Peptide and Amide Bond Containing Dendrimers

Crespo, Laia; Sanclimens, Glòria; Pons, Miquel; Giralt, Ernest; Royo, Míriam; Alberício, Fernando

doi:10.1002/chin.200536230

Cited by 16 publications

(21 citation statements)

References 1 publication

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“…Amino acid based dendrimers can be described as molecules based on branched amino acids (i.e., lysine, glutamic acid, aspartic acid, cis-4-amino-L-proline [207][208][209][210][211][212]) or other building blocks, such as cyclic peptides, poly(amido amines) (PAMAM) [213], polypropylene imines (PPI) [214], poly(aryl ethers) [215,216] and a large variety of other branched moieties including carbohydrates [217,218]. In this review, we will focus on examples coming from amino acid based dendrimers exclusively composed of amide bonds.…”

Section: Dendrimersmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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Abstract:Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics has helped to establish these polypeptide-based constructs as polymeric nanomedicines for different applications, such as disease treatment and diagnostics. Herein, we provide an overview of the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research towards clinical applications.

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Section: Dendrimersmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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“…59 Recently, Wei et al 60 reported various inorganic nanoparticles such as terbium, erbium, yttrium, zinc, gadolinium, and others, using a facile homogeneous precipitation method, and the authors found that these particles show low toxicity even at a concentration of 5 mg/mL. 60 Dendrimers are synthesized by two commonly used approaches (ie, convergent and divergent 61 ), as described in Figure 4.…”

Section: Preparation Methodsmentioning

confidence: 99%

“…Apart from this, cyclic peptides have great potential to be therapeutic agents against many debilitating amyloid-related diseases. One example of this type of peptide was reported by Todorova et al; 32 this peptide, cyc (60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70), is derived from human apolipoprotein CII, which acts against amyloid formation by the fibrillogenic peptide, apoC-II (60-70). Liu et al 33 explored a B6 peptide in conjugation with polyethylene glycol-polylactic acid nanoparticles to enhance the delivery of neuroprotective drugs across the blood-brain barrier for the treatment of Alzheimer's disease.…”

Section: Peptide Nanoparticles and Their Conjugatesmentioning

confidence: 99%

Nanoparticles in relation to peptide and protein aggregation

Zaman

Ahmad

Qadeer

et al. 2014

IJN

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Over the past two decades, there has been considerable research interest in the use of nanoparticles in the study of protein and peptide aggregation, and of amyloid-related diseases. The influence of nanoparticles on amyloid formation yields great interest due to its small size and high surface area-to-volume ratio. Targeting nucleation kinetics by nanoparticles is one of the most searched for ways to control or induce this phenomenon. The observed effect of nanoparticles on the nucleation phase is determined by particle composition, as well as the amount and nature of the particle’s surface. Various thermodynamic parameters influence the interaction of proteins and nanoparticles in the solution, and regulate the protein assembly into fibrils, as well as the disaggregation of preformed fibrils. Metals, organic particles, inorganic particles, amino acids, peptides, proteins, and so on are more suitable candidates for nanoparticle formulation. In the present review, we attempt to explore the effects of nanoparticles on protein and peptide fibrillation processes from both perspectives (ie, as inducers and inhibitors on nucleation kinetics and in the disaggregation of preformed fibrils). Their formulation and characterization by different techniques have been also addressed, along with their toxicological effects, both in vivo and in vitro.

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“…To improve the affinity of the peptide for the HA of IFV, a dimer of the sialic acid-mimic peptide with a branched lysine (Lys) core [(Ala-Arg-Leu-Pro-Arg) 2 Lys-Lys(N 3 )] was chemically synthesized (SI Methods and Fig. S2A) (20,21). This peptide dimer had an azide Lys with an azido side chain (N 3 ) at the carboxyl terminal of the Lys core.…”

Section: Significancementioning

confidence: 99%

Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide

Matsubara

Ujie

Yamamoto

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The progression of influenza varies according to age and the presence of an underlying disease; appropriate treatment is therefore required to prevent severe disease. Anti-influenza therapy, such as with neuraminidase inhibitors, is effective, but diagnosis at an early phase of infection before viral propagation is critical. Here, we show that several dozen plaque-forming units (pfu) of influenza virus (IFV) can be detected using a boron-doped diamond (BDD) electrode terminated with a sialic acid-mimic peptide. The peptide was used instead of the sialyloligosaccharide receptor, which is the common receptor of influenza A and B viruses required during the early phase of infection, to capture IFV particles. The peptide, which was previously identified by phage-display technology, was immobilized by click chemistry on the BDD electrode, which has excellent electrochemical characteristics such as low background current and weak adsorption of biomolecules. Electrochemical impedance spectroscopy revealed that H1N1 and H3N2 IFVs were detectable in the range of 20-500 pfu by using the peptide-terminated BDD electrode. Our results demonstrate that the BDD device integrated with the receptor-mimic peptide has high sensitivity for detection of a low number of virus particles in the early phase of infection.influenza virus | boron-doped diamond electrode | sialic acid-mimic peptide | electrochemical impedance spectroscopy | click chemistry

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Peptide and Amide Bond Containing Dendrimers

Cited by 16 publications

References 1 publication

Peptide-Based Polymer Therapeutics

Peptide-Based Polymer Therapeutics

Nanoparticles in relation to peptide and protein aggregation

Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide

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