Peptide‐Based Molecular Hydrogels as Supramolecular Protein Mimics

Abstract

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Competition versus Cooperation in Catalytic Hydrogelators for anti‐Selective Mannich Reaction

“…A combination of co‐catalysts to work in concert, though highly difficult, can be used to perform asymmetric reactions with greater efficiency and selectivity than that usually possible with single catalytic systems. In this context, the use of different catalytic hydrogelators together can be very interesting to carry out enantioselective asymmetric reactions . In particular, when dealing with mutually incompatible groups, catalysis in solution can be challenging.…”

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

“…Self-assembly of low molecular weight gelators (LMWGs), on the other hand, has also attracted considerable attention in the past decade. 21 Various LMWGs, such as peptides, [22][23][24][25] carbohydrates 26 and synthetic organic compounds, 11 have been reported. Aromatic peptides are especially attractive due to their facile synthesis and strong p-p interactions in aqueous solution.…”

“…23,25 Different sequences of amino acids, used as hydrophilic head group, were optimized for various applications. 21,27,28 The Fmoc-protecting group is frequently applied as hydrophobic part since it is widely used in solid-phase peptide synthesis (SPPS). 21,22,29 Similar to polymeric hydrogels, the non-covalent interaction of peptide hydrogels also permits the development of multi-stimuli hydrogels.…”

“…21,27,28 The Fmoc-protecting group is frequently applied as hydrophobic part since it is widely used in solid-phase peptide synthesis (SPPS). 21,22,29 Similar to polymeric hydrogels, the non-covalent interaction of peptide hydrogels also permits the development of multi-stimuli hydrogels. Several stimuli, including chemical stimulus, 30,31 enzyme 32,33 and light, 34 were reported.…”

Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials

“…Hydrogelation can result from non-covalent selfassembly processes under appropriate conditions. 80 For example, for fibre-based hydrogels, self-assembly might occur involving the formation of nanofibers from β-sheet peptides. These fibres may then elongate in three dimensions, leading to increased fibre thickness and length, ultimately leading to fibrillar network formation.…”