Peptic Ulceration

DeBakey, Michael E.

doi:10.1001/archsurg.1937.01190080031002

Cited by 11 publications

(2 citation statements)

References 41 publications

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“…More than half of their patients were >70 years of age, with a mortality rate of 61% [9]. Age appears to have a major influence on the outcome, as reported by other series with mortality rates of 18%-48% in elderly patients [10][11][12][13][14]. Coutsofields reported 33% mortality in patients >60 years of age compared to 5% mortality for those <60 years of age 7.…”

Section: Discussionmentioning

confidence: 98%

Mortality in Perforated Peptic Ulcer Patients After Selective Management of Stratified Poor Risk Cases

Rahman

Islam

Flora³

et al. 2007

World j. surg.

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Section: Discussionmentioning

confidence: 98%

Mortality in Perforated Peptic Ulcer Patients After Selective Management of Stratified Poor Risk Cases

Rahman

Islam

Flora³

et al. 2007

World j. surg.

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“…The Mann-Williamson preparation diverts both bile and pancreatic juice and produces duodenal ulcers. DeBakey [22] used an operation designed by Eisels-berg and studied the relative importance of diverting pancreatic juice and bile in the augmentation of ulcer formation in dogs. Ulcers develop in 50% of the control animals.…”

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confidence: 99%

Graded gastric bypass

Mason

Ito

1978

World j. surg.

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Gastric bypass is an extensive exclusion operation which was developed in 1966 and has been used in over 600 patients for the treatment of morbid obesity. Stomal ulceration has developed in 2% of patients and has usually occurred because the stomach was transected at too low a level. To determine the effect of varying levels of transection and exclusion of the stomach, graded gastric bypass was studied in 2 peptic ulcer models in dogs. With histamine-in-beeswax, stomal ulcers occurred whenever there was more than 63% of the stomach located above the gastroenterostomy. With common duct ligation, stomal ulcers were not observed in dogs with 44% or less of the stomach excluded, but when more than 44% of the stomach emptied through the duodenum, duodenal ulcers developed. Stomal ulceration occurred as a result of excessive acid production from large fundic segments stimulated by histamine. Duodenal ulcers resulted from a deficiency in buffering of acid when sufficient stomach was excluded and when an adequate volume of acid entered the duodenum where bile was excluded. These experiments add further emphasis to the importance of high transection of the stomach in gastric bypass, but also suggest that the occurrence of common duct obstruction will introduce the risk of duodenal ulcer in patients who have had gastric bypass for the treatment of obesity.

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Gastroenterology

Jones¹

1938

Arch Intern Med (Chic)

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Peptic Ulceration

Cited by 11 publications

References 41 publications

Mortality in Perforated Peptic Ulcer Patients After Selective Management of Stratified Poor Risk Cases

Mortality in Perforated Peptic Ulcer Patients After Selective Management of Stratified Poor Risk Cases

Graded gastric bypass

Gastroenterology

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