Peptides Derived from the Extracellular Loops of Receptors: Structure, Mechanism of Action, Use in Physiology and Medicine

Ao, Shpakov

doi:10.1007/s11055-012-9700-1

Cited by 3 publications

(3 citation statements)

References 73 publications

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“…Their action being receptor and site specific, they can induce either inhibition or enhancement of signal transduction via the cognate receptor. This is in good agreement with the results obtained with synthetic peptides derived from the extracellular and intracellular regions of different GPCRs [61, 62]. Thus, peptides corresponding to the extracellular loops of MCRs are a promising tool in the study of etiology of DM and its cerebral complications and give a perspective approach to develop new models of DM and obesity based on antibody-induced deregulation of the brain AC signaling.…”

Section: Camp Signaling In the Brainsupporting

confidence: 87%

The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus

Шпаков

Derkach

2013

Journal of Signal Transduction

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Diabetes mellitus (DM) induces a large number of diseases of the nervous, cardiovascular, and some other systems of the organism. One of the main causes of the diseases is the changes in the functional activity of hormonal signaling systems which lead to the alterations and abnormalities of the cellular processes and contribute to triggering and developing many DM complications. The key role in the control of physiological and biochemical processes belongs to the adenylyl cyclase (AC) signaling system, sensitive to biogenic amines and polypeptide hormones. The review is devoted to the changes in the GPCR-G protein-AC system in the brain, heart, skeletal muscles, liver, and the adipose tissue in experimental and human DM of the types 1 and 2 and also to the role of the changes in AC signaling in the pathogenesis and etiology of DM and its complications. It is shown that the changes of the functional state of hormone-sensitive AC system are dependent to a large extent on the type and duration of DM and in experimental DM on the model of the disease. The degree of alterations and abnormalities of AC signaling pathways correlates very well with the severity of DM and its complications.

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Section: Camp Signaling In the Brainsupporting

confidence: 87%

The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus

Шпаков

Derkach

2013

Journal of Signal Transduction

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“…In addition to the main participants of the process of hemostasis regulation, such as blood cells and blood clotting factors, the most interesting are physiologically active peptides, which have been isolated from almost all internal organs. They have the ability to regulate the functional and proliferative activity of tissue cells, which are the starting material for their production (7,8). Our work focuses on the study of the functioning of polypeptides isolated from the spleen (conventionally designated as peptide-1) and erythrocytes (respectively peptide-2) in radiation damage of the organism.…”

Section: Introductionmentioning

confidence: 99%

Influence of Peptide Bioregulators on Indicators of Hemostasis in Blood of Irradiated Experimental Animals at Low Altitude Conditions

KURMANBEKOVA,

BEİSHENALİEVA,

OMURZAKOVA

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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In modern biology and medicine, much attention is paid to the study of the hemostasis regulation of some cell populations by substances of a peptide nature. They have the ability to regulate the functional and proliferative activity of cells and ensure communication in normal and pathological conditions. Research data showed that significant violations of the hemostatic system also occur with radiation damage to the body. One of the first radiation responses involves the coagulation cascade's activation, which leads to the breakdown of fibrinogen and the formation of fibrin clots. The potential threat of this is quite evident due to the existence of uranium mining tailings in several regions of the Kyrgyz Republic. Considering that significant disturbances of the hemostatic system occur during radiation damage to the body, and effective means are clearly not enough, the study of the effect of bioregulatory peptides in these conditions is of great importance. In the study, we carried out the total X-ray irradiation of laboratory animals on the X-ray therapeutic apparatus RUM-17. Peptide bioregulators peptide-1 and peptide-2 were administered intramuscularly to irradiated animals. Throughout the research, we used methods characterizing all links of hemostasis: vascular-platelet hemostasis, coagulation hemostasis, and fibrinolysis. The study has shown that the use of the peptide bioregulators in the background of acute radiation pathology leads to a decrease in the intensity of the chronic course of post-radiation thrombo hemorrhagic syndrome, contributing to an increase in the content of antithrombin III in the blood and modulating the versatile effects of endogenous heparin, which undoubtedly have a beneficial effect on the pathogenesis of radiation sickness.

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“…Physiologically active peptides were isolated virtually from all the inner organs, they have the ability of regulation of functional and proliferative activity of cells in the tissues, which are the initial material for their obtaining. Therefore the studying of their biological activity is deemed actual and important (Ivanov, 2010;Shpakov, 2013).…”

Section: Introductionmentioning

confidence: 99%

Biological influence of extracts of cryopreserved fragments of piglets’ heart and skin

Rohoza

Bespalova

Chizh

et al. 2017

Preprint

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One of the new directions on which the searches used to find the methods to effectively correct the regeneration in case of different pathologies is the application of biologically active peptides and their mixtures. In the work there was investigated the biological influence of extracts of cryopreserved fragments of skin and heart of newborn piglets with the cold wound of skin and myocardial ischemia in rats respectively. For investigations the extracts were obtained from cryopreserved fragments of newborn piglets’ skin and heart. Cold wound of skin was modelled in rats by 10 mm copper applicator cooled in liquid nitrogen down to -196°C; the areas of wounds were determined by planimetric method, the white blood cells’ counts were analysed. In rats with myocardial ischemia there were studied the electrocardiograms, heart rate variability and proliferative activity of heart cells. The injection of extracts of cryopreserved fragments of skin to the animal’s abdominal cavity accelerates the healing of cold wound of skin and normalizes the response of immune system to an injury. After the injection during 2 months to the animals with myocardial ischemia with extracts of cryopreserved fragments of heart the normalization of electrophysiological indices of heart activity was observed that testified about the improved blood supply to a heart muscle. Being injected to healthy animals and those with myocardial ischemia the extracts of cryopreserved fragments of heart resulted in an increase in proliferative activity of heart cells. The studied extracts have a high biological effect and can be applied when designing the drugs for regenerative medicine.Summary statementThe extracts of cryopreserved fragments of piglets’ heart or skin were shown as stimulating reparative regeneration of heart tissues in myocardial ischemia of rats and skin in a cold wound, respectively.

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Peptides Derived from the Extracellular Loops of Receptors: Structure, Mechanism of Action, Use in Physiology and Medicine

Cited by 3 publications

References 73 publications

The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus

The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus

Influence of Peptide Bioregulators on Indicators of Hemostasis in Blood of Irradiated Experimental Animals at Low Altitude Conditions

Biological influence of extracts of cryopreserved fragments of piglets’ heart and skin

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