Peptide-Based Drugs and Drug Delivery Systems

Galdiero, Stefania; Gomes, Paula

doi:10.3390/molecules22122185

Cited by 18 publications

(14 citation statements)

References 31 publications

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“…The absorption of the SS-peptides does not affect the polarization of the mitochondrial membrane, which makes them ideal antioxidants for disease treatment [ 60 ]. For example, SS-02 was revealed to easily penetrate a single layer of intestinal epithelial cells from the basal and apical direction [ 61 ]. SS-02 has also been reported to penetrate the blood-brain barrier and thus serve as a neuroprotective agent [ 62 ].…”

Section: Peptide-based Mitochondrial Antioxidantsmentioning

confidence: 99%

Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment

Jiang

Yin

Chen

et al. 2020

Oxidative Medicine and Cellular Longevity

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Mitochondria are the main organelles that produce adenosine 5 ′ -triphosphate (ATP) and reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative damage. The irreversible oxidative damage in mitochondria has been implicated in various human diseases. Increasing evidence indicates the therapeutic potential of mitochondria-targeted antioxidants (MTAs) for oxidative damage-associated diseases. In this article, we introduce the advantageous properties of MTAs compared with the conventional (nontargeted) ones, review different mitochondria-targeted delivery systems and antioxidants, and summarize their experimental results for various disease treatments in different animal models and clinical trials. The combined evidence demonstrates that mitochondrial redox homeostasis is a potential target for disease treatment. Meanwhile, the limitations and prospects for exploiting MTAs are discussed, which might pave ways for further trial design and drug development.

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Section: Peptide-based Mitochondrial Antioxidantsmentioning

confidence: 99%

Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment

Jiang

Yin

Chen

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Different AMP-NP complexes have been tested throughout the years, trying to establish one with high activity toward the target pathogens, without having a significant toxicity for the other cells, a common flaw for AMPs and metal NPs (Galdiero and Gomes, 2017 ). Different metals were tested, as already described, such as iron oxide, coupled with LL-37, a natural host-defense peptide with antimicrobial activity (Niemirowicz et al, 2015 ).…”

Section: Nanoparticles In Therapeuticsmentioning

confidence: 99%

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

et al. 2018

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Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.

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“…Uncomplicated to design and synthesize, biocompatible, embedded with appropriate opportunities for chemical alterations, demonstrating molecular selectivity and specific interaction with diverse types of biological systems-all these characteristics make peptides ideal and flexible candidates for constructing tuneable nanostructures with normal end functionalization Yu et al, 2016;Galdiero and Gomes, 2017) (Figure 1). It is hypothesized that simple amino acids may be the first catalysts for formation of peptide bonds (Luisi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Gupta

Singh

Sharma

et al. 2020

Front. Bioeng. Biotechnol.

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The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are privileged to make the cutoff for sensing the cell-signal for biologics delivery and tissue engineering. The signature service and insoluble network formation of the peptide self-assemblies as hydrogels have drawn a spell of research activity among the scientists all around the globe in the past decades. The therapeutic peptide market players are anticipating promising growth opportunities due to the ample technological advancements in this field. The presence of the other organic moieties, enzyme substrates and well-established protecting groups like Fmoc and Boc etc., bring the best of both worlds. Since the large sequences of peptides severely limit the purification and their isolation, this article reviews the account of last 5 years' efforts on novel approaches for formulation and development of single molecule amino acids, ultra-short peptide self-assemblies (di-and tri-peptides only) and their derivatives as drug/gene carriers and tissue-engineering systems.

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Peptide-Based Drugs and Drug Delivery Systems

Abstract: n/a

Cited by 18 publications

References 31 publications

Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment

Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

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