Peptide Nanotube Nematic Phase

Bucak, Şeyda; Cenker, Çelen Çağrı; Nasir, Irem; Olsson, Ulf; Zackrisson, M.

doi:10.1021/la804175h

Cited by 78 publications

(83 citation statements)

References 20 publications

(26 reference statements)

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“…The latter is predominantly occupied by charged and polar amino acids; these are: arginine (R), [6,7] histidine (H), [7,8] lysine (K), [9][10][11][12][13][14][15] aspartic acid (D), [16,17] glutamic acid (E), [11,18] serine (S), threonine (T), asparagine (N), glutamine (Q), and cysteine (C). [13] The design of the hydrophobic part is based on amino acids with neutral and nonpolar side-chains such as glycine (G), [16] alanine (A), [15,19] valine (V), [17,20] leucine (L), [9,17] isoleucine (I), [21] methionine (M), phenylalanine (F), [22,23] tyrosine (Y), and tryptophan (W). [7,[10][11][12][13][14]23] Depending on the hydrophobic to hydrophilic ratio and the sequence, various self-assembled structures can be constructed -as indicated in the associated references for the above amino acids -although the hydrophobicity is moderated by the polar character of the peptide's backbone.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled Structures from Amphiphilic Peptides

Sigg¹,

Schuster²,

Meier

2013

Chimia

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Nanotechnology and its applications are strongly influenced by structures self-assembled from a variety of different materials. This review covers nanostructures, including micelles, rod-like micelles, fibers and peptide beads, self-assembled from de novo designed amphiphilic peptides. The latter are promising candidates for the development of nanoscale carrier systems because they are completely composed of amino acids. In addition to designing primary sequences, secondary structure and external parameters are also discussed with respect to their impact on self-assembly. Moreover, the assembly process itself is examined. Potential applications range from gene and drug delivery devices to diagnostics, thereby highlighting the versatility of the system.

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Section: Introductionmentioning

confidence: 99%

Self-assembled Structures from Amphiphilic Peptides

Sigg¹,

Schuster²,

Meier

2013

Chimia

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“…Other candidate organic crystals that can have titratable surface or near-surface groups include crystals of small dicarboxylic acids that have been probed with AFM, such as the calcium oxalate monohydrate and dihydrate crystals found in kidney stones [76], and cocrystals containing glutarate [77]. Assemblies of small peptides, some of which spontaneously form large cylindrical structures with exposed titratable side chains [78,79], could be another context in which surface protonation patterns like those simulated here may form under appropriate solution conditions. Facets of oxide crystals in water represent another possibility [80,81].…”

Section: Further Discussion and Conclusionmentioning

confidence: 99%

Charge-regulation phase transition on surface lattices of titratable sites adjacent to electrolyte solutions: An analog of the Ising antiferromagnet in a magnetic field

Shore

Thurston

2015

Phys. Rev. E

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We report a charge-patterning phase transition on two-dimensional square lattices of titratable sites, here regarded as protonation sites, placed in a low-dielectric medium just below the planar interface between this medium and a salt solution. We calculate the work-of-charging matrix of the lattice with use of a linear Debye-Hückel model, as input to a grand-canonical partition function for the distribution of occupancy patterns. For a large range of parameter values, this model exhibits an approximate inverse cubic power-law decrease of the voltage produced by an individual charge, as a function of its in-lattice separation from neighboring titratable sites. Thus, the charge coupling voltage biases the local probabilities of proton binding as a function of the occupancy of sites for many neighbors beyond the nearest ones. We find that even in the presence of these longer-range interactions, the site couplings give rise to a phase transition in which the site occupancies exhibit an alternating, checkerboard pattern that is an analog of antiferromagnetic ordering. The overall strength W of this canonical charge coupling voltage, per unit charge, is a function of the Debye length, the charge depth, the Bjerrum length, and the dielectric coefficients of the medium and the solvent. The alternating occupancy transition occurs above a curve of thermodynamic critical points in the (pH-pK,W) plane, the curve representing a charge-regulation analog of variation of the Néel temperature of an Ising antiferromagnet as a function of an applied, uniform magnetic field. The analog of a uniform magnetic field in the antiferromagnet problem is a combination of pH-pK and W, and 1/W is the analog of the temperature in the antiferromagnet problem. We use Monte Carlo simulations to study the occupancy patterns of the titratable sites, including interactions out to the 37th nearest-neighbor category (a distance of 74 lattice constants), first validating simulations through comparison with exact and approximate results for the nearest-neighbor case. We then use the simulations to map the charge-patterning phase boundary in the (pH-pK,W) plane. The physical parameters that determine W provide a framework for identifying and designing real surfaces that could exhibit charge-patterning phase transitions.

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“…The self-assembly of AnK is concentration dependent. A6K was found to self-assemble above a critical concentration in aqueous solutions and form hollow nanotubes with a radius of 26 nm (Figure 2C), followed by a transition to a nematic lamellar phase with increasing peptide concentration (Bucak et al, 2009;Castelletto et al, 2010;Cenker et al, 2011). A4K could not self-assemble to form nanostructures.…”

Section: Small Surfactant-like Peptide Based On the Silk Protein Domainmentioning

confidence: 99%

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

Cheng

Lee

2016

Front. Mater.

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Silks produced by spiders and silkworms are charming natural biological materials with highly optimized hierarchical structures and outstanding physicomechanical properties. The superior performance of silks relies on the integration of a unique protein sequence, a distinctive spinning process, and complex hierarchical structures. Silks have been prepared to form a variety of morphologies and are widely used in diverse applications, for example, in the textile industry, as drug delivery vehicles, and as tissue engineering scaffolds. This review presents an overview of the organization of natural silks, in which chemical and physical functions are optimized, as well as a range of new materials inspired by the desire to mimic natural silk structure and synthesis.

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Peptide Nanotube Nematic Phase

Cited by 78 publications

References 20 publications

Self-assembled Structures from Amphiphilic Peptides

Self-assembled Structures from Amphiphilic Peptides

Charge-regulation phase transition on surface lattices of titratable sites adjacent to electrolyte solutions: An analog of the Ising antiferromagnet in a magnetic field

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

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