Peptides Derived from Exon v6 of the CD44 Extracellular Domain Prevent Activation of Receptor Tyrosine Kinase and Subsequently Angiogenesis and Metastatic Spread of Tumor Cells

c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 inCd44null mice

“…Peptides comprising these amino acids, the smallest being 5-mers, completely inhibit the activation of the c-Met receptor (Matzke et al , 2005) and the metastatic spread of several cancer cell lines (Ponta and Orian-Rousseau, 2009). …”

“…The coreceptor function of CD44v6 for c-Met relies on three amino acids in exon v6—EWQ in rat, GWQ in mouse, and RWH in human—which are strictly required for c-Met activation. Peptides comprising these amino acids, the smallest being 5-mers, completely inhibit the activation of the c-Met receptor ( Matzke et al , 2005 ) and the metastatic spread of several cancer cell lines ( Ponta and Orian-Rousseau, 2009 ).…”