Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre.

Evans, Peter; Reale, Vincenzina; Villegas, Jorge

doi:10.1113/jphysiol.1986.sp016241

Cited by 37 publications

(27 citation statements)

References 47 publications

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“…Previous studies on the interaction between the squid giant axon and its associated Schwann cells have shown a sequence of activation involving transmitters, neuromodulators, and second messengers (Evans et al, 1986;Villegas, 1984). The present report adds further complexity to the story.…”

Section: Discussionmentioning

confidence: 63%

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

Lieberman¹,

Abbott²,

Hassan³

1989

Glia

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High-frequency stimulation (100 Hz) of isolated giant axons of the small squid Alloteuthis subulata and the large squid Loligo forbesi caused the periaxonal Schwann cell resting potential (Em = -40 mV) to hyperpolarize up to 11 mV in direct proportion to train duration and action potential amplitude. In both species, the Schwann cell also hyperpolarized up to 17 mV with the application of L-glutamate (10(-9) to 10(-6) M), in a dose-dependent manner. By contrast, in the presence of 10(-8) M d-tubocurarine (d-TC) to block the cholinergic component of the Schwann cell response, Schwann cells depolarized 8-9 mV during electrical stimulation of the axon or application of L-glutamate. In the presence of 10(-5) M 2-amino-4-phosphonobutyrate (2-APB), the hyperpolarization to glutamate and to axon stimulation was blocked, whereas the cholinergic (carbachol-induced) hyperpolarization was unaffected. In experiments with Alloteuthis, L-aspartate (10(-7) M) also caused a Schwann cell hyperpolarization, but this was not blocked by 2-APB. In tests with glutamate receptor agonists and antagonists, quisqualate (10(-5) M) produced a hyperpolarization blocked by 10(-4) M L-glutamic acid diethylester (GDEE), which also blocked the response to axonal stimulation. Kainic acid (10(-4) M) also caused a hyperpolarization, but n-methyl-D-aspartate (NMDA; 10(-4) M), ibotenate (10(-5) M), alpha-amino-3-hydroxy-5-methyl-isoxazole proprionate (AMPA; (10(-4) M), and isethionate (10(-5) M) had no effect.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 63%

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

Lieberman¹,

Abbott²,

Hassan³

1989

Glia

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“…Due to its electrogenicity, the NBC in the outward direction can be stimulated by hyperpolarization of the glial membrane. Glial hyperpolarizations have been recorded in various glial cells after neuronal stimulation (Evans et al . 1986; Gommerat and Gola 1996; Schmidt and Deitmer 1999).…”

Section: Regulation and Interactions Of The Glial Transportersmentioning

confidence: 99%

A role for CO₂ and bicarbonate transporters in metabolic exchanges in the brain

Deitmer

2002

Journal of Neurochemistry

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Acid-base transporters are linked to the energy metabolism via the end product of oxidative metabolism, carbon dioxide, together with carbonic anhydrase activity. In a tissue such as the brain, where some cells (neurones) are high-energy consumers when active, and other cells (astroglial cells) are destined for homeostatic and trophic tasks, transport systems may complement each other and cooperate in order to maintain physiological functions. Here, some aspects of the coupling of metabolite shuttling and acid/base-dependent transport in neurones and glial cells are discussed.

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“…With regard to signals modulating the delivery of glial RNAs to the axon, our data indicate that they include neurotransmitters released by the stimulated axon and binding to glial glutamatergic and cholinergic receptors (Lieberman et al ., 1994; Gafurov et al ., 2001; Giuditta et al ., 2002a). Accordingly, as periaxonal glial cells are known to also contain additional receptors (Evans et al ., 1986; Reale et al ., 1986), future investigations are likely to reveal additional complex features of the axon–glia signalling network. Clear hints in this direction are provided by the multiple waves of enhanced delivery of radiolabelled RNA to the axon perfusate (Fig.…”

Section: Discussionmentioning

confidence: 99%

Local synthesis of axonal and presynaptic RNA in squid model systems

Eyman

Cefaliello

Ferrara

et al. 2007

Eur J of Neuroscience

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The presence of active systems of protein synthesis in axons and nerve endings raises the question of the cellular origin of the corresponding RNAs. Our present experiments demonstrate that, besides a possible derivation from neuronal cell bodies, axoplasmic RNAs originate in periaxonal glial cells and presynaptic RNAs derive from nearby cells, presumably glial cells. Indeed, in perfused squid giant axons, delivery of newly synthesized RNA to the axon perfusate is strongly stimulated by axonal depolarization or agonists of glial glutamate and acetylcholine receptors. Likewise, incubation of squid optic lobe slices with [3H]uridine leads to a marked accumulation of [3H]RNA in the large synaptosomes derived from the nerve terminals of retinal photoreceptor neurons. As the cell bodies of these neurons lie outside the optic lobe, the data demonstrate that presynaptic RNA is locally synthesized, presumably by perisynaptic glial cells. Overall, our results support the view that axons and presynaptic regions are endowed with local systems of gene expression which may prove essential for the maintenance and plasticity of these extrasomatic neuronal domains.

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Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre.

Cited by 37 publications

References 47 publications

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

A role for CO₂ and bicarbonate transporters in metabolic exchanges in the brain

Local synthesis of axonal and presynaptic RNA in squid model systems

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Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre.

Cited by 37 publications

References 47 publications

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

Evidence that glutamate mediates Axon‐to‐Schwann cell signaling in the squid

A role for CO2 and bicarbonate transporters in metabolic exchanges in the brain

Local synthesis of axonal and presynaptic RNA in squid model systems

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A role for CO₂ and bicarbonate transporters in metabolic exchanges in the brain