Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics

Li, Shukun; Zou, Qianli; Xing, Ronge; Govindaraju, T.; Fakhrullin, Rawil; Yan, Xuehai

doi:10.7150/thno.31814

Cited by 61 publications

(35 citation statements)

References 120 publications

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“…Nanoparticles’ conjungtion with inter alia tumor-homing peptides is an attractive avenue for tumor-targeted therapy [ 136 , 137 ]. The advances in the synthesis of supra-molecular assemblies prompt the development of theranostics (which possess specific smart features, such as programmability, multifunctionality, sensitivity, precise selectivity, biosafety) and are promising agents for personalized, smart medicine [ 126 , 138 , 139 ].…”

Section: Frontiers and Prospects Of Short Peptidesmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

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Section: Frontiers and Prospects Of Short Peptidesmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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“…Meanwhile, peptides or proteins are also promising candidates for modulating self-assembly of phototherapeutic nanoparticles; they exhibit structural or functional diversity and high biocompatibility or biodegradability [ 82 , 83 ]. Self-assembly of photosensitizers could be tuned by a dipeptide or amphiphilic amino acid, resulting in the enhanced PDT efficacy in mice.…”

Section: Advances In Nanomedicine For Pdt To Overcome Current Clinmentioning

confidence: 99%

Current Limitations and Recent Progress in Nanomedicine for Clinically Available Photodynamic Therapy

et al. 2021

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Photodynamic therapy (PDT) using oxygen, light, and photosensitizers has been receiving great attention, because it has potential for making up for the weakness of the existing therapies such as surgery, radiation therapy, and chemotherapy. It has been mainly used to treat cancer, and clinical tests for second-generation photosensitizers with improved physicochemical properties, pharmacokinetic profiles, or singlet oxygen quantum yield have been conducted. Progress is also being made in cancer theranostics by using fluorescent signals generated by photosensitizers. In order to obtain the effective cytotoxic effects on the target cells and prevent off-target side effects, photosensitizers need to be localized to the target tissue. The use of nanocarriers combined with photosensitizers can enhance accumulation of photosensitizers in the tumor site, owing to preferential extravasation of nanoparticles into the tumor vasculature by the enhanced permeability and retention effect. Self-assembly of amphiphilic polymers provide good loading efficiency and sustained release of hydrophobic photosensitizers. In addition, prodrug nanomedicines for PDT can be activated by stimuli in the tumor site. In this review, we introduce current limitations and recent progress in nanomedicine for PDT and discuss the expected future direction of research.

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“…Strategies combining diagnosis and therapy, namely theranostics, that allow simultaneous detection of targets 3 , monitoring of drug distribution 5 , and the evaluation of therapeutic responses 6 to achieve personalized medicine 7 have attracted great interest. Recent rapid developments in nanotechnologies have encouraged researchers to develop nanoparticle-based transport platforms for co-delivery of diagnosis and therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Recent progress of nanotechnology-based theranostic systems in cancer treatments

Xue¹,

Gao²,

Meng³

et al. 2021

Cancer Biol. Med.

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Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest, and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy. Nanoparticles are ideal candidates as carriers for theranostic agents, which is attributed to their extraordinary physicochemical properties, including nanoscale sizes, functional properties, prolonged blood circulation, active or passive tumor targeting, specific cellular uptake, and in some cases, excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time. Overall, with the development of nanotechnology, theranostics has become a reality, and is now in the transition stage of "bench to bedside." In this review, we summarize recent progress on nanotechnology-based theranostics, i.e., nanotheranostics, that has greatly assisted traditional therapies, and has provided therapeutic strategies emerging in recent decades, as well as "cocktail" theranostics mixing various treatment modalities.

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Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics

Cited by 61 publications

References 120 publications

A Global Review on Short Peptides: Frontiers and Perspectives

A Global Review on Short Peptides: Frontiers and Perspectives

Current Limitations and Recent Progress in Nanomedicine for Clinically Available Photodynamic Therapy

Recent progress of nanotechnology-based theranostic systems in cancer treatments

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