Peptides and Proteins

Balandrán‐Quintana, René Renato; Mendoza–Wilson, Ana María; Montfort, Gabriela Ramos-Clamont; Huerta‐Ocampo, José Ángel; Mazorra-Manzano, Miguel A.

doi:10.1007/978-3-030-57469-7_3

Cited by 2 publications

(1 citation statement)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These peptides are produced through the proteolytic cleavage of precisely sequenced amino acid chains. They are characterized by short peptide chains of two to twenty amino acids and a molar mass below 6000 Da [50,51]. This step of the food processing process is catalyzed by both endogenous and exogenous enzymes derived from plant, animal, and microbiological sources.…”

Section: Peptide Productionmentioning

confidence: 99%

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Santos,

Silva,

Grácio

et al. 2024

IJMS

View full text Add to dashboard Cite

Milk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic viral diseases. While several publications focus on milk’s bioactivities, antiviral peptides remain largely neglected in reviews. This knowledge is critical for identifying novel research directions and analyzing potential nutraceuticals within the One Health context. Our review aims to gather the existing scientific information on milk-derived antiviral proteins and peptides against several zoonotic viral diseases, and their possible mechanisms. Overall, in-depth research has increasingly revealed them as a promising and novel strategy against viruses, principally for those constituting a plausible pandemic threat. The underlying mechanisms of the bioactivity of milk’s proteins include inhibiting viral entry and attachment to the host cells, blocking replication, or even viral inactivation via peptide–membrane interactions. Their marked versatility and effectiveness stand out compared to other antiviral peptides and can support future research and development in the post-COVID-19 era. Overall, our review helps to emphasize the importance of potentially effective milk-derived peptides, and their significance for veterinary and human medicines, along with the pharmaceutical, nutraceutical, and dairy industry.

show abstract

Section: Peptide Productionmentioning

confidence: 99%

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Santos,

Silva,

Grácio

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Dairy Milk Protein–Derived Bioactive Peptides: Avengers Against Metabolic Syndrome

Koirala,

Dahal,

Rai

et al. 2023

Curr Nutr Rep

View full text Add to dashboard Cite

Purpose of Review Metabolic syndrome is continuously increasing among the world’s populations. Metabolic syndrome is a medical condition in which individuals suffer from high blood pressure, high blood glucose levels, and obesity. The in vitro and in vivo bioactivities of dairy milk protein–derived peptides (MPDP) have proven their potential as an excellent natural alternative to the current medical treatment for metabolic syndrome. In this context, the review discussed the major protein source of dairy milk and provides current knowledge on the novel and integrated approach to MPDP production. A detailed comprehensive discussion is provided on the current state of knowledge regarding the in vitro and in vivo bioactivities of MPDP against metabolic syndrome. In addition, the most important aspect of digestive stability, allergenicity, and further directions for MPDP application is provided. Recent Findings The major proteins found in milk are casein and whey, while a minor portion of serum albumin and transferrin are reported. Upon gastrointestinal digestion or enzymatic hydrolysis, these proteins produce peptides with various biological activities including antioxidative, antiinflammatory, antihypertensive, antidiabetic, and antihypercholesterolemic, which could help in ameliorating metabolic syndrome. Summary Bioactive MPDP has the potential to curtail metabolic syndrome and potentially act as a safe replacement for chemical drugs with fewer side effects. Supplementary Information The online version contains supplementary material available at 10.1007/s13668-023-00472-1.

show abstract

Peptides and Proteins

Cited by 2 publications

References 192 publications

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Dairy Milk Protein–Derived Bioactive Peptides: Avengers Against Metabolic Syndrome

Contact Info

Product

Resources

About