Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses

Application of Surface-Linked Liposomal Antigens to the Development of Vaccines That Induce Both Humoral and Cellular Immunity

“…The efficacy of a CTL-based influenza vaccine was first evaluated in a C57BL/6 mouse model with an H-2 b -restricted CTL epitope, NP 366-374 , which was derived from nucleoprotein (NP) of H3N2 influenza virus (33). The liposome-coupled peptide NP 366-374 induced antigen-specific CTLs and successfully suppressed replication of H3N2 influenza virus in the lungs of the C57BL/6 mice.…”

Highly Efficient Antiviral CD8+T-Cell Induction by Peptides Coupled to the Surfaces of Liposomes

“…Ag chemically coupled to the surfaces of liposomes composed of unsaturated fatty acids has been shown to be presented to CD8 ϩ T cells (42) and to induce protective immunity against influenza virus (27). For further evaluation of the use of surface-linked liposomal peptide as an antiviral vaccine, we chose an immunodominant CTL epitope, GP33-41, of LCMV, which is presented by the H-2D b molecule (10,16,36).…”

“…Furthermore, the cross-presentation of OVA coupled to liposomes consisting of unsaturated fatty acids was further confirmed by the in vivo induction of cytotoxic T lymphocytes (CTLs) which conferred tumor eradication (42) and protection against influenza virus (27) in mice. However, the advantages of the surface-linked liposomal peptides for other forms of vaccines, especially regarding the efficiency of effector CD8 ϩ T cells and the inducibility of long-term memory CD8 ϩ T cells, have not been demonstrated.…”

Development of New Vaccine－New Method to Prepare Artificial Membrane Vaccine using Inter-Membrane Protein Transfer

“…Surface-linked liposomal peptide has been shown to serves as an effective vaccine without showing detrimental effects in the presence of immune potentiators [23,24]. Furthermore, influenza virosomes enhanced CTL (cytotoxic T lymphocyte) induction [25][26][27].…”