Peptide Grafted and Self-Assembled Poly(γ-Glutamic Acid)-Phenylalanine Nanoparticles Targeting Camptothecin to Glioma

Kulhari, Hitesh; Telukutla, Srinivasa Reddy; Pooja, Deep; Shukla, Ravi; Sistla, Ramakrishna; Bansal, Vipul; Adams, David J.

doi:10.2217/nnm-2017-0067

Cited by 11 publications

(11 citation statements)

References 65 publications

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“…For instance, the Wang group showed that therapeutics such as docetaxel, 6 wortmannin, 7 and histone deacetylase inhibitors 8 can be delivered by nanoparticle carriers to tumors to enhance RT. Polyglutamic acid conjugated paclitaxel nanoparticles, also known as paclitaxel poliglumex (Xyotax), have been tested in the clinic to improve RT against glioma 9,10 and head and neck cancer. 11 Nanotechnology allows us to revisit therapeutics that may be potent radiosensitizers but too toxic to be administered alone.…”

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confidence: 99%

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

et al. 2020

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Radiotherapy remains a major treatment modality for cancer types such as non-small cell lung carcinoma (or NSCLC). To enhance treatment efficacy at a given radiation dose, radiosensitizers are often used during radiotherapy. Herein, we report a nanoparticle agent that can selectively sensitize cancer cells to radiotherapy. Specifically, we nitrosylated maytansinoid DM1 and then loaded the resulting prodrug, DM1-NO, onto poly(lactide-co-glycolic)-block-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles. The toxicity of DM1 is suppressed by nanoparticle encapsulation and nitrosylation, allowing the drug to be delivered to tumors through the enhanced permeability and retention effect. Under irradiation to tumors, the oxidative stress is elevated, leading to the cleavage of the S–N bond and the release of DM1 and nitric oxide (NO). DM1 inhibits microtubule polymerization and enriches cells at the G2/M phase, which is more radiosensitive. NO under irradiation forms highly toxic radicals such as peroxynitrites, which also contribute to tumor suppression. The two components work synergistically to enhance radiotherapy outcomes, which was confirmed in vitro by clonogenic assays and in vivo with H1299 tumor-bearing mice. Our studies suggest the great promise of DM1-NO PLGA nanoparticles in enhancing radiotherapy against NSCLC and potentially other tumor types.

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confidence: 99%

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

et al. 2020

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“…Another advantage of this material is that it is nontoxic and fully biodegradable, and has been used clinically. [26][27][28][29] PGA has been used as a carrier of various drugs and biomolecules, such as proteins, 30 vaccine 31 and genes, 32 to treat liver tumor, 33 glioma, 34 bladder and lung cancer cells. 35 However, whether PGA could be used as a carrier to treat RA was not known.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

Zhang¹,

Chang²,

Zhao³

et al. 2018

IJN

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Triptolide (TP) exhibits immunosuppressive, cartilage-protective and anti-inflammatory effects in rheumatoid arthritis. However, the toxicity of TP limits its widespread use. To decrease the toxic effects, we developed a novel nano-drug carrier system containing TP using poly-γ-glutamic acid-grafted di-tert-butyl L-aspartate hydrochloride (PAT). PAT had an average diameter of 79±18 nm, a narrow polydispersity index (0.18), a strong zeta potential (−32 mV) and a high drug encapsulation efficiency (EE1=48.6%) and loading capacity (EE2=19.2%), and exhibited controlled release (t1/2=29 h). The MTT assay and flow cytometry results indicated that PAT could decrease toxicity and apoptosis induced by free TP on RAW264.7 cells. PAT decreased lipopolysaccharides/interferon γ-induced cytokines expression of macrophage (P<0.05). In vivo, PAT accumulated at inflammatory joints, improved the survival rate and had fewer side effects on tumor necrosis factor α transgenic mice, compared to TP. The blood biochemical indexes revealed that PAT did not cause much damage to the kidney (urea nitrogen and creatinine) and liver (alanine aminotransferase and aspartate aminotransferase). In addition, PAT reduced inflammatory synovial tissue area (P<0.05), cartilage loss (P<0.05), tartrate-resistant acid phosphatase-positive osteoclast area (P<0.05) and bone erosion (P<0.05) in both knee and ankle joints, and showed similar beneficial effect as free TP. In summary, our newly formed nanoparticle, PAT, can reduce the toxicity and guarantee the efficacy of TP, which represents an effective drug candidate for RA with low adverse side effect.

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“…cRGD-epirubicin micelles showed a 12-fold increase in antitumor activity in an orthotopic GBM model compared to pristine micelles, and could also be employed to image the neovasculature in this model [ 116 ]. Kulhari et al conjugated different RGD (cRGDfK peptide) nanoparticles delivery of camptothecin to GBM, which resulted in more efficient ROS generation, induction of apoptosis and improved control over cell migration [ 87 ]. Another class of peptide, cell penetrating peptides (CPPs), have also been reported for the delivery into the brain [ 117 ].…”

Section: Delivery Of Bioactive From Sapsmentioning

confidence: 99%

Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels

Zhou

Tai

et al. 2023

Gels

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Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue engineering scaffolds. Using the tools of nature, they are a versatile framework for the supply and presentation of important biological factors. Recent developments have shown promise for many applications such as therapeutic gene, drug and cell delivery and yet are stable enough for large-scale tissue engineering. This is due to their excellent programmability—features can be incorporated for innate biocompatibility, biodegradability, synthetic feasibility, biological functionality and responsiveness to external stimuli. SAPs can be used independently or combined with other (macro)molecules to recapitulate surprisingly complex biological functions in a simple framework. It is easy to accomplish localized delivery, since they can be injected and can deliver targeted and sustained effects. In this review, we discuss the categories of SAPs, applications for gene and drug delivery, and their inherent design challenges. We highlight selected applications from the literature and make suggestions to advance the field with SAPs as a simple, yet smart delivery platform for emerging BioMedTech applications.

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Peptide Grafted and Self-Assembled Poly(γ-Glutamic Acid)-Phenylalanine Nanoparticles Targeting Camptothecin to Glioma

Abstract: cRGDfK-mediated and amphiphilic copolymer-based nanomedicines represent a new approach for improved delivery of anticancer drugs to and treatment of glioblastoma multiforme.

Cited by 11 publications

References 65 publications

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels

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Peptide Grafted and Self-Assembled Poly(γ-Glutamic Acid)-Phenylalanine Nanoparticles Targeting Camptothecin to Glioma

Abstract: cRGDfK-mediated and amphiphilic copolymer-based nanomedicines represent a new approach for improved delivery of anticancer drugs to and treatment of glioblastoma multiforme.

Cited by 11 publications

References 65 publications

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

Fabrication of a triptolide-loaded and poly-&gamma;-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels

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Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis