Peptide-containing fractions in depression

Sælid, Gry Anette; Haug, J. O.; Heiberg, T.; Reichelt, Karl L.

doi:10.1016/0006-3223(85)90054-x

Cited by 17 publications

(4 citation statements)

References 27 publications

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“…In this respect, it is interesting to note that lower PEP activity has been found in depression (Maes et al a, 1995. Lower PEP activity in depression is in agreement (Abassi et al 1992 ;Watanabe et al 1993) with other findings that a low molecular weight hyperpeptiduria may occur in that illness (Saelid et al 1985). As described in the Introduction, there is also a significant magnitude of depressive symptoms in fibromyalgia patients and a strong co-morbidity between both disorders (Hudson et al 1992).…”

Section: Discussionsupporting

confidence: 78%

Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

Maes

Libbrecht²,

Hunsel³

et al. 1998

Psychol. Med.

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Section: Discussionsupporting

confidence: 78%

Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

Maes

Libbrecht²,

Hunsel³

et al. 1998

Psychol. Med.

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“…The disease takes time to develop, which probably points to unknown substances increasing and, or decreasing until they reach a critical level. We have previously found increased low molecular weight peptides (fragments of proteins) in urine from patients with depression [ 5 , 6 ] diagnosed according to The Diagnostic Manual of Mental Disorder, 3 rd edition (DSMIII). A peptide fraction was found that stimulated the uptake of serotonin (5-HT) into platelets [ 7 ] Compounds with opioid activity were also found.…”

Section: Introductionmentioning

confidence: 99%

Towards a possible aetiology for depressions?

Liu¹,

Heiberg

Reichelt³

2007

Behav Brain Funct

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“…Other results, however, do not corroborate the hypothesis of a general increase in peptidase enzyme activity in schizophrenia: (i) the postmortem brain and CSF concentrations of neuropeptides, which are known substrates of the above peptidases, were shown to be increased in schizophrenic patients, e.g. substance P and neurotensin (47); and (ii) low molecular weight peptiduria (23,29), and hyperpeptidemia (49) have been described in schizophrenia. Hyperpeptiduria and hyperpeptidemia may be related to decreased activity of peptide metabolizing enzymes (30,31 ).…”

Section: Discussionmentioning

confidence: 87%

“…Previously, we have also shown that lower enzyme activity of other peptidases, such as PEP (25,28) and angiotensin converting enzyme (ACE) (46) may occur in that illness. Lower peptidase activity in major depression ( 30,31 ) is further underscored by the findings of low molecular weight hyperpeptiduria ( 47). These findings strongly suggest that perturbations in peptidases may play a role in the pathophysiology of major depression.…”

Section: Discussionmentioning

confidence: 97%

Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: effects of antidepressants and antipsychotic drugs

Maes

Meester

Scharpé

et al. 1996

Acta Psychiatr Scand

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Maes M, De Meester I, Scharpé S, Desnyder R, Ranjan R, Meltzer HY. Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia effects of antidepressants and antipsychotic drugs. Acta Psychiatr Scand 1996: 93: 1–8. ©Munksgaard 1996. Recently, our laboratory reported that the activity of dipeptidyl‐peptidase IV (DPP IV) was significantly lower in the peripheral blood of major depressed patients than in normal controls. The present study examines plasma DPP IV activity in 43 major depressed and 13 schizophrenic subjects versus 21 normal controls and the effects of antidepressants and ntipsychotic drugs on plasma DPP IV activity. DPP IV activity was significantly lower in major depressed subjects than in normal controls and schizophrenic subjects. There was a trend towards higher DPP IV activity in schizophrenic patients than in normal controls. There were no significant effects of antidepressants or neuroleptics on plasma DPP IV activity in depressed and schizophrenic patients, respectively. There were no significant relationships between plasma DPP IV activity and plasma cortisol or immune‐inflammatory markers, such as serum interleukin‐6 (IL‐6) or soluble IL‐2 receptor. A significant and positive correlation was found between plasma DPP IV and prolyl endopeptidase (PEP) enzyme activity in the study group as a whole and in schizophrenic subjects. The results support the hypothesis that lower and higher plasma DPP IV activities are trait markers of major depression and schizophrenia, respectively. It is concluded that alterations in the enzyme activity of peptidases, such as DPP IV and PEP, play a role in the pathophysiology of major depression and schizophrenia.

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Peptide-containing fractions in depression

Cited by 17 publications

References 27 publications

Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

Towards a possible aetiology for depressions?

Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: effects of antidepressants and antipsychotic drugs

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