Peptide-based gene delivery vectors

Kang, Ziyao; Meng, Qingbin; Liu, Keliang

doi:10.1039/c8tb03124j

Cited by 97 publications

(81 citation statements)

References 213 publications

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“…Similarly, the CPP RALA has been used to effectively deliver both eGFP and OVA mRNA and has been demonstrated to outperform the cationic lipid DOTAP and the fusogenic lipid DOPE [165]. However, current limitations include targeted cell delivery [164] and short circulation half-life due to the low stability in serum-containing medium [166].…”

Section: Peptide-based Vectorsmentioning

confidence: 99%

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

et al. 2020

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In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, therapeutic protein replacement therapies, and treatment of genetic diseases. However, challenges that impede the successful translation of these molecules into drugs are that (i) mRNA is a very large molecule, (ii) it is intrinsically unstable and prone to degradation by nucleases, and (iii) it activates the immune system. Although some of these challenges have been partially solved by means of chemical modification of the mRNA, intracellular delivery of mRNA still represents a major hurdle. The clinical translation of mRNA-based therapeutics requires delivery technologies that can ensure stabilization of mRNA under physiological conditions. Here, we (i) review opportunities and challenges in the delivery of mRNA-based therapeutics with a focus on non-viral delivery systems, (ii) present the clinical status of mRNA vaccines, and (iii) highlight perspectives on the future of this promising new type of medicine.

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Section: Peptide-based Vectorsmentioning

confidence: 99%

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

et al. 2020

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“…Peptides applied for non-viral gene delivery were summarized recently elsewhere. 297 When used as enhancers for viral gene delivery three different classes of peptides have been applied so far: cell penetrating peptides (CPP), fibrils formed from self-assembling peptides and proteins.…”

Section: Peptidesmentioning

confidence: 99%

Materials promoting viral gene delivery

Kaygisiz

Synatschke

2020

Biomater. Sci.

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“…Peptides offer a striking platform as non-viral gene delivery vectors which can minimize the disadvantages associated with viral vectors. Several groups have deliberated on nonviral gene delivery vehicles coupled with targeting peptides (Levine et al, 2013;Sharma et al, 2014;Kang et al, 2019;Wang et al, 2019). Though several functional peptide classes possess essential characteristics to overcome extracellular and intracellular barriers and make gene delivery feasible, still none of these functional peptides have been observed to contain all the essential characteristics required to overcome all of the barriers.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Gupta

Singh

Sharma

et al. 2020

Front. Bioeng. Biotechnol.

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The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are privileged to make the cutoff for sensing the cell-signal for biologics delivery and tissue engineering. The signature service and insoluble network formation of the peptide self-assemblies as hydrogels have drawn a spell of research activity among the scientists all around the globe in the past decades. The therapeutic peptide market players are anticipating promising growth opportunities due to the ample technological advancements in this field. The presence of the other organic moieties, enzyme substrates and well-established protecting groups like Fmoc and Boc etc., bring the best of both worlds. Since the large sequences of peptides severely limit the purification and their isolation, this article reviews the account of last 5 years' efforts on novel approaches for formulation and development of single molecule amino acids, ultra-short peptide self-assemblies (di-and tri-peptides only) and their derivatives as drug/gene carriers and tissue-engineering systems.

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Peptide-based gene delivery vectors

Abstract: Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery systems that encapsulate nucleic acids and deliver them to effective sites in the cell.

Cited by 97 publications

References 213 publications

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Materials promoting viral gene delivery

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

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