Peptide YY (3–36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons

Domingues, Michelle Flores; Assis, Dênis Reis de; Piovesan, Angela Regina; Belo, Cháriston André Dal; Costa, Jaderson Costa da

doi:10.1016/j.npep.2017.11.003

Cited by 6 publications

(5 citation statements)

References 44 publications

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“…Following secretion by intestinal neuroendocrine L cells, peptide YY is hydrolyzed rapidly to PYY (3–36) [ 103 ]. PYY (1–36) and PYY (3–36) are both capable of crossing the blood brain barrier, with the latter being more active and abundant [ 104 , 105 , 106 ]. PYY (3–36) is a preferential agonist of the Y2 receptors [ 104 ].…”

Section: Diverse Stimuli Evoke Vomiting Via Distinct Receptorsmentioning

confidence: 99%

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Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

Zhong

Shahbaz

Teskey

et al. 2021

IJMS

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Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/bacteria/viruses/fungi enter the body either via the enteral (e.g., the gastrointestinal tract) or parenteral routes, including the blood, skin, and respiratory systems. While vomiting is the act of forceful removal of gastrointestinal contents, nausea is believed to be a subjective sensation that is more difficult to study in nonhuman species. In this review, the authors discuss the anatomical structures, neurotransmitters/mediators, and corresponding receptors, as well as intracellular emetic signaling pathways involved in the processes of nausea and vomiting in diverse animal models as well as humans. While blockade of emetic receptors in the prevention of vomiting is fairly well understood, the potential of new classes of antiemetics altering postreceptor signal transduction mechanisms is currently evolving, which is also reviewed. Finally, future directions within the field will be discussed in terms of important questions that remain to be resolved and advances in technology that may help provide potential answers.

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Section: Diverse Stimuli Evoke Vomiting Via Distinct Receptorsmentioning

confidence: 99%

“…PYY (1–36) and PYY (3–36) are both capable of crossing the blood brain barrier, with the latter being more active and abundant [ 104 , 105 , 106 ]. PYY (3–36) is a preferential agonist of the Y2 receptors [ 104 ].…”

Section: Diverse Stimuli Evoke Vomiting Via Distinct Receptorsmentioning

confidence: 99%

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

Zhong

Shahbaz

Teskey

et al. 2021

IJMS

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“…Within the brain, NPY can support neuronal health and function by stimulating the release of nerve growth factors, reducing neuroinflammation, stimulating autophagy and neurogenesis and as an inhibitor of excitotoxicity (Aveleira et al., 2015; Croce et al., 2012; Li et al., 2014; dos Santos et al., 2013; Silva et al., 2003; Spencer et al., 2016). Furthermore, neuroprotective qualities have been attributed to NPY’s roles in the modulation of neuronal physiology through regulation of calcium homoeostasis, neurotransmitter release and synaptic excitability (Baraban, Hollopeter, Erickson, Schwartzkroin, & Palmiter, 1997; Domingues, de Assis, Piovesan, Belo, & da Costa, 2018; Silva, Carvalho, Carvalho, & Malva, 2001). NPY effects are largely mediated at the post‐synapse through Y1, Y4, Y5 and Y6 receptors, however, negative regulation of NPY release is reported to occur through pre‐synaptic Y2 receptor activation on NPY containing neurons (Parker & Balasubramaniam, 2008).…”

Section: The Npy System and Npy Involvement In Alsmentioning

confidence: 99%

Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis

Clark

Hoyle

et al. 2020

Journal of Neurochemistry

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Neuropeptide Y (NPY) is an endogenous peptide of the central and enteric nervous systems which has gained significant interest as a potential neuroprotective agent for treatment of neurodegenerative disease. Amyotrophic lateral sclerosis (ALS) is an aggressive and fatal neurodegenerative disease characterized by motor deficits and motor neuron loss. In ALS, recent evidence from ALS patients and animal models has indicated that NPY may have a role in the disease pathogenesis. Increased NPY levels were found to correlate with disease progression in ALS patients. Similarly, NPY expression is increased in the motor cortex of ALS mice by end stages of the disease. Although the functional consequence of increased NPY levels in ALS is currently unknown, NPY has been shown to exert a diverse range of neuroprotective roles in other neurodegenerative diseases; through modulation of potassium channel activity, increased production of neurotrophins, inhibition of endoplasmic reticulum stress and autophagy, reduction of excitotoxicity, oxidative stress, neuroinflammation and hyperexcitability. Several of these mechanisms and signalling pathways are heavily implicated in the pathogenesis of ALS. Therefore, in this review, we discuss possible effects of NPY and NPY‐receptor signalling in the ALS disease context, as determining NPY’s contribution to, or impact on, ALS disease mechanisms will be essential for future studies investigating the NPY system as a therapeutic strategy in this devastating disease.

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“…Primary hippocampal cultures were prepared as described previously (Domingues et al 2018). Briefly, 1-to 2-day-old Wistar rats were killed by cervical dislocation and decapitated.…”

Section: Primary Culture Of Rat Hippocampus Cellsmentioning

confidence: 99%

“…Ca 2+ imaging experiments were performed following the method described in (Domingues et al 2018). All imaging experiments were performed on a digital epifluorescence imaging system (WinFluor, J. Dempster, University of Strathclyde) mounted on a Nikon TE 2000 microscope using a 20x objective.…”

Section: Ca 2+ Imaging Of Primary Hippocampal Culturesmentioning

confidence: 99%

Neurotoxic and convulsant effects induced by jack bean ureases on the mammalian nervous system

et al. 2021

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Peptide YY (3–36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons

Cited by 6 publications

References 44 publications

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis

Neurotoxic and convulsant effects induced by jack bean ureases on the mammalian nervous system

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