Peptide transporters and their roles in physiological processes and drug disposition

Rubio‐Aliaga, Isabel; Daniel, Hannelore

doi:10.1080/00498250701875254

Cited by 224 publications

(143 citation statements)

References 137 publications

Supporting

Mentioning

138

Contrasting

Order By: Relevance

“…PepT1 has also been exploited to allow delivery of therapeutic pro-drugs, such as those for zidovudine (zidovudine) [218], sulpiride [508] and cytarabine [457]. D-Ala-Lys-AMCA has been used as a fluorescent probe to identify transport via both PepT1 and PepT2 [416] . …”

Section: Further Readingmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

Alexander

Kelly

Marrion

et al. 2015

British J Pharmacology

190

View full text Add to dashboard Cite

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/ 10.1111/bph.13355/full. G protein-coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates. Conflict of interestThe authors state that there are no conflicts of interest to declare.

show abstract

Section: Further Readingmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

Alexander

Kelly

Marrion

et al. 2015

British J Pharmacology

190

View full text Add to dashboard Cite

show abstract

“…cathepsins B, K and L) and leads to the solubilization of the covalently crosslinked Tg and to the rapid liberation of thyroxine from the pro-hormone (Brix et al, 1996;Tepel et al, 2000;Brix et al, 2001;Friedrichs et al, 2003). According to this scenario, at the thyroid follicular level PEPT2 may be localized, as generally found in epithelia (Daniel and Kottra, 2004;Daniel et al, 2006;Rubio-Aliaga and Daniel, 2008), at the apical membrane of the thyrocyte where it could be involved in the uptake and recycling of peptide-bound amino acids derived from the extracellular Tg proteolysis occurring in the lumen of the thyroid follicles.…”

Section: Rt-pcr Experiments Confirmed Expression Of Pept2 In Pc Cl3 Cmentioning

confidence: 97%

“…PEPT1 and PEPT2 have been characterized in great detail (Daniel and Kottra, 2004;Daniel et al, 2006;Rubio-Aliaga and Daniel, 2008). Both proteins utilize an inwardly-directed H + gradient to translocate di-and tripeptides across plasma membranes.…”

Section: Introductionmentioning

confidence: 99%

“…Both proteins utilize an inwardly-directed H + gradient to translocate di-and tripeptides across plasma membranes. They also transport a variety of pharmacologically important compounds such as β-lactam antibiotics, renin inhibitors, the aminopeptidase inhibitor bestatin, -aminolevulinic acid and many selected pro-drugs (Brandsch et al, 2008;Rubio-Aliaga and Daniel, 2008). PEPT1 is a low-affinity/high-capacity transporter, mainly expressed in small intestinal epithelial cells and, to a smaller extent, in renal proximal tubular cells and bile duct epithelium.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional expression of SLC15 peptide transporters in rat thyroid follicular cells

Romano

Barca²,

Kottra³

et al. 2010

Molecular and Cellular Endocrinology

Self Cite

View full text Add to dashboard Cite

International audiencePeptide transport and expression of SoLute Carrier 15 (SLC15) peptide transporters was assessed in rat thyroid tissue and a rat thyroid cell line (PC Cl3 cells). Peptide transport was studied by monitoring the uptake of the fluorophore-conjugated dipeptide β-Ala-Lys-N-7-amino-4-methyl-coumarin-3-acetic acid (Ala-Lys-AMCA). Expression of SLC15-specific mRNA transcripts was analyzed by RT-PCR. Of the two SLC15 transporters expressed in thyroid follicular cells, namely PEPT2 (SLC15A2) and PHT1 (SLC15A4), only PEPT2 was involved in peptide transport at the plasma membrane, with PHT1 most likely being intracellular. Interestingly, at the mRNA level PEPT2 was up-regulated under TSH stimulation. These findings represent the first evidence that peptide transport occurs in thyroid follicular cells. SLC15 transporters could participate to recycling of peptides derived from extracellular and lysosomal thyroglobulin proteolysis, both essential steps for thyroid hormone synthesis

show abstract

“…It is well documented that transporters in the intestine, liver, kidney and brain are involved in the uptake and the efflux of chemical substances like food and drugs (Brandsch et al, 2008;Oostendorp et al, 2009;Rubio-Aliaga & Daniel, 2008;Zhou, 2008). The pharmacological effect and the disposition of drugs are thus highly influenced by the function of transporters located in specific tissues (Ayrton & Morgan, 2008;Calcagno et al, 2007;Türk & Szakács, 2009;Yuan et al, 2008).…”

Section: The Sites and The Mechanisms Of Xenobiotic-host Interactionmentioning

confidence: 99%