Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty

Bartolomé, Mercedes Alvarez; Borque, M.J.; Martinez-Sarmiento, Javier; Aparicio, Eugenio; Hernández, Carmen; Cabrerizo, Lucio; Fernandez-Represa, Jesus A.

doi:10.1381/096089202321088084

Cited by 125 publications

(58 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data are consistent with previous studies in OB, which have disclosed lower (fasting and postprandial) PYY levels than in controls (23,28,29).…”

Section: Discussionsupporting

confidence: 93%

“…Reportedly, the anorectic effect of PYY is preserved in patients with morbid obesity (OB), who under baseline conditions exhibit reduced fasting and postprandial levels of the peptide (28). Along this line, a negative association between PYY concentrations and markers of adiposity has been reported in some, but not all, studies in adults, children, and infants (28)(29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

Rigamonti

Cella

Bonomo

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin release-inhibiting factor (SRIF)) reportedly inhibits plasma PYY concentrations in animals and healthy humans, but the effect of a SRIF infusion on spontaneous PYY secretion in AN and OB is unknown. Methods: A total of 18 young women, seven with acute AN (A-AN), four with AN in the recovery phase (R-AN), and seven with morbid OB, were studied. All subjects underwent an infusion of SRIF (9 mg/kg i.v./h, over 60 min), with blood samples drawn before and at different time intervals after SRIF administration. Plasma PYY levels were measured at each time point. Results: SRIF significantly inhibited plasma PYY concentrations in R-AN and OB, without affecting PYY titers in A-AN. In OB, the inhibitory effect of SRIF also persisted at 90 min. Withdrawal of SRIF infusion in R-AN resulted in a prompt restoration of basal plasma PYY levels, whereas termination of SRIF infusion in OB was followed by a slower increase of PYY titers toward baseline levels. After infusion, PYY D area under the curve (DAUC) in R-AN was significantly higher than those in A-AN and OB patients. A significant difference in PYY DAUC between A-AN and OB was present. Conclusions: These results suggest the existence of a hypo-and hyper-sensitivity of L cells to the inhibitory effect of SRIF in A-AN and OB respectively.

show abstract

“…Our data are consistent with previous studies in OB, which have disclosed lower (fasting and postprandial) PYY levels than in controls (23,28,29).…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

Rigamonti

Cella

Bonomo

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…PYY and GLP-1 are satiety signals released by the endocrine L cells of the gastrointestinal tract after meals that have been shown to reduce food intake and body weight gain in obese Zucker rats [43][44][45]. In humans, fasting and post-prandial plasma levels of PYY increase progressively 6 and 12 months after vertical banded gastroplasty surgery [46]. Some authors have found that the PYY area under the curve after a test meal was also superior in obese patients submitted to gastric banding when compared weight-matched obese controls [15], although in another similar study, this was not found to be the case [47].…”

Section: Discussionmentioning

confidence: 99%

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

et al. 2007

View full text Add to dashboard Cite

Background Gastric banding is thought to decrease appetite in addition to the mechanical effects of food restriction, although this has been difficult to demonstrate in human studies. Our aim was to investigate the changes in orexigenic signals in the obese Zucker rat after gastric banding. Methods Obese Zucker rats ( fa/fa) were submitted to gastric banding (GBP), sham gastric banding fed ad libitum (sham), or sham operation with food restriction, pair-fed to the gastric banding group (sham-PF). Lean Zucker rats ( fa/+) were used as additional controls. Body weight and food intake were daily recorded for 21 days after surgery when epididymal fat was weighed and fasting ghrelin and hypothalamic NPY mRNA expression were measured. Results Gastric banding in obese Zucker rats resulted in a significant decrease of cumulative body weight gain and food intake. Furthermore, gastric banded rats were leaner than Sham-PF, as expressed by a significantly lower epididymal fat weight. Ghrelin levels of gastric banded rats were not increased when compared to sham-operated animals fed ad libitum and were significantly lower than the levels of weight matched sham-PF rats (1116.9±103.3 g GBP vs 963.2±54.3 g sham, 3,079.5±221.6 sham-PF and 2,969.9±150.9 g lean rats, p<0.001); hypothalamic NPY mRNA expression was not increased in GBP when compared to sham-operated rats. Conclusion In obese Zucker rats, GBP prevents the increase in orexigenic signals that occur during caloric deprivation. Our data support the hypothesis that sustained weight loss observed after gastric banding does not depend solely on food restriction.

show abstract

“…Thus, this post-operative increase in PYY secretion may be unique to RYGB, and not induced by the purely restrictive LAGB procedure. However, a single series of 12 patients undergoing VBG (also purely restrictive) reported an increase in fasting and post-prandial PYY after surgery to levels comparable to those measured lean controls [103].…”

Section: The Pancreatic Polypeptide Family: Pyy 3-36 and Ppmentioning

confidence: 87%

Bariatric surgery for extreme adolescent obesity: Indications, outcomes, and physiologic effects on the gut–brain axis

Xanthakos

2008

Pathophysiology

View full text Add to dashboard Cite

Objective-This review will summarize current indications, limitations and outcomes of bariatric surgery in adolescents, as well as provide an overview of the physiologic effects of bariatric surgery on enteric hormones involved in regulating appetite, satiation and maintenance of weight.Results-Extreme obesity (BMI ≥ 99 percentile) now affects 4% of children and adolescents in the United States. Traditional dietary and behavioral weight management methods have no demonstrated efficacy for extremely obese children and adolescents, in contrast with bariatric surgery which has produced significant and sustainable weight loss and associated improvements in comorbid diseases for the extremely obese. Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are the most commonly performed bariatric surgical procedures in adolescents, but vertical sleeve gastrectomy may be a promising new option for selected extremely obese adolescents. A mean weight loss of 37-40% is achieved in adolescents after RYGB, with LAGB showing similar results, albeit attained at a slower rate.Conclusion-Alterations in the enteric hormones involved in the gut-brain axis that regulates appetite and energy expenditure may play a role in both the anorexigenic and weight-reducing effects of certain bariatric surgical procedures. In particular, RYGB induces a rise in both fasting and post-prandial peptide tyrosine-tyrosine which could contribute to the more rapid and greater degree of weight loss than is seen with LAGB. Limitations of bariatric surgery however include the potential for post-operative morbidity and mortality, as well as possible weight regain in a small proportion of patients.

show abstract

Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty

Abstract: PYY concentration is lower in MO patients compared with non-obese. After VBG, PYY concentration gradually rises to the control levels.

Cited by 125 publications

References 15 publications

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

Bariatric surgery for extreme adolescent obesity: Indications, outcomes, and physiologic effects on the gut–brain axis

Contact Info

Product

Resources

About