Peptide Cotransmitter at a Neuromuscular Junction

Adams, Michael E.; O’Shea, Michael

doi:10.1126/science.6134339

Cited by 211 publications

(132 citation statements)

References 18 publications

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…R3-R14 are an addition to the growing list of neurons (HoKFELT et a!., 1980a, b;LUNDBERG et al, 1980;JAN and JAN, 1982;ADAMS and O'SHEA, 1983) which may release more than one neurochemical messenger. This is contrary to the one neuron-one neurotransmitter hypothesis, which seems to have been prematurely proposed (POTTER et a!.,1981).…”

Section: Discussionmentioning

confidence: 99%

Influences of glycine and neuron R14 on contraction of the anterior aorta of Aplysia.

Sawada¹,

McAdoo²,

Ichinose³

et al. 1984

Jpn.J.Physiol

View full text Add to dashboard Cite

Firing neuron R14 in the Aplysia parietovisceral ganglion enhances the force of stimulated contractions and causes rhythmic contractions rather than individual contractions in response to a single stimulation of the anterior aorta of Aplysia. Bath application of 1.0 mM glycine to the artery causes a small depolarization, rhythmic contractions and enhances the force of individual, neurally induced contractions of the anterior aorta. These observations suggest that the physiological role of the innervation of the anterior aorta by R14 is to convert the mode of contraction of the anterior aorta from direct neural control to a myogenic mode. R14 activity does not produce classical junction potentials and inotophoretically applied glycine does not produce detectable potential changes in the anterior aorta muscle fibers. Glycine increases the force and frequency of Aplysia heart beat, and blood pressure. Glycine causes release of preloaded Ca2+ from the ventricle of the Aplysia heart, implying that glycine causes intracellular release of Cat+. The similarity of the actions of glycine and electrical activity in R14 extend previous evidence that R14 may utilize glycine to modulate the contractility of Aplysia circulatory muscle.

show abstract

Section: Discussionmentioning

confidence: 99%

Influences of glycine and neuron R14 on contraction of the anterior aorta of Aplysia.

Sawada¹,

McAdoo²,

Ichinose³

et al. 1984

Jpn.J.Physiol

View full text Add to dashboard Cite

show abstract

“…Similar effects of high frequency stimulation have been seen in the cockroach coxal depressor muscle (Chesler and Fourtner, 1981) and locust extensoi-tibiae (Burns and Usherwood, 1978). More recent evidence indicates that both of these muscles are innervated by motoneurons which utilize 1-glutamate and proctolin as CO-transmitters, with 1-glutamate initiating twitches and proctolin causing increases of basic tonus (O' Adams and O'Shea, 1983;Wordon et al, 1985).…”

Section: Discussionmentioning

confidence: 53%

“…The cockroach coxal depressor (Adams and O'Shea, 1983) and locust extensor-tibiae (Wordon et al, 1985) both primarily respond by increasing their basic tonus.…”

Section: Effects Of Proctolinmentioning

confidence: 99%

“…• 'Shea, 1983), locust extensor-tibiae (Wordon et al, 1985), or lobster skeletal muscle . In all these preparations proctolin increased basic tonus without greatly increasing twitch amplitude.…”

Section: Effects Of Proctolinmentioning

confidence: 99%

“…The pentapeptide proctolin has at least two distinct types of actions on arthropod muscle; these include increases in basic tonus of a muscle (Adams and O'Shea, 1983;Wordon et al, 1985) and increases in the amplitude of muscle contraction Mercier and Wilkens, 1985). These effects are probably mediated by proctolin-containing motoneurons (O Agricola et al, 1982;Bishop et al, 1984a,b;Keshishian and O'Shea, 1985;Siwicki and Bishop, 1986).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of contractility and basic tonus in two serially homologous muscles in the cricket Teleogryllus oceanicus

O'Gara

View full text Add to dashboard Cite

Allatostatin‐like‐immunoreactive neurons of the tobacco hornworm, Manduca sexta , and isolation and identification of a new neuropeptide related to cockroach allatostatins

1997

View full text Add to dashboard Cite

The YXFGLamide C-terminus serves to define most members of a family of structurally related neuropeptides, the YXFGLamides. These peptides have been identified from the nervous system of various insects and include the allatostatins of cockroaches and crickets, the schistostatins of locusts, and the callatostatins of blowflies. The YXFGLamides have been shown to have various functions, including inhibition of juvenile hormone biosynthesis in cockroaches and crickets and inhibition of contraction of certain insect visceral muscles. We wanted to know if these peptides occur in Manduca sexta and what functions they might have. A new peptide, AKSYNFGLamide, was isolated and identified from M. sexta and has been named "lepidostatin-1"; this is the first YXFGLamide to be found in a lepidopteran, and there are indications that additional YXFGLamides occur in M. sexta. An antiserum to cockroach allatostatins (YXFGLamides) was shown to recognize lepidostatin-1 of M. sexta and was used to map YXFGLamide-immunoreactive neurons in larvae. Because immunoreactive interneurons were found to form an extensive neuropil, YXFGLamides probably function as neuromodulators in M. sexta. Neuroendocrine cells in the brain, abdominal ganglia, and their respective neurohemal organs were YXFGLamide immunoreactive and appear to release YXFGLamides as neurohormones. Immunoreactivity to YXFGLamides and M. sexta diuretic hormone were found to be colocalized and appear to be coreleased in these neuroendocrine cells, indicating that YXFGLamides may be involved in regulation of fluid transport. Innervation of the corpora allata by YXFGLamide-immunoreactive processes was very sparse, suggesting that this innervation does not play an important role in allatostasis. Many thoracic motor neurons were YXFGLamide immunoreactive, suggesting that YXFGLamides may have a myomodulatory or myotrophic function in larvae. However, this immunoreactivity disappeared early in metamorphosis and did not reappear in the adult. The YXFGLamide-immunoreactive neurons in the terminal abdominal ganglion were found to innervate the hindgut, indicating that YXFGLamides may be involved in the control of the rate of myogenic contractions of the larval hindgut.

show abstract

Peptide Cotransmitter at a Neuromuscular Junction

Cited by 211 publications

References 18 publications

Influences of glycine and neuron R14 on contraction of the anterior aorta of Aplysia.

Influences of glycine and neuron R14 on contraction of the anterior aorta of Aplysia.

Modulation of contractility and basic tonus in two serially homologous muscles in the cricket Teleogryllus oceanicus

Allatostatin‐like‐immunoreactive neurons of the tobacco hornworm, Manduca sexta , and isolation and identification of a new neuropeptide related to cockroach allatostatins

Contact Info

Product

Resources

About