome Peptide Limitationsmentioning

confidence: 99%

“… Peptide limitations and how to overcome them. [ 10 , 22 , 23 , 26 , 27 ]. On the left side there are four limitations to working with peptides which are in red.…”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations