Peptide ligand-mediated trade-off between plant growth and stress response

Ogawa-Ohnishi, Mari; Yamashita, Tomohide; Kakita, Mitsuru; Nakayama, Takuya; Ohkubo, Yuri; Hayashi, Yoko; Yamashita, Yasuko; Nomura, Taizo; Noda, Satoshi; Shinohara, Hidefumi; Matsubayashi, Yoshikatsu

doi:10.1126/science.abq5735

Cited by 42 publications

(54 citation statements)

References 38 publications

(47 reference statements)

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“…A combination of these conditions variably induces the response. A similar mechanism, in which ligand depletion activates the transcriptional response, has been recently reported in plants [98].…”

Section: If Asa Is So Much Important Why Did We Lose Asa Biosynthetic...supporting

confidence: 72%

The Function of Ascorbic Acid through Occam’s Razor: What We Know, What We Presume and What We Hope For

Tullio¹

2024

Ascorbic Acid - Biochemistry and Functions

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After being identified as the anti-scurvy factor vitamin C, ascorbic acid (AsA) became the subject of an astonishing amount of research. Many studies confirmed that AsA is essential to plants and animals, however, the molecular mechanisms by which AsA exerts its action are only in part understood. Much attention has been given to the so-called antioxidant function of AsA, but the concept of antioxidant is in itself rather vague and, at least in some studies, proper quantitative approaches to assess the actual relevance of AsA as an antioxidant are lacking. On the other hand, in the last few decades more and more research focused on the specific function of AsA as a regulatory co-factor of 2-oxoglutarate-dependent dioxygenases, a large class of enzymes catalyzing an array of different and apparently unrelated reactions, all sharing a complex mechanism based on the integration of relevant pieces of molecular information. The present contribution aims to critically discuss available evidence in support of current hypotheses on AsA function.

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Section: If Asa Is So Much Important Why Did We Lose Asa Biosynthetic...supporting

confidence: 72%

The Function of Ascorbic Acid through Occam’s Razor: What We Know, What We Presume and What We Hope For

Tullio¹

2024

Ascorbic Acid - Biochemistry and Functions

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“…Plants evolved PGIPs to neutralize the destructive potential of polygalacturonases by decreasing and promoting production of short immunosuppressive and long immuno-eliciting oligogalacturonides, respectively. Hijacking host cell pathways is a common mechanism used by pathogens for their virulence activity ( 50 – 54 ). Our study provides an example of a similar tactic used by plants to exploit the virulence-essential glycoside hydrolase activity of pathogen-encoded polygalacturonases to benefit their survival (fig.…”

Section: Discussionmentioning

confidence: 99%

A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity

Xiao,

Sun,

et al. 2024

Science

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Polygalacturonase-inhibiting proteins (PGIPs) interact with pathogen-derived polygalacturonases to inhibit their virulence-associated plant cell wall–degrading activity but stimulate immunity-inducing oligogalacturonide production. Here we show that interaction between Phaseolus vulgaris PGIP2 (PvPGIP2) and Fusarium phyllophilum polygalacturonase (FpPG) enhances substrate binding, resulting in inhibition of the enzyme activity of FpPG. This interaction promotes FpPG-catalyzed production of long-chain immunoactive oligogalacturonides, while diminishing immunosuppressive short oligogalacturonides. PvPGIP2 binding creates a substrate binding site on PvPGIP2-FpPG, forming a new polygalacturonase with boosted substrate binding activity and altered substrate preference. Structure-based engineering converts a putative PGIP that initially lacks FpPG-binding activity into an effective FpPG-interacting protein. These findings unveil a mechanism for plants to transform pathogen virulence activity into a defense trigger and provide proof of principle for engineering PGIPs with broader specificity.

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“…IDA [INFLORESCENCE DEFICIENT IN ABSCISSION;(Vie et al, 2015)], PSK [PHYTOSULFOKINE; (Yang et al, 2001)], PSY [PLANT PEPTIDE CONTAINING SULFATED TYROSINE; (Amano et al, 2007;Ogawa-Ohnishi et al, 2022)], and RGF/GLV/CLEL [ROOT MERISTEM GROWTH FACTOR/GOLVEN/CLE-LIKE; (Matsuzaki et al, 2010;Meng et al, 2012;Whitford et al, 2012)], were present in the most recent common ancestor of vascular plants and bryophytes (Figure 1). These peptide families have followed contrasting evolutionary trajectories between vascular plants and bryophytes (Table 1).…”

Section: Evolution Of Small Signaling Peptidesmentioning

confidence: 99%

Land plant peptide signaling: What we know—and don't know—about its evolution

Furumizu,

Shinohara

2024

Physiologia Plantarum

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The availability of genome sequences from diverse algal and plant taxa combined with the refinement of comparative genomics tools has begun to reveal how land plant genomes were shaped through duplication, repeat expansion, and gene family gains and losses. Of particular note is a large increase in the complexity and variety of signaling systems in land plants. Among these, signaling through small peptide ligand‐receptor interactions has been considered one of the major innovations during land plant evolution. First discovered in angiosperms as mediators of various cell‐to‐cell communication processes, peptide signaling studies have been expanded to non‐angiosperms, including bryophytes. Recent studies point to both common and unique roles for peptide signaling in distantly related species, raising interesting questions about how peptide signaling systems evolved and diversified. While the origin of peptide signaling systems remains elusive, progress in sequencing algal genomes offers clues to understanding the evolution of peptide receptors. This article discusses recent studies of small peptide‐mediated signaling systems and highlights current gaps in our knowledge and new avenues for research, which could help us address how peptide signaling systems evolved and contributed to plant terrestrialization.

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Peptide ligand-mediated trade-off between plant growth and stress response

Cited by 42 publications

References 38 publications

The Function of Ascorbic Acid through Occam’s Razor: What We Know, What We Presume and What We Hope For

The Function of Ascorbic Acid through Occam’s Razor: What We Know, What We Presume and What We Hope For

A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity

Land plant peptide signaling: What we know—and don't know—about its evolution

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