Peptide and Protein Hormones

König, Wolfgang

doi:10.1002/14356007.a19_061

Cited by 5 publications

(3 citation statements)

References 1,626 publications

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“…[22] It might be argued that polyamines are in principle able to penetrate cell membranes [23] and that the triammonium salt likewise may cross the vesicle membrane. This property renders the system highly selective for a single appropriate external trigger molecule, and it should remain silent in the environment of a cell membrane.…”

Section: Methodsmentioning

confidence: 99%

Entirely Artificial Signal Transduction with a Primary Messenger

Bernitzki

Schräder

2009

Angewandte Chemie

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In einem künstlichen System gelingt die Botenstoff‐induzierte Signalleitung über eine Membran. Die Zugabe des primären Botenstoffs (DET; siehe Bild) führt zur Bildung eines heterodimeren Komplexes aus Transmembran‐Einheiten mit Tryptophan‐Donor (Trp) und Dansyl‐Akzeptor (Dan), der wiederum einen starken FRET‐Effekt auf der Innenseite der Membran induziert (FRET: resonanter Fluoreszenzenergietransfer).

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Section: Methodsmentioning

confidence: 99%

Entirely Artificial Signal Transduction with a Primary Messenger

Bernitzki

Schräder

2009

Angewandte Chemie

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“…Because derivatives of ethylene diamine do not occur in cells, this signaling system may be compatible with the chemical environment of living cells. Thus, a new feature has been introduced with the bisphosphonate head‐groups: provided that the whole amphiphilic transmembrane units can be embedded into cells, they could be selectively triggered by a non‐natural primary messenger without interfering with naturally existing signaling pathways 24…”

Section: Conceptmentioning

confidence: 99%

Lignin–polypropylene composites. II. Plasma modification of kraft lignin and particulate polypropylene

Toríz

Ramos

Young

2003

J of Applied Polymer Sci

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Indulin kraft lignin and polypropylene were subjected to plasma treatments in a rotating electrodeless plasma reactor at 13.56 MHz radio frequency, with the goal of improving the strength properties of the composites made from these materials. It was shown that efficient surface modification could be achieved by these plasma treatments, avoiding long reaction times and large volumes of reactants for modification by conventional wet chemistry. SiCl 4 -plasma treatments of lignin at 100 and 200 W resulted in silicon implantation in the range of 4 -10% that depended on the treatment time. However, the effect of power in the treatments was minimal, given that changes in silicon implantation were not observed for changes in this parameter. SiCl 4 -plasma treatment of polypropylene at 80 W, 1 and 10 min, resulted in silicon implantation in the order of 10 -15%, for the two different treatment times, showing that low power and short treatment times were sufficient to significantly alter the polypropylene surface. However at high power (250 W), the longer treatment time of polypropylene apparently led to formation of oligohalosilanes. Other plasma treatments in the rotating reactor such as plasmainduced copolymerization of acryloyl chloride on both lignin and polypropylene, and plasma-state polymerization of acryloyl chloride on polypropylene under pulsing conditions, resulted in thin film depositions. Evaluation of composites from these treated materials is described in the next contribution (Part III) from this series.

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“…More than 3000 analogs of LH-RH have been prepared in the last two decades as potential drugs for the following indications: inhibition of testosterone-and estrogen-dependent tumors (prostate and mammalian carcinoma), endometriosis, contraception, pubertas precox, uterine leiomyoma and in vivo or in vitro fertilization procedures (1)(2)(3)(4)(5). Both LH-RH antagonists and agonists lead to a drastic decline in gonadotropin release in animals and humans.…”

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confidence: 99%

S‐ and C‐glycopeptide derivatives of an LH‐RH agonist

Michael

Wittmann

König

et al. 1996

International Journal of Peptide and Protein Research

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The S-and C-glycosylated nonapeptides 1 and 2 were synthesized as analogs of the non-glycosylated LH-RH agonist buserelin (pGlu-His-Trp-Ser-Tyr-D-Ser( tBu)-Leu-Arg-Pro-NHEt) by segment condensation in solution. 1 and 2 differ from this peptide in the amino acid in position 6. In the first case ( l ) , Dserine (tBu) is substituted by D-CySteine carrying a rhamnosyl residue, in the second case (2) D-alanine carrying a galactosyl moiety bound as C-glycoside is incorporated. The bioactivity of both glycopeptides as fertility drugs was determined from the dose dependent LH release in male rats. Additionally, in female rats the ovulation rate was assessed. As a result the analog 1 exhibits a similar biological activity as buserelin while analog 2 shows about 25% of this potency. Compared to buserelin the solubility of the analogs 1 and 2 in aqueous buffer is improved by more than two orders of magnitude due to the carbohydrate moieties. 0 Munksgaard 1996.The native human luteinizing hormone-releasing hormone ( LH-RH; pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-

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Peptide and Protein Hormones

Cited by 5 publications

References 1,626 publications

Entirely Artificial Signal Transduction with a Primary Messenger

Entirely Artificial Signal Transduction with a Primary Messenger

Lignin–polypropylene composites. II. Plasma modification of kraft lignin and particulate polypropylene

S‐ and C‐glycopeptide derivatives of an LH‐RH agonist

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