Peptide alkaloids from Ziziphus spinachristi

Tschesche, Rudolf; Khokhar, Ibatsam; Spilles, Christian; Radloff, Michael

doi:10.1016/0031-9422(74)80352-3

Cited by 18 publications

(6 citation statements)

References 5 publications

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“…Several studies have indicated that Z. spina-christi leaves contain flavonoids, tannins, sterols, saponins and triterpenoids. Furthermore, 11 different cyclopeptide alkaloids exist in Z. spina-christi stem and root [20][21][22][23]. In Khuzestan, a southern province of Iran, Z. spina-christi leaves have been widely used as natural detergent and shampoo due to their saponin content [24].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the saponin green extraction from Ziziphus spina-christi leaves using hydrothermal, microwave and Bain-Marie water bath heating methods

Mohaddes-Kamranshahi

Jafarizadeh‐Malmiri

Simjoo

et al. 2019

Green Processing and Synthesis

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Saponin as a biosurfactant was extracted from Iranian Ziziphus spina-christi leaves using three green extraction methods namely, autoclave, microwave and Bain-Marie heating methods. In this study, three solvents namely, methanol, ethanol and water were used to extract saponin. The results revealed that water, as compared to the methanol and ethanol, is a more suitable solvent to extract saponin from the Z. spina-christi leaves. The obtained results indicated that saponin extraction using autoclave provided more suitable physico-chemical properties along with a better yield. In fact, maximum foam volume (12.56 cm3), color intensity (3.24% absorbance unit [a.u.]) and turbidity (1.39% a.u.) of the extracted solutions was obtained by the autoclave heating method. The high performance liquid chromatography (HPLC) results also illustrated that the amounts of extracted saponin using autoclave, Bain-Marie and microwave heating extraction methods were 14, 8.8 and 1.3 (intensity mV), respectively. The results obtained by HPLC were reconfirmed by Fourier transform infrared (FT-IR) analysis.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the saponin green extraction from Ziziphus spina-christi leaves using hydrothermal, microwave and Bain-Marie water bath heating methods

Mohaddes-Kamranshahi

Jafarizadeh‐Malmiri

Simjoo

et al. 2019

Green Processing and Synthesis

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“…Bark infusions are known to treat coughs ( [5]; [35][36][37]; [14,18]). The active ingredients are several alkaloids known as peptide alkaloids such as mucronine D [34].…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro cytotoxic, anti-inflammatory and anti-microbiological activities of two indigenous Venda medicinal plants

et al. 2016

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Background: The Vhembe region of the Limpopo province has a rich tradition of medicinal plants use. Traditionally, boiled roots of Ziziphus mucronata are used in the treatment of boils, general swelling and other skin infections. A combination of leaf paste and root infusion treats measles, dysentery, chest complains, and gland swelling. Pterocarpus angolensis is famous for the treatment of menorrhagia, infertility in women, wounds and pain management. The purpose of the present study was to compare the cytotoxicity, anti-inflammatory potential and anti-microbial activities of Ziziphus mucronata and Pterocarpus angolensis from the Vhembe region. Method: U937, MeWo, Vero and RAW 264.7 cells were treated to various concentrations (50, 100, or 125 or 250 μg/ml depending on assays) of Ziziphus mucronata and Pterocarpus angolensis. Cytotoxicity assay was done using MTT; Antiinflammatory activity was assessed using NO production; Anti-bacterial activity was done using the Micro-Broth dilution method and Anti-mycobacteria activity was determined using the Alamar Blue Method while RT activity was measured by ELISA. Results: Cytotoxicity results showed that Pterocarpus was more toxic than Ziziphus as observed in the Vero and MeWo cells; however both displayed toxicity towards a Human cancer cell line. Both extracts did not inhibit nitrate production but induced significant increase in macrophage activation. The plant extracts have shown anti-tuberculosis activity at concentrations >500 μg/ml and there was moderation inhibition of HIV replication. Conclusions: The results obtained indicated that the extracts have pro-inflammatory properties, and the observed toxicity on malignant cell lines must be investigated further for promising anti-cancer drug therapy.

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“…Previous studies indicated that Z. spina-christi contained flavonoids, tannins, sterols, saponins, and triterpenoids (Shahat et al, 2001;Farmani et al, 2016). In addition, eleven different cyclopeptide alkaloids were reported from its stem bark and/or root bark (Tschesche et al, 1974;Shah et al, 1986;Abdel-galil et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-(HRMS)-SPE-NMR

et al. 2017

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Seven cyclopeptide alkaloids were isolated from the stem bark of Ziziphus nummularia and Ziziphus spina-christi. Three previously undescribed compounds were identified: nummularine-U, spinanine-B and spinanine-C, together with the known compounds mauritine-F, nummularine-D, nummularine-E and amphibine-D. For their purification either semi-preparative HPLC with DAD and ESIMS detection or HPLC-PDA-(HRMS)-SPE-NMR was applied, together with conventional separation methods. Their structures were elucidated by spectroscopic means.

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Peptide alkaloids from Ziziphus spinachristi

Cited by 18 publications

References 5 publications

Evaluation of the saponin green extraction from Ziziphus spina-christi leaves using hydrothermal, microwave and Bain-Marie water bath heating methods

Evaluation of the saponin green extraction from Ziziphus spina-christi leaves using hydrothermal, microwave and Bain-Marie water bath heating methods

Comparative in vitro cytotoxic, anti-inflammatory and anti-microbiological activities of two indigenous Venda medicinal plants

Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-(HRMS)-SPE-NMR

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