Peptide/Graphene Hybrid Assembly into Core/Shell Nanowires

Han, Tae Hee; Lee, Wonjun; Lee, Jun Young; Kim, Ji Eun; Choi, Eun-Young; Kim, Sang Ouk

doi:10.1002/adma.200903221

Cited by 259 publications

(187 citation statements)

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“…The enriched functional groups can interact in an ionic, covalent or non-covalent manner, so that in principle they provide the highest extraction efficiency of biomolecules per unit area . In recent years, the functionalized GO has been exploited to fabricate biosensors for drug delivery Zhang et al, 2010a), bioimaging in living cells Sun et al, 2008), the detection of cancer cell (Tao et al, 2013), glucose (Song et al, 2010), DNA Gao et al, 2014), enzyme (Zhang et al, 2010b), protein , peptides (Han et al, 2010), and cellulose and lignin .…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

105

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We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability. The surface morphology of GO overlay was characterized by Atomic force microscopy, Scanning electron microscope, and Raman spectroscopy. By depositing the GO with a thickness of 49.2 nm, the sensitivity in refractive index (RI) of dLPG was increased to 2538 nm/RIU, 200% that of non-coated dLPG, in low RI region (1.333-1.347) where bioassays and biological events were usually carried out. The IgG was covalently immobilized on GO-dLPG via EDC/NHS heterobifunctional cross-linking chemistry leaving the binding sites free for target analyte recognition. The performance of immunosensing was evaluated by monitoring the kinetic bioaffinity binding between IgG and specific anti-IgG in real-time. The GO-dLPG based biosensor demonstrates an ultrahigh sensitivity with limit of detection of 7 ng/mL, which is 10-fold better than non-coated dLPG biosensor and 100-fold greater than LPG-based immunosensor. Moreover, the reusability of GO-dLPG biosensor has been facilitated by a simple regeneration procedure based on stripping off bound anti-IgG treatment. The proposed ultrasensitive biosensor can be further adapted as biophotonic platform opening up the potential for food safety, environmental monitoring, clinical diagnostics and medical applications.

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Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

105

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“…[11][12][13][14][15] Among various graphene-based materials, graphene oxide (GO), an aqueous dispersible oxygenated derivative of graphene, has been widely exploited for cost-effective solution processing of graphene-based materials. [16][17][18] GO can be thermally or chemically reduced or modified to tune the material properties, and has been successfully utilized in molecular hybrids [19,20] or composites, [21][22][23][24][25] biocompatible scaffolds or substrates, [26,27] and patterned carbon films. [28,29] In recent years, graphene-based biodevices, such as DNA carriers, [30,31] graphene nanopores for DNA sequencing, [32] and a graphene-DNA biosensor, [33,34] have been highlighted with extraordinary sensitivity, [34,35] rapid readout, [36] and good biostability.…”

mentioning

confidence: 99%

DNA Origami Nanopatterning on Chemically Modified Graphene

Yun

Kim

et al. 2011

Angew Chem Int Ed

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“…The uniform dispersion of SnO 2 on the graphene surface is ensured by controlling the zeta potential of each component. The diverse functional groups of chemically reduced graphene make it easy for the surface of graphene nanosheets (GNSs) to become negatively charged [27]. Because the SnO 2 particles can have a positive surface charge in a specific pH range, the SnO 2 particles can electrostatically attach themselves on the GNS.…”

Section: Introductionmentioning

confidence: 99%

SnO2/graphene composite with high lithium storage capability for lithium rechargeable batteries

et al. 2010

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SnO 2 /graphene nanocomposites have been fabricated by a simple chemical method. In the fabrication process, the control of surface charge causes echinoid-like SnO 2 nanoparticles to be formed and uniformly decorated on the graphene. The electrostatic attraction between a graphene nanosheet (GNS) and the echinoid-like SnO 2 particles under controlled pH creates a unique nanostructure in which extremely small SnO 2 particles are uniformly dispersed on the GNS. The SnO 2 /graphene nanocomposite has been shown to perform as a high capacity anode with good cycling behavior in lithium rechargeable batteries. The anode retained a reversible capacity of 634 mA·h·g -1 with a coulombic efficiency of 98% after 50 cycles. The high reversibility can be attributed to the mechanical buffering by the GNS against the large volume change of SnO 2 during delithiation/lithiation reactions. Furthermore, the power capability is significantly enhanced due to the nanostructure, which enables facile electron transport through the GNS and fast delithiation/lithiation reactions within the echinoid-like nanoSnO 2 . The route suggested here for the fabrication of SnO 2 /graphene hybrid materials is a simple economical route for the preparation of other graphene-based hybrid materials which can be employed in many different fields.

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Peptide/Graphene Hybrid Assembly into Core/Shell Nanowires

Cited by 259 publications

References 50 publications

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

DNA Origami Nanopatterning on Chemically Modified Graphene

SnO2/graphene composite with high lithium storage capability for lithium rechargeable batteries

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