Peptide decoys: a new technology offering therapeutic opportunities for breast cancer

Mahjoubin‐Tehran, Maryam; Rezaei, Samaneh; Jalili, Amin; Aghaee‐Bakhtiari, Seyed Hamid; Orafai, Hossein; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1016/j.drudis.2020.01.010

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Therefore, ligand binding to the functional receptor is inhibited and the corresponding signaling pathway is suppressed. Decoy peptides are applied throughout various fields of research and have been demonstrated as an anticancer agent via a decoy receptor for Wnt ligands [34,36]. Importantly, decoy receptors constitute a novel and relatively unknown target for development of antiviral drugs [37] or as a therapeutic tool for inhibition of bacterial infections [38].…”

Section: Decoy Peptidementioning

confidence: 99%

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Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis

Mahjoubin‐Tehran

Teng

Jalili

et al. 2021

IJMS

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Cardiovascular diseases (CVDs) have been classified into several types of disease, of which atherosclerosis is the most prevalent. Atherosclerosis is characterized as an inflammatory chronic disease which is caused by the formation of lesions in the arterial wall. Subsequently, lesion progression and disruption ultimately lead to heart disease and stroke. The development of atherosclerosis is the underlying cause of approximately 50% of all deaths in westernized societies. Countless studies have aimed to improve therapeutic approaches for atherosclerosis treatment; however, it remains high on the global list of challenges toward healthy and long lives. Some patients with familial hypercholesterolemia could not get intended LDL-C goals even with high doses of traditional therapies such as statins, with many of them being unable to tolerate statins because of the harsh side effects. Furthermore, even in patients achieving target LDL-C levels, the residual risk of traditional therapies is still significant thus highlighting the necessity of ongoing research for more effective therapeutic approaches with minimal side effects. Decoy-based drug candidates represent an opportunity to inhibit regulatory pathways that promote atherosclerosis. In this review, the potential roles of decoys in the treatment of atherosclerosis were described based on the in vitro and in vivo findings.

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Section: Decoy Peptidementioning

confidence: 99%

“…Decoy peptides (or decoy receptors) are "sticky" proteins similar to functional receptors on cytokines and chemokines [ 34 ]. Decoy peptides are specifically designed to attract certain ligands such as inflammatory cytokines and compete with target receptors although decoy peptides do not initiate signaling ( Figure 2 ) [ 35 ].…”

Section: Decoymentioning

confidence: 99%

Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis

Mahjoubin‐Tehran

Teng

Jalili

et al. 2021

IJMS

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“…This is the premise of decoy base therapy where the drug candidates represent an opportunity to inhibit a known activated regulatory pathway that promotes CVD. Decoy technology includes two main approaches, decoy ODN and decoy peptides [9,10].…”

Section: Decoysmentioning

confidence: 99%

“…Reports for the usage of decoy ODN for reducing the expression of target genes including ER, CRE, STAT3, and Sp1 have shown potential therapeutic utility in breast cancer therapy [9]. It has also been shown that peptide decoys have a potential therapeutic effect for cancers such as breast cancer [10], bladder cancer [15], colon cancer [16], lung cancer [17], liver cancer [18], and prostate cancer [19]. In this review, we summarized studies that have investigated the effects of ODN and peptide decoys on non-atherosclerotic CVD (Table 1).…”

Section: Therapeutic Potential Of Decoysmentioning

confidence: 99%

Harnessing the Therapeutic Potential of Decoys in Non-Atherosclerotic Cardiovascular Diseases: State of the Art

Mahjoubin‐Tehran

Atkin

Bezsonov

et al. 2021

JCDD

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Cardiovascular disease (CVD) is the main cause of global death, highlighting the fact that conventional therapeutic approaches for the treatment of CVD patients are insufficient, and there is a need to develop new therapeutic approaches. In recent years, decoy technology, decoy oligodeoxynucleotides (ODN), and decoy peptides show promising results for the future treatment of CVDs. Decoy ODN inhibits transcription by binding to the transcriptional factor, while decoy peptide neutralizes receptors by binding to the ligands. This review focused on studies that have investigated the effects of decoy ODN and decoy peptides on non-atherosclerotic CVD.

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“…Breast cancer is a type of cencer which has the highest mortality rates and is the most common cancer in women Global Cancer Observatory (2021). There are novel therapeutic approaches being developed in breast cancer treatment nowadays Mahjoubin-Tehran et al (2020). Despite this, there is still need for effective methods in terms of cencer treatment.…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Boric Acid and Resveratrol on McF-7 Breast Cancer Cells Metastatic Behaviour

Aladağ

Fırat

2022

Int. J. Res. Granthaalayah

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Motivation/Background:The metastasis of tumor cells consists of steps such as epithelial-mesenchymal transition, transendothelial migration and the formation of metastatic colonization. E-Cadherin and vimentin are main proteins associated with EMT, whereas MMP-9 is associated with migration. Method:We aimed to investigate effects boric acid and resveratrol comparatively on metaatatic behaviors on MCF-7. 30μM boric acid and 50μM resveratrol were administered to BA, BA+RES, and RES groups 48hours. Cells stained immunocytochemically by Anti-E-Cadherin, Anti-Vimentin, and Anti-MMP-9 antibodies and H-Score analysis carried out and migration analyzed by woundhealing, morphologically. Results andConclusions:It’s been observed that boric acid doesn’t affect the EMT capability of the MCF-7 cells in terms of E-Cadherin and vimentin expression; whereas, it’s affect migration both by decreasing the MMP-9 expression and also by inhibiting migration.

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Peptide decoys: a new technology offering therapeutic opportunities for breast cancer

Cited by 14 publications

References 16 publications

Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis

Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis

Harnessing the Therapeutic Potential of Decoys in Non-Atherosclerotic Cardiovascular Diseases: State of the Art

Comparative Effects of Boric Acid and Resveratrol on McF-7 Breast Cancer Cells Metastatic Behaviour

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